10 results on '"Ajai K Malhotra"'
Search Results
2. Contribution by Dr Timothy C Fabian: liver trauma
- Author
-
Ajai K Malhotra
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2023
- Full Text
- View/download PDF
3. Delay in ICU transfer is protective against ICU readmission in trauma patients: a naturally controlled experiment
- Author
-
Ajai K Malhotra, Stephen E Ranney, Stas Amato, Peter Callas, Lloyd Patashnick, Tim H Lee, and Gary C An
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Background Unplanned intensive care unit (ICU) readmission—ICU bounce back (ICUbb)—is associated with worse outcomes. Patients not requiring organ system support or intensive nursing are deemed ‘ICU discharge ready’ and transfer orders are placed. However, actual transfer only occurs when an appropriate, non-ICU bed is available. This is dependent on inherent system inefficiencies resulting in a naturally controlled experiment between when patients actually transfer: Early (24 hours) transfers, after order placement. This study leverages that natural experiment to determine if additional ICU time is protective against ICUbb. We hypothesize that Delayed transfer is protective against ICUbb.Methods Using a retrospective, cohort design, we queried a trauma research repository and electronic medical record during a 10-year period to capture traumatized patients admitted to the ICU. Patients were categorized into Early (24 hours) groups based on actual transfer time after order placement. Patient characteristics (age, Charlson Comorbidity Index (CCI)) and Injury Severity Score (ISS) were analyzed. Univariate and multivariate analyses were performed to compare ICUbb rates among Early and Unintended-Delayed groups.Results Of the 2004 patients who met the criteria, 1690 fell into the Early group, and 314 fell into the Delayed. The Early group was younger (mean age 52±23 vs. 55±22 years), had fewer comorbidities (median CCI score 1 (0, 3) vs. 2 (1, 3)), and was less injured (median ISS 17 (10–22) vs. 17 (13–25)), all p
- Published
- 2021
- Full Text
- View/download PDF
4. Alternative clinical trial designs
- Author
-
John A Harvin, Raminder Nirula, Ben L Zarzaur, Benjamin T King, and Ajai K Malhotra
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
High-quality clinical trials are needed to advance the care of injured patients. Traditional randomized clinical trials in trauma have challenges in generating new knowledge due to many issues, including logistical difficulties performing individual randomization, unclear pretrial estimates of treatment effect leading to often unpowered studies, and difficulty assessing the generalizability of an intervention given the heterogeneity of both patients and trauma centers. In this review, we discuss alternative clinical trial designs that can address some of these difficulties. These include pragmatic trials, cluster randomization, cluster randomized stepped wedge designs, factorial trials, and adaptive designs. Additionally, we discuss how Bayesian methods of inference may provide more knowledge to trauma and acute care surgeons compared with traditional, frequentist methods.
- Published
- 2020
- Full Text
- View/download PDF
5. Patient-centered outcomes research and the injured patient: a summary of application
- Author
-
Deborah M Stein, Elliott R Haut, Mitchell J Cohen, Laura N Godat, Jason W Smith, Michelle A Price, Bellal Joseph, Raminder Nirula, Rochelle A Dicker, Todd W Costantini, Avery B Nathens, Eileen Bulger, Ben L Zarzaur, Ajai K Malhotra, Saman Arbabi, Aaron R Jensen, Marie M Crandall, and Rosemary A Kozar
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
As trauma surgeons, we focus on the immediate care and needs of the injured patient every day. Historically, trauma and injury research has focused on outcomes such as mortality, complications, and length of stay; and process metrics such as time to CT scan, resuscitation checklist frequencies, or venous thromboembolism prophylaxis rates. These outcomes are perceived by healthcare providers to be important, but patients likely have different perceptions of what outcomes are most important to measure and improve. True patient-centered outcomes research involves the healthcare providers, and the entire team of stakeholders including patients and the community. Understanding the process of stakeholder engagement and the barriers trauma researchers must overcome to effectively enter this field of research is important. This summary aims to inform the trauma research community on the basics of patient-centered outcomes research, priorities for funding from the Patient-Centered Outcomes Research Institute, resources for collaboration around patient-centered outcomes research, and a unique career development and training opportunity for early career trauma surgeons to develop a skill set in patient-centered outcomes research.
- Published
- 2020
- Full Text
- View/download PDF
6. Dissemination, implementation, and de-implementation: the trauma perspective
- Author
-
Deborah M Stein, Elliott R Haut, Mitchell J Cohen, Jason W Smith, Michelle A Price, Bellal Joseph, Raminder Nirula, Rochelle A Dicker, Todd W Costantini, Avery B Nathens, Eileen Bulger, Ben L Zarzaur, Ajai K Malhotra, Saman Arbabi, Marie M Crandall, Rosemary A Kozar, and Vanessa P Ho
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2020
- Full Text
- View/download PDF
7. Factors associated with receipt of intracranial pressure monitoring in older adults with traumatic brain injury
- Author
-
Deborah M Stein, Julie A Dunn, Thomas J Schroeppel, Jeanette Podbielski, Bellal Joseph, Jason Murry, Christopher P Michetti, Karen Brasel, Krista Kaups, Karen Lewandowski, Kaushik Mukherjee, Fady S Nasrallah, Kathryn B Schaffer, Paola Pieri, James Haan, Kelly Lightwine, Rachele Solomon, Robert D Winfield, Ajai K. Malhotra, Charles Adams, D'Andrea Joseph, Miklosh Bala, Rosemary Kozar, Tim Lee, Stephanie Lueckel, Zara Cooper, Alok Gupta, Jennifer Albrecht, Niels D. Martin, Patrizio Petrone, Jonathan Gates, Mira Ghneim, Ariel Knight, Anna Liveris, Jill Watras, Scott Armen, J Christopher Zacko, Brittany Smoot, Zachery Stillman, Cindy Hsu, Umer F. Bhatti, Matthew E Lissauer, Marc LaFonte, Kaveh Najafi, Kristelle J. Imperio-Lagabon, Kathleen Hirsch, Cherisse Berry, Derek Freitas, Daniel Cullinane, Roshini Ramawani, Michael Truitt, Chris Pearcy, Habiba Hashimi, Jeffry Claridge, Husayn Ladhani, Jennifer L. Hartwell, Jessica Ballou, Martin Croce, Stephanie Markle, Sally Osserwaarde, Joseph Posluszny, Benjamin Stocker, Tjasa Hranjec, Lucy Martinek, Daniel J. Grabo, Uzer Khan, Danielle Tatum, Tomas Jacome, Alisha Jawani, Allison E. Berndtson, Terry G. Curry, Linda A. Dultz, Natasha N. Houshmand, Martin D Zielinski, Joy D. Hughes, Jennifer Hartwell, Gary T. Marshall, Matthew M. Carrick, Abhijit Pathak, Andrea Van Zandt, Nina Glass, David Livingston, Shea Gregg, Travis Webb, Byron Drumheller, and Robert Barraco
- Subjects
medicine.medical_specialty ,RD1-811 ,Traumatic brain injury ,Population ,intracranial pressure ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,traumatic ,0302 clinical medicine ,brain injuries ,medicine ,education ,Intraparenchymal hemorrhage ,Original Research ,Intracranial pressure ,Geriatrics ,education.field_of_study ,geriatrics ,business.industry ,RC86-88.9 ,Glasgow Coma Scale ,030208 emergency & critical care medicine ,Medical emergencies. Critical care. Intensive care. First aid ,medicine.disease ,Intraventricular hemorrhage ,Emergency medicine ,Intracranial pressure monitoring ,Surgery ,business ,030217 neurology & neurosurgery - Abstract
BackgroundThe Brain Trauma Foundation (BTF) Guidelines for the Management of Severe Traumatic Brain Injury (TBI) include intracranial pressure monitoring (ICPM), yet very little is known about ICPM in older adults. Our objectives were to characterize the utilization of ICPM in older adults and identify factors associated with ICPM in those who met the BTF guidelines.MethodsWe analyzed data from the American Association for the Surgery of Trauma Geriatric TBI Study, a registry study conducted among individuals with isolated, CT-confirmed TBI across 45 trauma centers. The analysis was restricted to those aged ≥60. Independent factors associated with ICPM for those who did and did not meet the BTF guidelines were identified using logistic regression.ResultsOur sample was composed of 2303 patients, of whom 66 (2.9%) underwent ICPM. Relative to Glasgow Coma Scale (GCS) score of 13 to 15, GCS score of 9 to 12 (OR 10.2; 95% CI 4.3 to 24.4) and GCS score of DiscussionWorsening GCS, intraparenchymal/intraventricular hemorrhage, and skull fractures were associated with ICPM among older adults with TBI, yet utilization of ICPM remains low, especially among those meeting the BTF guidelines, and potential benefits remain unclear. This study highlights the need for better understanding of factors that influence compliance with BTF guidelines and the risks versus benefits of ICPM in this population.Level of evidencePrognostic and epidemiological, level III.
- Published
- 2021
8. Delay in ICU transfer is protective against ICU readmission in trauma patients: a naturally controlled experiment
- Author
-
Stephen E Ranney, Lloyd Patashnick, Ajai K Malhotra, Stas Amato, Gary An, Peter W. Callas, and Tim H Lee
- Subjects
medicine.medical_specialty ,Multivariate analysis ,RD1-811 ,intensive care units ,Patient characteristics ,Critical Care and Intensive Care Medicine ,law.invention ,quality improvement ,patient readmission ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,law ,Transfer (computing) ,Medicine ,Controlled experiment ,Original Research ,business.industry ,RC86-88.9 ,030208 emergency & critical care medicine ,Medical emergencies. Critical care. Intensive care. First aid ,Evidence-based medicine ,Intensive care unit ,Emergency medicine ,Injury Severity Score ,Surgery ,business ,multiple trauma ,Cohort study - Abstract
BackgroundUnplanned intensive care unit (ICU) readmission—ICU bounce back (ICUbb)—is associated with worse outcomes. Patients not requiring organ system support or intensive nursing are deemed ‘ICU discharge ready’ and transfer orders are placed. However, actual transfer only occurs when an appropriate, non-ICU bed is available. This is dependent on inherent system inefficiencies resulting in a naturally controlled experiment between when patients actually transfer: Early (24 hours) transfers, after order placement. This study leverages that natural experiment to determine if additional ICU time is protective against ICUbb. We hypothesize that Delayed transfer is protective against ICUbb.MethodsUsing a retrospective, cohort design, we queried a trauma research repository and electronic medical record during a 10-year period to capture traumatized patients admitted to the ICU. Patients were categorized into Early (24 hours) groups based on actual transfer time after order placement. Patient characteristics (age, Charlson Comorbidity Index (CCI)) and Injury Severity Score (ISS) were analyzed. Univariate and multivariate analyses were performed to compare ICUbb rates among Early and Unintended-Delayed groups.ResultsOf the 2004 patients who met the criteria, 1690 fell into the Early group, and 314 fell into the Delayed. The Early group was younger (mean age 52±23 vs. 55±22 years), had fewer comorbidities (median CCI score 1 (0, 3) vs. 2 (1, 3)), and was less injured (median ISS 17 (10–22) vs. 17 (13–25)), all pDiscussionDespite higher age, CCI score, and ISS, the Unintended-Delayed group experienced fewer ICUbb. After controlling for age, CCI and ISS, Delayed transfer reduced ICUbb risk by 78%. Specific care elements affording this protection remain to be elucidated.Level of evidenceLevel III.Study typeTherapeutic study.
- Published
- 2021
9. Patient-centered outcomes research and the injured patient: a summary of application
- Author
-
Elliott R Haut, Mitchell J Cohen, Laura N Godat, Jason W Smith, Bellal Joseph, Raminder Nirula, Rochelle A Dicker, Avery B Nathens, Eileen Bulger, Ben L Zarzaur, Ajai K Malhotra, Saman Arbabi, Aaron R Jensen, Marie M Crandall, and Rosemary A Kozar
- Subjects
Resuscitation ,medicine.medical_specialty ,business.industry ,Patient-centered outcomes ,lcsh:Surgery ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,MEDLINE ,Stakeholder engagement ,lcsh:RD1-811 ,lcsh:RC86-88.9 ,Review ,Critical Care and Intensive Care Medicine ,Checklist ,Nursing ,medicine ,Surgery ,Outcomes research ,business ,Venous thromboembolism ,Career development - Abstract
As trauma surgeons, we focus on the immediate care and needs of the injured patient every day. Historically, trauma and injury research has focused on outcomes such as mortality, complications, and length of stay; and process metrics such as time to CT scan, resuscitation checklist frequencies, or venous thromboembolism prophylaxis rates. These outcomes are perceived by healthcare providers to be important, but patients likely have different perceptions of what outcomes are most important to measure and improve. True patient-centered outcomes research involves the healthcare providers, and the entire team of stakeholders including patients and the community. Understanding the process of stakeholder engagement and the barriers trauma researchers must overcome to effectively enter this field of research is important. This summary aims to inform the trauma research community on the basics of patient-centered outcomes research, priorities for funding from the Patient-Centered Outcomes Research Institute, resources for collaboration around patient-centered outcomes research, and a unique career development and training opportunity for early career trauma surgeons to develop a skill set in patient-centered outcomes research.
- Published
- 2020
10. Building the future for national trauma research
- Author
-
Gregory J Jurkovich, Eileen M Bulger, Michelle A Price, Bellal Joseph, Raminder Nirula, Elliott R. Haut, Eileen Bulger, Rosemary A Kozar, Saman Arbabi, Mitchell J. Cohen, Todd W. Costantini, Marie M. Crandall, Rochelle A. Dicker, Rosemary A. Kozar, Ajai K. Malhotra, Avery B. Nathens, Michelle A. Price, Jason W. Smith, Deborah M. Stein, and Ben L. Zarzaur
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
This paper describes the current funding, infrastructure growth and future state of trauma research. It also introduces a group of review articles generated from The Future of Trauma Research: Innovations in Research Methodology conference hosted by the American College of Surgeons Committee on Trauma in July 2019.
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.