1. A genetic linkage study of a kindred with X-linked retinitis pigmentosa
- Author
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P S Harper, G W Hoare, A F Wright, Marcelle Jay, J F Clayton, A L Lyness, and Shomi S. Bhattacharya
- Subjects
Adult ,Male ,X Chromosome ,Adolescent ,Genetic Linkage ,Genetic counseling ,DNA, Recombinant ,law.invention ,Cellular and Molecular Neuroscience ,law ,Genetic linkage ,Retinitis pigmentosa ,medicine ,Electroretinography ,Humans ,Fluorescein Angiography ,Child ,X chromosome ,Sex Chromosome Aberrations ,Genetics ,Linkage (software) ,business.industry ,Genetic Carrier Screening ,medicine.disease ,Sensory Systems ,eye diseases ,Pedigree ,Ophthalmology ,Child, Preschool ,Recombinant DNA ,Female ,X-linked retinitis pigmentosa ,Restriction fragment length polymorphism ,business ,Retinitis Pigmentosa ,Research Article - Abstract
8 páginas, 4 figuras, 2 tablas.-- Licence Creative Commons, attribution, Non-commercial licence.-- et al., A large kindred with X-linked retinitis pigmentosa (XLRP) was investigated clinically and by means of genetic linkage with a view to developing methods of carrier detection and early diagnosis. A restriction fragment length polymorphism, identified by recombinant DNA probe L1.28, showed close genetic linkage to XLRP in this kindred and is a potentially useful marker for the purposes of genetic counselling., This study was also supported by: MRC Grant G80/09861/N; a grant from the British Retinitis Pigmentosa Society, and a grant from the National Retinitis Pigmentosa Foundation, Inc.
- Published
- 1985