2,984 results
Search Results
52. Workarounds to hospital electronic prescribing systems: a qualitative study in English hospitals.
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Cresswell, Kathrin M., Mozaffar, Hajar, Lee, Lisa, Williams, Robin, and Sheikh, Aziz
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HOSPITALS ,INFORMATION storage & retrieval systems ,MEDICAL databases ,INTERVIEWING ,RESEARCH methodology ,PATIENT safety ,RESEARCH funding ,QUALITATIVE research ,THEMATIC analysis ,DATA analysis software ,ELECTRONIC health records - Abstract
Background Concerns with the usability of electronic prescribing (ePrescribing) systems can lead to the development of workarounds by users. Objectives To investigate the types of workarounds users employed, the underlying reasons offered and implications for care provision and patient safety. Methods We collected a large qualitative data set, comprising interviews, observations and project documents, as part of an evaluation of ePrescribing systems in five English hospitals, which we conceptualised as case studies. Data were collected at up to three different time points throughout implementation and adoption. Thematic analysis involving deductive and inductive approaches was facilitated by NVivo 10. Results Our data set consisted of 173 interviews, 24 rounds of observation and 17 documents. Participating hospitals were at various stages of implementing a range of systems with differing functionalities. We identified two types of workarounds: informal and formal. The former were informal practices employed by users not approved by management, which were introduced because of perceived changes to professional roles, issues with system usability and performance and challenges relating to the inaccessibility of hardware. The latter were formalised practices that were promoted by management and occurred when systems posed threats to patient safety and organisational functioning. Both types of workarounds involved using paper and other software systems as intermediaries, which often created new risks relating to a lack of efficient transfer of real-time information between different users. Conclusions Assessing formal and informal workarounds employed by users should be part of routine organisational implementation strategies of major health information new risks and present new opportunities for improvement in system design and integration. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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53. Cigarette prices and smoking among adults in eight sub-Saharan African countries: evidence from the Global Adult Tobacco Survey.
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Filby, Samantha
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RESEARCH funding ,SMOKING ,STATISTICAL sampling ,DESCRIPTIVE statistics ,WORLD health ,SURVEYS ,TOBACCO products ,DATA analysis software ,CONFIDENCE intervals - Published
- 2024
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54. In vitro flow diversion effect of the ReSolv stent with the shelf technique in a bifurcation aneurysm model.
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Belanger, Brooke L., Morrish, Rosalie, McClarty, Davis, Barnstable, Colette, Muir, Warren, Ghazizadeh, Soheil, Eesa, Muneer, Fiorella, David, Wong, John H., Sadasivan, Chandar, and Mitha, Alim P.
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INTRACRANIAL aneurysm surgery ,IN vitro studies ,RESEARCH funding ,DATA analysis ,T-test (Statistics) ,KRUSKAL-Wallis Test ,SURGICAL stents ,TREATMENT effectiveness ,ANGIOGRAPHY ,DESCRIPTIVE statistics ,ANALYSIS of variance ,STATISTICS - Abstract
Background Flow-diverting stents are not currently indicated for the treatment of bifurcation aneurysms, and some case series have demonstrated low occlusion rates, possibly due to a lack in neck coverage. The ReSolv stent is a unique hybrid metal/polymer stent that can be deployed with the shelf technique in order to improve neck coverage. Methods A Pipeline, unshelfed ReSolv, and shelfed ReSolv stent were deployed in the left-sided branch of an idealized bifurcation aneurysm model. After determining stent porosity, high-speed digital subtraction angiography runs were acquired under pulsatile flow conditions. Time--density curves were created using two region of interest (ROI) paradigms (total aneurysm and left/right), and four parameters were extracted to characterize flow diversion performance. Results The shelfed ReSolv stent demonstrated better aneurysm outflow alterations compared to the Pipeline and unshelfed ReSolv stent when using the total aneurysm as the ROI. On the left side of the aneurysm, there was no significant difference between the shelfed ReSolv stent and the Pipeline. On the right side of the aneurysm, however, the shelfed ReSolv stent had a significantly better contrast washout profile than the unshelfed ReSolv stent and the Pipeline stent. Conclusions The ReSolv stent with the shelf technique demonstrates the potential to improve flow diversion outcomes for bifurcation aneurysms. Further in vivo testing will help to determine whether the additional neck coverage leads to better neointimal scaffolding and long-term aneurysm occlusion. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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55. Cigarette excise tax structure and cigarette prices in nine sub-Saharan African countries: evidence from the Global Adult Tobacco Survey.
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Filby, Samantha, Van Walbeek, Corné, and Pan, Liping
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TAXATION economics ,COMMERCIAL statistics ,RESEARCH funding ,T-test (Statistics) ,GOVERNMENT policy ,TOBACCO ,DESCRIPTIVE statistics ,TOBACCO products - Published
- 2024
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56. Economic evaluations of fall prevention exercise programs: a systematic review.
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Pinheiro, Marina B., Sherrington, Catherine, Howard, Kirsten, Caldwell, Patrick, Tiedemann, Anne, Wang, Belinda, Oliveira, Juliana S., Santos, Andreia, Bull, Fiona C., Willumsen, Juana F., Michaleff, Zoe A., Ferguson, Sarah, Mayo, Eleesheva, Fairhall, Nicola J., Bauman, Adrian E., Norris, Sarah, and S Oliveira, Juliana
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ACCIDENTAL fall prevention ,PREVENTION ,ELDER care ,DATABASE searching ,NURSING home residents ,ADULT care facilities ,QUALITY-adjusted life years ,EXERCISE ,RESEARCH funding ,EXERCISE therapy ,COST benefit analysis ,SYSTEMATIC reviews - Abstract
Objective: To investigate cost-effectiveness and costs of fall prevention exercise programmes for older adults.Design: Systematic review.Data Sources: Medline, Embase, Web of Science, Scopus, National Institute for Health Research Economic Evaluation Database, Health Technology Assessment database, Tufts Cost-Effectiveness Analysis Registry, Research Papers in Economics and EconLit (inception to May 2022).Eligibility Criteria For Study Selection: Economic evaluations (trial-based or model-based) and costing studies investigating fall prevention exercise programmes versus no intervention or usual care for older adults living in the community or care facilities, and reporting incremental cost-effectiveness ratio (ICER) for fall-related outcomes or quality-adjusted life years (QALY, expressed as cost/QALY) and/or intervention costs.Results: 31 studies were included. For community-dwelling older adults (21 economic evaluations, 6 costing studies), results ranged from more effective and less costly (dominant) interventions up to an ICER of US$279 802/QALY gained and US$11 986/fall prevented (US$ in 2020). Assuming an arbitrary willingness-to-pay threshold (US$100 000/QALY), most results (17/24) were considered cost-effective (moderate certainty). The greatest value for money (lower ICER/QALY gained and fall prevented) appeared to accrue for older adults and those with high fall risk, but unsupervised exercise appeared to offer poor value for money (higher ICER/QALY). For care facilities (two economic evaluations, two costing studies), ICERs ranged from dominant (low certainty) to US$35/fall prevented (moderate certainty). Overall, intervention costs varied and were poorly reported.Conclusions: Most economic evaluations investigated fall prevention exercise programmes for older adults living in the community. There is moderate certainty evidence that fall prevention exercise programmes are likely to be cost-effective. The evidence for older adults living in care facilities is more limited but promising.Prospero Registration Number: PROSPERO 2020 CRD42020178023. [ABSTRACT FROM AUTHOR]- Published
- 2022
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57. Three methods of delivering clinic-based training on syndromic management of sexually transmitted diseases in South Africa: a pilot study.
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Weaver, Marcia R., Pillay, Erushka, Jed, Suzanne L., de Kadt, Julia, Galagan, Sean, Gilvydis, Jennifer, Marumo, Eva, Mawandia, Shreshth, Naidoo, Evasen, Owens, Tamara, Prongay, Vickery, and O'Malley, Gabrielle
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SEXUALLY transmitted diseases ,COMMUNICABLE diseases ,SEXUAL health ,DISEASE management ,ANTI-infective agents ,DIAGNOSIS of HIV infections ,THERAPEUTICS ,HIV infections ,MEDICAL education ,SEXUALLY transmitted disease diagnosis ,PREVENTION of sexually transmitted diseases ,SEXUALLY transmitted disease treatment ,CLINICS ,COMPARATIVE studies ,CONDOMS ,EMPLOYEE orientation ,GENITALIA ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,MEDICAL prescriptions ,PHYSICAL diagnosis ,PRIMARY health care ,QUALITY assurance ,RESEARCH ,RESEARCH funding ,STATISTICAL sampling ,SIMULATED patients ,SYNDROMES ,PILOT projects ,EVALUATION research ,RANDOMIZED controlled trials ,CONTACT tracing ,EVALUATION of human services programs ,ODDS ratio - Abstract
Introduction: The South African National Department of Health sought to improve syndromic management of sexually transmitted infections (STIs). Continuing medical education on STIs was delivered at primary healthcare (PHC) clinics using one of three training methods: (1) lecture, (2) computer and (3) paper-based. Clinics with training were compared with control clinics.Methods: Ten PHC clinics were randomly assigned to control and 10 to each training method arm. Clinicians participated in on-site training on six modules; two per week for three weeks. Each clinic was visited by three or four unannounced standardised patient (SP) actors pre-training and post-training. Male SPs reported symptoms of male urethritis syndrome and female SPs reported symptoms of vaginal discharge syndrome. Quality of healthcare was measured by whether or not clinicians completed five tasks: HIV test, genital exam, correct medications, condoms and partner notification.Results: An average of 31% of clinicians from each PHC attended each module. Quality of STI care was low. Pre-training (n=128) clinicians completed an average of 1.63 tasks. Post-training (n=114) they completed 1.73. There was no change in the number of STI tasks completed in the control arm and an 11% increase overall in the training arms relative to the control (ratio of relative risk (RRR)=1.11, 95% CI 0.67 to 1.84). Across training arms, there was a 26% increase (RRR=1.26, 95% CI 0.77 to 2.06) associated with lecture, 17% increase (RRR=1.17, 95% CI 0.59 to 2.28) with paper-based and 13% decrease (RRR=0.87, 95% CI 0.40 to 1.90) with computer arm relative to the control.Conclusions: Future interventions should address increasing training attendance and computer-based training effectiveness.Trial Registration Number: AEARCTR-0000668. [ABSTRACT FROM AUTHOR]- Published
- 2016
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58. Standards for UNiversal reporting of patient Decision Aid Evaluation studies: the development of SUNDAE Checklist.
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Sepucha, Karen R., Abhyankar, Purva, Hoffman, Aubri S., Bekker, Hilary L., LeBlanc, Annie, Levin, Garrie A., Ropka, Mary, Shaffer, Victoria A., Sheridan, Stacey L., Stacey, Dawn, Stalmeier, Peep, Ha Vo, Wills, Gelia E., and Thomson, Richard
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DECISION making ,CONSENSUS (Social sciences) ,DELPHI method ,EXPERIMENTAL design ,INFORMATION storage & retrieval systems ,MEDICAL databases ,INTERPROFESSIONAL relations ,MANUSCRIPTS ,RESEARCH methodology ,MEDICAL protocols ,QUALITY assurance ,RESEARCH funding ,ELECTRONIC publications ,EVALUATION research ,HUMAN services programs ,PATIENT decision making - Abstract
Background Patient decision aids (PDAs) are evidence-based tools designed to help patients make specific and deliberated choices among healthcare options. The International Patient Decision Aid Standards (IPDAS) Collaboration review papers and Cochrane systematic review of PDAs have found significant gaps in the reporting of evaluations of PDAs, including poor or limited reporting of PDA content, development methods and delivery. This study sought to develop and reach consensus on reporting guidelines to improve the quality of publications evaluating PDAs. Methods An international workgroup, consisting of members from IPDAS Collaboration, followed established methods to develop reporting guidelines for PDA evaluation studies. This paper describes the results from three completed phases: (1) planning, (2) drafting and (3) consensus, which included a modified, two-stage, online international Delphi process. The work was conducted over 2 years with bimonthly conference calls and three inperson meetings. The workgroup used input from these phases to produce a final set of recommended items in the form of a checklist. Results The SUNDAE Checklist (Standards for UNiversal reporting of patient Decision Aid Evaluations) includes 26 items recommended for studies reporting evaluations of PDAs. In the two-stage Delphi process, 117/143 (82%) experts from 14 countries completed round 1 and 96/1 17 (82%) completed round 2. Respondents reached a high level of consensus on the importance of the items and indicated strong willingness to use the items when reporting PDA studies. Conclusion The SUNDAE Checklist will help ensure that reports of PDA evaluation studies are understandable, transparent and of high quality. A separate Explanation and Elaboration publication provides additional details to support use of the checklist. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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59. Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants.
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Beardsall, Kathryn, Thomson, Lynn, Elleri, Daniela, Dunger, David B., and Hovorka, Roman
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PREMATURE infants ,GLUCOSE ,INSULIN ,BIRTH weight ,NEONATAL intensive care ,PATIENT monitoring equipment ,RESEARCH ,TIME ,RESEARCH methodology ,VERY low birth weight ,HYPOGLYCEMIC agents ,GESTATIONAL age ,BLOOD sugar ,NEONATAL intensive care units ,EVALUATION research ,MEDICAL cooperation ,PATIENT monitoring ,COMPARATIVE studies ,RANDOMIZED controlled trials ,INSULIN pumps ,RESEARCH funding - Abstract
Objective: Closed-loop systems have been used to optimise insulin delivery in children with diabetes, but they have not been tested in neonatal intensive care. Extremely preterm infants are prone to hyperglycaemia and hypoglycaemia; both of which have been associated with adverse outcomes. Insulin sensitivity is notoriously variable in these babies and glucose control is time-consuming, with management requiring frequent changes of dextrose-containing fluids and careful monitoring of insulin treatment. We aimed to evaluate the feasibility of closed-loop management of glucose control in these infants.Design and Setting: Single-centre feasibility study with a randomised parallel design in a neonatal intensive care unit. Eligibility criteria included birth weight <1200 g and <48 hours of age. All infants had subcutaneous continuous glucose monitoring for the first week of life, with those in the intervention group receiving closed-loop insulin delivery in a prespecified window, between 48 and 72 hours of age during which time the primary outcome was percentage of time in target (sensor glucose 4-8 mmol/L).Results: The mean (SD) gestational age and birth weight of intervention and control study arms were 27.0 (2.4) weeks, 962 (164) g and 27.5 (2.8) weeks, 823 (282) g, respectively, and were not significantly different. The time in target was dramatically increased from median (IQR) 26% (6-64) with paper guidance to 91% (78-99) during closed loop (p<0.001). There were no serious adverse events and no difference in total insulin infused.Conclusions: Closed-loop glucose control based on subcutaneous glucose measurements appears feasible as a potential method of optimising glucose control in extremely preterm infants. [ABSTRACT FROM AUTHOR]- Published
- 2020
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60. No smoking gun: tobacco taxation and smuggling in Sierra Leone.
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Gallien, Max and Occhiali, Giovanni
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DRUG laws ,CRIME prevention ,TAXATION ,EVALUATION of medical care ,MIDDLE-income countries ,GOVERNMENT policy ,LOW-income countries ,RESEARCH funding ,TOBACCO products ,TOBACCO - Published
- 2023
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61. Patterns of anxiety and distress over 12 months following participation in HPV primary screening.
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Marlow, Laura A. V., McBride, Emily, Ridout, Deborah, Forster, Alice S., Kitchener, Henry, and Waller, Jo
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PAPILLOMAVIRUSES ,RESEARCH ,VERTEBRATES ,RESEARCH methodology ,MEDICAL screening ,EARLY detection of cancer ,PAP test ,EVALUATION research ,COMPARATIVE studies ,VIRUS diseases ,PAPILLOMAVIRUS diseases ,QUESTIONNAIRES ,RESEARCH funding ,CERVIX uteri tumors ,ANXIETY - Abstract
Objectives: Many countries are now using primary human papillomavirus (HPV) testing for cervical screening, testing for high-risk HPV and using cytology as triage. An HPV-positive result can have an adverse psychological impact, at least in the short term. In this paper, we explore the psychological impact of primary HPV screening over 12 months.Methods: Women were surveyed soon after receiving their results (n=1133) and 6 (n=762) and 12 months (n=537) later. Primary outcomes were anxiety (Short-Form State Anxiety Inventory-6) and distress (General Health Questionnaire-12). Secondary outcomes included concern, worry about cervical cancer and reassurance. Mixed-effects regression models were used to explore differences at each time point and change over time across four groups according to their baseline result: control (HPV negative/HPV cleared/normal cytology and not tested for HPV); HPV positive with normal cytology; HPV positive with abnormal cytology; and HPV persistent (ie, second consecutive HPV-positive result).Results: Women who were HPV positive with abnormal cytology had the highest anxiety scores at baseline (mean=42.2, SD: 15.0), but this had declined by 12 months (mean=37.0, SD: 11.7) and was closer to being within the 'normal' range (scores between 34 and 36 are considered 'normal'). This group also had the highest distress at baseline (mean=3.3, SD: 3.8, scores of 3+ indicate case-level distress), but the lowest distress at 12 months (mean=1.9, SD: 3.1). At 6 and 12 months, there were no between-group differences in anxiety or distress for any HPV-positive result group when compared with the control group. The control group were less concerned and more reassured about their result at 6 and 12 months than the HPV-positive with normal cytology group.Conclusions: Our findings suggest the initial adverse impact of an HPV-positive screening result on anxiety and distress diminishes over time. Specific concerns about the result may be longer lasting and efforts should be made to address them. [ABSTRACT FROM AUTHOR]- Published
- 2022
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62. Effects of stick design features on perceptions of characteristics of cigarettes.
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Borland, Ron and Savvas, Steven
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MARKETING ,ANALYSIS of variance ,ATTITUDE (Psychology) ,PACKAGING ,SENSORY perception ,QUESTIONNAIRES ,RESEARCH funding ,SEX distribution ,STATISTICS ,TOBACCO ,DATA analysis ,REPEATED measures design ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Objective To examine the extent (if any) that cigarette stick dimension, tipping paper design and other decorative design/branding have on Australian smokers' perceptions of those cigarettes. Methods An internet survey of 160 young Australian adult ever-smokers who were shown computer images of three sets of cigarette sticksdfive sticks of different lengths and diameters (set A), five sticks with different tipping paper design (set B) and four sticks of different decorative design (set C). Branding was a between-subjects randomised condition for set C. For each set, respondents ranked sticks on most and least attractive, highest and lowest quality and strongest and weakest taste. Results Cigarette sticks were perceived as different on attractiveness, quality and strength of taste. Standard stick length/diameter was perceived as the most attractive and highest quality stick, with men more inclined to rate a slim stick as less attractive. A stick with a cork-patterned tipping paper and a gold band was seen as most attractive, of highest quality and strongest in taste compared to other tipping designs. Branded sticks were seen as more attractive, higher in quality and stronger tasting than non-branded designs, regardless of brand, although the effects were stronger for a prestige compared with a budget brand. Conclusions Characteristics of the cigarette stick affect smokers' perceptions of the attributes of those cigarettes and thus are a potential means by which product differentiation can occur. A comprehensive policy to eliminate promotional aspects of cigarette design and packaging needs to include rules about stick design. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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63. Scaling early child development: what are the barriers and enablers?
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Cavallera, Vanessa, Tomlinson, Mark, Radner, James, Coetzee, Bronwynè, Daelmans, Bernadette, Hughes, Rob, Pérez-Escamilla, Rafael, Silver, Karlee L., and Dua, Tarun
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CHILD development ,SEMI-structured interviews ,MIDDLE-income countries ,SNOWBALL sampling ,LITERATURE reviews ,HEALTH policy ,RESEARCH ,EVALUATION of human services programs ,LEADERSHIP ,RESEARCH methodology ,EVALUATION research ,MEDICAL cooperation ,HUMAN services programs ,COMPARATIVE studies ,CHILD health services ,RESEARCH funding ,DEVELOPING countries - Abstract
The Sustainable Development Goals, Global Strategy for Women's, Children's and Adolescents' Health (2016-2030) and Nurturing Care Framework all include targets to ensure children thrive However, many projects to support early childhood development (ECD) do not 'scale well' and leave large numbers of children unreached. This paper is the fifth in a series examining effective scaling of ECD programmes. This qualitative study explored experiences of scaling-up among purposively recruited implementers of ECD projects in low- and middle-income countries. Participants were sampled, by means of snowball sampling, from existing networks notably through Saving Brains®, Grand Challenges Canada®. Findings of a recent literature review on scaling-up frameworks, by the WHO, informed the development of a semistructured interview schedule. All interviews were conducted in English, via Skype, audio recorded and transcribed verbatim. Interviews were analysed using framework analysis. Framework analysis identified six major themes based on a standard programme cycle: planning and strategic choices, project design, human resources, financing and resource mobilisation, monitoring and evaluation, and leadership and partnerships. Key informants also identified an overarching theme regarding what scaling-up means. Stakeholders have not found existing literature and available frameworks helpful in guiding them to successful scale-up. Our research suggests that rather than proposing yet more theoretical guidelines or frameworks, it would be better to support stakeholders in developing organisational leadership capacity and partnership strategies to enable them to effectively apply a practical programme cycle or systematic process in their own contexts. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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64. Estimating the percentage of European MSM eligible for PrEP: insights from a bio-behavioural survey in thirteen cities.
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Cordioli, Maddalena, Gios, Lorenzo, Huber, Jörg W., Sherriff, Nigel, Folch, Cinta, Alexiev, Ivailo, Dias, Sónia, Nöstlinger, Christiana, Gama, Ana, Naseva, Emilia, Staneková, Danica Valkovičová, Marcus, Ulrich, Schink, Susanne Barbara, Rosinska, Magdalena, Blondeel, Karel, Toskin, Igor, Mirandola, Massimo, and Valkovičová Staneková, Danica
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HIV infection epidemiology ,HIV prevention ,ANTI-HIV agents ,RESEARCH ,HUMAN sexuality ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,PATIENTS' attitudes ,HOMOSEXUALITY ,PREVENTIVE health services ,COMPARATIVE studies ,RESEARCH funding ,METROPOLITAN areas - Abstract
Objectives: This paper aims to estimate the percentage of European men who have sex with men (MSM) who may benefit from pre-exposure prophylaxis (PrEP), applying the three most widely used HIV risk indices for MSM (MSM Risk Index, Menza score, San Diego Early Test (SDET) score) and drawing on a large-scale multisite bio-behavioural survey (Sialon II).Methods: The Sialon II study was a bio-behavioural survey among MSM implemented in 13 European cities using either time-location sampling or respondent-driven sampling. Biological and behavioural data from 4901 MSM were collected. Only behavioural data of HIV-negative individuals were considered. Three widely used risk indices to assess HIV acquisition risk among MSM were used to estimate individual HIV risk scores and PrEP eligibility criteria.Results: 4219 HIV-negative MSM were considered. Regardless the HIV risk score used and the city, percentages of MSM eligible for PrEP were found to range between 5.19% and 73.84%. Overall, the MSM Risk Index and the Menza score yielded broadly similar percentages, whereas the SDET Index provided estimates constantly lower across all cities. Although all the three scores correlated positively (r>0.6), their concordance was highly variable (0.01Conclusion: Our findings showed the impact of different scoring systems on the estimation of the percentage of MSM who may benefit from PrEP in European cities. Although our primary aim was not to compare the performance of different HIV risk scores, data show that a considerable percentage of MSM in each city should be offered PrEP in order to reduce HIV infections. As PrEP is highly effective at preventing HIV among MSM, our findings provide useful, practical guidance for stakeholders in implementing PrEP at city level to tackle HIV infections in Europe. [ABSTRACT FROM AUTHOR] - Published
- 2021
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65. Unpacking commercial sector opposition to European smoke-free policy: lack of unity, 'fear of association' and harm reduction debates.
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Weishaar, Heide, Amos, Amanda, and Collin, Jeff
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SMOKING prevention ,CONTENT analysis ,INDUSTRIES ,INTERVIEWING ,RESEARCH methodology ,RESEARCH funding ,TOBACCO ,QUALITATIVE research ,GOVERNMENT policy ,JUDGMENT sampling ,INSTITUTIONAL cooperation ,DATA analysis software - Abstract
Objective Tobacco companies have made extensive efforts to build alliances against comprehensive smoke-free legislation. This article analyses the interaction between actors who opposed the development of the European Council Recommendation on smoke-free environments. Methods Drawing on data from 200 policy documents and 32 semistructured interviews and using qualitative textual analysis and organisational network analysis, opponents' positions on, and responses to, the policy initiative, strategies to oppose the policy, and efforts to build alliances were investigated. Results The non-binding nature of the policy, scientific evidence and clear political will to adopt EU-wide measures combined to limit the intensity of commercial sector opposition to the comprehensive EU smoke-free policy. Most tobacco companies, led by the Confederation of European Community Cigarette Manufacturers (CECCM), voiced reservations against the proposal, criticised the policy process and fought flanking measures on product regulation. However, some companies focused on instigating harm reduction debates. These divergent approaches and the reluctance of other commercial actors to demonstrate solidarity with the tobacco sector prevented the establishment of a cohesive commercial sector alliance. Conclusions The comparatively limited opposition to EU smoke-free policy contrasts with previous accounts of tobacco industry resistance to tobacco control. While context-specific factors can partially explain these differences, the paper indicates that the sector's diminished credibility and lack of unity hampered political engagement and alliance building. Industry efforts to emphasise the benefits of smokeless tobacco during smoke-free policy debates highlight the potential of harm reduction as a gateway for tobacco companies to re-enter the political arena. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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66. Harm is all you need? Best interests and disputes about parental decision-making.
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Birchley, Giles
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DECISION making ,PARENTING ,BIOETHICS ,BIOETHICISTS ,THERAPEUTICS ,HUMAN rights ,CHILDREN'S rights ,CONCEPTS ,CONFLICT (Psychology) ,INFORMED consent (Medical law) ,LIFE expectancy ,MINORS ,PSYCHOLOGY of parents ,RESEARCH funding ,VALUE (Economics) ,SOCIAL responsibility ,PSYCHOLOGY - Abstract
A growing number of bioethics papers endorse the harm threshold when judging whether to override parental decisions. Among other claims, these papers argue that the harm threshold is easily understood by lay and professional audiences and correctly conforms to societal expectations of parents in regard to their children. English law contains a harm threshold which mediates the use of the best interests test in cases where a child may be removed from her parents. Using Diekema's seminal paper as an example, this paper explores the proposed workings of the harm threshold. I use examples from the practical use of the harm threshold in English law to argue that the harm threshold is an inadequate answer to the indeterminacy of the best interests test. I detail two criticisms: First, the harm standard has evaluative overtones and judges are loath to employ it where parental behaviour is misguided but they wish to treat parents sympathetically. Thus, by focusing only on 'substandard' parenting, harm is problematic where the parental attempts to benefit their child are misguided or wrong, such as in disputes about withdrawal of medical treatment. Second, when harm is used in genuine dilemmas, court judgments offer different answers to similar cases. This level of indeterminacy suggests that, in practice, the operation of the harm threshold would be indistinguishable from best interests. Since indeterminacy appears to be the greatest problem in elucidating what is best, bioethicists should concentrate on discovering the values that inform best interests. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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67. Standardising the measurement of e-cigarette taxes in the USA, 2010-2020.
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Cotti, Chad, Nesson, Erik, Pesko, Michael F., Phillips, Serena, and Tefft, Nathan
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TAXATION standards ,TAXATION ,ELECTRONIC cigarettes ,RESEARCH funding - Published
- 2023
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68. A comparison of alternative methods for measuring cigarette prices.
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Chaloupka, Frank J., Tauras, John A., Strasser, Julia H., Willis, Gordon, Gibson, James T., and Hartman, Anne M.
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SMOKING ,TOBACCO products ,QUESTIONNAIRES ,RESEARCH funding ,SALES personnel ,TAXATION ,COST analysis ,DESCRIPTIVE statistics ,ECONOMICS - Abstract
Background Government agencies, public health organisations and tobacco control researchers rely on accurate estimates of cigarette prices for a variety of purposes. Since the 1950s, the Tax Burden on Tobacco (TBOT) has served as the most widely used source of this price data despite its limitations. Purpose This paper compares the prices and collection methods of the TBOT retail-based data and the 2003 and 2006/2007 waves of the population-based Tobacco Use Supplement to the Current Population Survey (TUS-CPS). Methods From the TUS-CPS, we constructed multiple state-level measures of cigarette prices, including weighted average prices per pack (based on average prices for single-pack purchases and average prices for carton purchases) and compared these with the weighted average price data reported in the TBOT. We also constructed several measures of tax avoidance from the TUS-CPS self-reported data. Results For the 2003 wave, the average TUS-CPS price was 71 cents per pack less than the average TBOT price; for the 2006/2007 wave, the difference was 47 cents. TUS-CPS and TBOT prices were also significantly different at the state level. However, these differences varied widely by state due to tax avoidance opportunities, such as cross-border purchasing. Conclusions The TUS-CPS can be used to construct valid measures of cigarette prices. Unlike the TBOT, the TUS-CPS captures the effect of price-reducing marketing strategies, as well as tax avoidance practices and non-traditional types of purchasing. Thus, self-reported data like TUS-CPS appear to have advantages over TBOT in estimating the 'real' price that smokers face. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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69. Clinical interventions to reduce secondhand smoke exposure among pregnant women: a systematic review.
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Van T. Tong, Dietz, Patricia M., Rolle, Italia V., Kennedy, Sara M., Thomas, William, and England, Lucinda J.
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PASSIVE smoking ,CINAHL database ,CONFIDENCE intervals ,COUNSELING ,INFORMATION storage & retrieval systems ,MEDICAL databases ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,HEALTH outcome assessment ,PATIENT education ,PRENATAL care ,RESEARCH funding ,SYSTEMATIC reviews ,RESEARCH bias ,DESCRIPTIVE statistics ,ODDS ratio ,PREGNANCY ,PREVENTION - Abstract
Objective To conduct a systematic review of clinical interventions to reduce secondhand smoke (SHS) exposure among non-smoking pregnant women. Data sources We searched 16 databases for publications from 1990 to January 2013, with no language restrictions. Study selection Papers were included if they met the following criteria: (1) the study population included non-smoking pregnant women exposed to SHS, (2) the clinical interventions were intended to reduce SHS exposure at home, (3) the study included a control group and (4) outcomes included either reduced SHS exposure of non-smoking pregnant women at home or quit rates among smoking partners during the pregnancy of the woman. Data extraction Two coders independently reviewed each abstract or full text to identify eligible papers. Two abstractors independently coded papers based on US Preventive Services Task Force criteria for study quality (good, fair, poor), and studies without biochemically-verified outcome measures were considered poor quality. Data synthesis From 4670 papers, we identified five studies that met our inclusion criteria: four focused on reducing SHS exposure among non-smoking pregnant women, and one focused on providing cessation support for smoking partners of pregnant women. All were randomised controlled trials, and all reported positive findings. Three studies were judged poor quality because outcome measures were not biochemically-verified, and two were considered fair quality. Conclusions Clinical interventions delivered in prenatal care settings appear to reduce SHS exposure, but study weaknesses limit our ability to draw firm conclusions. More rigorous studies, using biochemical validation, are needed to identify strategies for reducing SHS exposure in pregnant women. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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70. At-risk children with asthma (ARC): a systematic review.
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Buelo, Audrey, McLean, Susannah, Julious, Steven, Flores-Kim, Javier, Bush, Andy, Henderson, John, Paton, James Y., Sheikh, Aziz, Shields, Michael, Pinnock, Hilary, and ARC Group
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ASTHMA risk factors ,ASTHMATICS ,DISEASES ,ASTHMA in children ,META-analysis ,ASTHMA treatment ,ASTHMA diagnosis ,ASTHMA ,RESEARCH funding ,SYSTEMATIC reviews - Abstract
Introduction: Asthma attacks are responsible for considerable morbidity and may be fatal. We aimed to identify and weight risk factors for asthma attacks in children (5-12 years) in order to inform and prioritise care.Methods: We systematically searched six databases (May 2016; updated with forward citations January 2017) with no language/date restrictions. Two reviewers independently selected studies for inclusion, assessed study quality and extracted data. Heterogeneity precluded meta-analysis. Weighting was undertaken by an Expert Panel who independently assessed each variable for degree of risk and confidence in the assessment (based on study quality and size, effect sizes, biological plausibility and consistency of results) and then achieved consensus by discussion. Assessments were finally presented, discussed and agreed at a multidisciplinary workshop.Results: From 16 109 records, we included 68 papers (28 cohort; 4 case-control; 36 cross-sectional studies). Previous asthma attacks were associated with greatly increased risk of attack (ORs between 2.0 and 4.1). Persistent symptoms (ORs between 1.4 and 7.8) and poor access to care (ORs between 1.2 and 2.3) were associated with moderately/greatly increased risk. A moderately increased risk was associated with suboptimal drug regimen, comorbid atopic/allergic disease, African-American ethnicity (USA), poverty and vitamin D deficiency. Environmental tobacco smoke exposure, younger age, obesity and low parental education were associated with slightly increased risk.Discussion: Assessment of the clinical and demographic features identified in this review may help clinicians to focus risk reduction management on the high-risk child. Population level factors may be used by health service planners and policymakers to target healthcare initiatives.Trial Registration Number: CRD42016037464. [ABSTRACT FROM AUTHOR]- Published
- 2018
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71. Consensus-based recommendations for the use of biosimilars to treat rheumatological diseases.
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Kay, Jonathan, Schoels, Monika M., Dörner, Thomas, Emery, Paul, Kvien, Tore K., Smolen, Josef S., Breedveld, Ferdinand C., and Task Force on the Use of Biosimilars to Treat Rheumatological Diseases
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BIOTHERAPY ,DRUG therapy for rheumatism ,BIOLOGICAL products ,COMPARATIVE studies ,CONSENSUS (Social sciences) ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,RESEARCH ,RESEARCH funding ,SYSTEMATIC reviews ,EVIDENCE-based medicine ,EVALUATION research - Abstract
The study aimed to develop evidence-based recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases. The task force comprised an expert group of specialists in rheumatology, dermatology and gastroenterology, and pharmacologists, patients and a regulator from ten countries. Four key topics regarding biosimilars were identified through a process of discussion and consensus. Using a Delphi process, specific questions were then formulated to guide a systematic literature review. Relevant English-language publications through November 2016 were searched systematically for each topic using Medline; selected papers and pertinent reviews were examined for additional relevant references; and abstracts presented at the 2015 and 2016 American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) annual scientific meetings were searched for those about biosimilars. The experts used evidence obtained from these studies to develop a set of overarching principles and consensus recommendations. The level of evidence and grade of recommendation were determined for each. By the search strategy, 490 references were identified. Of these, 29 full-text papers were included in the systematic review. Additionally, 20 abstracts were retrieved from the ACR and EULAR conference abstract databases. Five overarching principles and eight consensus recommendations were generated, encompassing considerations regarding clinical trials, immunogenicity, extrapolation of indications, switching between bio-originators and biosimilars and among biosimilars, and cost. The level of evidence and grade of recommendation for each varied according to available published evidence. Five overarching principles and eight consensus recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases were developed using research-based evidence and expert opinion. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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72. Recommendations for determining the validity of consumer wearable heart rate devices: expert statement and checklist of the INTERLIVE Network.
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Mühlen, Jan M., Stang, Julie, Skovgaard, Esben Lykke, Judice, Pedro B., Molina-Garcia, Pablo, Johnston, William, Sardinha, Luís B., Ortega, Francisco B., Caulfield, Brian, Bloch, Wilhelm, Cheng, Sulin, Ekelund, Ulf, Brønd, Jan Christian, Grøntved, Anders, Schumann, Moritz, and Lykke Skovgaard, Esben
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PHOTOPLETHYSMOGRAPHY ,HEART beat ,AEROBIC capacity ,SCIENTIFIC literature ,EXERCISE physiology ,SPORTS sciences ,RESEARCH evaluation ,PSYCHOMETRICS ,QUALITY of life ,QUESTIONNAIRES ,RESEARCH funding ,BREAST tumors - Abstract
Assessing vital signs such as heart rate (HR) by wearable devices in a lifestyle-related environment provides widespread opportunities for public health related research and applications. Commonly, consumer wearable devices assessing HR are based on photoplethysmography (PPG), where HR is determined by absorption and reflection of emitted light by the blood. However, methodological differences and shortcomings in the validation process hamper the comparability of the validity of various wearable devices assessing HR. Towards Intelligent Health and Well-Being: Network of Physical Activity Assessment (INTERLIVE) is a joint European initiative of six universities and one industrial partner. The consortium was founded in 2019 and strives towards developing best-practice recommendations for evaluating the validity of consumer wearables and smartphones. This expert statement presents a best-practice validation protocol for consumer wearables assessing HR by PPG. The recommendations were developed through the following multi-stage process: (1) a systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, (2) an unstructured review of the wider literature pertaining to factors that may introduce bias during the validation of these devices and (3) evidence-informed expert opinions of the INTERLIVE Network. A total of 44 articles were deemed eligible and retrieved through our systematic literature review. Based on these studies, a wider literature review and our evidence-informed expert opinions, we propose a validation framework with standardised recommendations using six domains: considerations for the target population, criterion measure, index measure, testing conditions, data processing and the statistical analysis. As such, this paper presents recommendations to standardise the validity testing and reporting of PPG-based HR wearables used by consumers. Moreover, checklists are provided to guide the validation protocol development and reporting. This will ensure that manufacturers, consumers, healthcare providers and researchers use wearables safely and to its full potential. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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73. The new role of diagnostic angiography in coronary physiological assessment.
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Ghobrial, Mina, Haley, Hazel Arfah, Gosling, Rebecca, Rammohan, Vignesh, Lawford, Patricia V., Hose, D. Rod, Gunn, Julian P., and Morris, Paul D.
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CORONARY angiography ,TRANSLUMINAL angioplasty ,MAGNETIC resonance angiography ,MYOCARDIAL infarction ,CHEST pain ,CORONARY circulation ,CARDIAC magnetic resonance imaging ,CORONARY artery bypass ,CORONARY disease ,RESEARCH funding - Abstract
The role of 'stand-alone' coronary angiography (CAG) in the management of patients with chronic coronary syndromes is the subject of debate, with arguments for its replacement with CT angiography on the one hand and its confinement to the interventional cardiac catheter laboratory on the other. Nevertheless, it remains the standard of care in most centres. Recently, computational methods have been developed in which the laws of fluid dynamics can be applied to angiographic images to yield 'virtual' (computed) measures of blood flow, such as fractional flow reserve. Together with the CAG itself, this technology can provide an 'all-in-one' anatomical and functional investigation, which is particularly useful in the case of borderline lesions. It can add to the diagnostic value of CAG by providing increased precision and reduce the need for further non-invasive and functional tests of ischaemia, at minimal cost. In this paper, we place this technology in context, with emphasis on its potential to become established in the diagnostic workup of patients with suspected coronary artery disease, particularly in the non-interventional setting. We discuss the derivation and reliability of angiographically derived fractional flow reserve (CAG-FFR) as well as its limitations and how CAG-FFR could be integrated within existing national guidance. The assessment of coronary physiology may no longer be the preserve of the interventional cardiologist. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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74. Variations in cigarette brand characteristics: can consumers tell the difference?
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Pennings, Jeroen L. A., Ferris Wayne, Geoffrey, Klerx, Walther N. M., Pauwels, Charlotte G. G. M., and Talhout, Reinskje
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CARBON monoxide ,NICOTINE ,SENSORY perception ,CONSUMER attitudes ,COMMERCIAL product evaluation ,FACTOR analysis ,RESEARCH funding ,TOBACCO products ,SMOKING ,NEW product development - Published
- 2023
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75. Interventions employed to improve intrahospital handover: a systematic review.
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Robertson, Eleanor R., Morgan, Lauren, Bird, Sarah, Catchpole, Ken, and McCulloch, Peter
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ADVERSE health care events ,CINAHL database ,DATABASE evaluation ,EXPERIMENTAL design ,HOSPITAL care ,MEDICAL information storage & retrieval systems ,MEDLINE ,QUALITY assurance ,RESEARCH funding ,TERMS & phrases ,SYSTEMATIC reviews ,EVIDENCE-based medicine ,PROFESSIONAL practice ,PREVENTION - Abstract
Background Modern medical care requires numerous patient handovers/handoffs. Handover error is recognised as a potential hazard in patient care, and the information error rate has been estimated at 13%. While accurate, reliable handover is essential to high quality care, uncertainty exists as to how intrahospital handover can be improved. This systematic review aims to evaluate the effectiveness of interventions aimed at improving the quality and/ or safety of the intrahospital handover process. Methods We searched for articles on handover improvement interventions in EMBASE, MEDLINE, HMIC and CINAHL between January 2002 and July 2012. We considered studies of: staff knowledge and skills, staff behavioural change, process change or patient outcomes. Results 631 potentially relevant papers were identified from which 29 papers were selected for inclusion (two randomised controlled trials and 27 uncontrolled studies). Most studies addressed shift-change handover and used a median of three outcome measures, but there was no outcome measure common to all. Poor study design and inconsistent reporting methods made it difficult to reach definite conclusions. Information transfer was improved in most relevant studies, while clinical outcome improvement was reported in only two of 10 studies. No difference was noted in the likelihood of success across four types of intervention. Conclusions The current literature does not confirm that any methodology reliably improves the outcomes of clinical handover, although information transfer may be increased. Better study designs and consistency of the terminology used to describe handover and its improvement are urgently required. [ABSTRACT FROM AUTHOR]
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- 2014
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76. Walking and child pedestrian injury: a systematic review of built environment correlates of safe walking.
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Rothman, Linda, Buliung, Ron, Macarthur, Colin, To, Teresa, and Howard, Andrew
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PREVENTION of injury ,CINAHL database ,CONFIDENCE intervals ,ECOLOGY ,EPIDEMIOLOGY ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,RESEARCH funding ,STATISTICS ,TRAFFIC accidents ,WALKING ,SYSTEMATIC reviews ,SEARCH engines ,DATA analysis ,SEVERITY of illness index ,CHILDREN - Abstract
Background: The child active transportation literature has focused on walking, with little attention to risk associated with increased traffic exposure. This paper reviews the literature related to built environment correlates of walking and pedestrian injury in children together, to broaden the current conceptualization of walkability to include injury prevention. Methods: Two independent searches were conducted focused on walking in children and child pedestrian injury within nine electronic databases until March, 2012. Studies were included which: 1) were quantitative 2) set in motorized countries 3) were either urban or suburban 4) investigated specific built environment risk factors 5) had outcomes of either walking in children and/or child pedestrian roadway collisions (ages 0-12). Built environment features were categorized according to those related to density, land use diversity or roadway design. Results were cross-tabulated to identify how built environment features associate with walking and injury. Results: Fifty walking and 35 child pedestrian injury studies were identified. Only traffic calming and presence of playgrounds/recreation areas were consistently associated with more walking and less pedestrian injury. Several built environment features were associated with more walking, but with increased injury. Many features had inconsistent results or had not been investigated for either outcome. Conclusions: The findings emphasise the importance of incorporating safety into the conversation about creating more walkable cities. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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77. The case for Ofsmoke: the potential for price cap regulation of tobacco to raise £500 million per year in the UK.
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Branston, J. Robert and Gilmor, Anna B.
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TOBACCO laws ,INDUSTRIES ,SMOKING ,PUBLIC administration ,RESEARCH funding ,DESCRIPTIVE statistics ,ECONOMICS - Abstract
Objective A system of price-cap regulation has previously been suggested to address the market failure inherent to the tobacco industry. This would benefit public health directly (eg, by making it extremely difficult for the industry to sell cut-price cigarettes, or use price as a marketing strategy) and indirectly (eg, by reducing the available money the industry has for spending on marketing and lobbying). This paper explores the feasibility of applying such a scheme in the UK. Methods The impact of price-capping is modelled using optimistic and conservative scenarios, each with different assumptions, and using 2009 and 2010 profit data for the major companies selling tobacco in the UK. The models are used to calculate by how much would profit be reduced through the imposition of price caps, and thus, how much revenue could be raised in additional taxes, assuming the end price the consumer pays does not change. Results Tobacco companies enjoy massive profit margins, up to 67%, in the UK. The optimistic scenario suggests a potential increase in UK tobacco tax revenue of £585.7 million in 2010 (£548.4 million in 2009), while the conservative model suggests an increase in revenue of £433.6 million in 2010 (£399.2 million in 2009). This would be approximately enough to fund, twice over, UK-wide antitobacco smuggling measures, and smoking cessation services in England, including the associated pharmacotherapies, to help people stop smoking. Conclusions Applying a system of price-cap regulation in the UK would raise around £500 million per annum (US$750 million). This is likely to be an underestimate because of cautious assumptions used in the model. These significant financial benefits, in addition to the public health benefits that would be generated, suggest this is a policy that should be given serious consideration. INSET: The price cap scheme and the benefits it would bring. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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78. Challenges for philanthropy and tobacco control in China (1986-2012).
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Redmon, Pamela, Chen, Lincoln C., Wood, Jacob L., Shuyang Li, and Koplan, Jeffrey P.
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SMOKING prevention ,CHARITY ,ENDOWMENTS ,INTERPROFESSIONAL relations ,INTERVIEWING ,RESEARCH methodology ,HEALTH outcome assessment ,PUBLIC health ,RESEARCH funding - Abstract
Objective To identify the international philanthropies that have invested in tobacco control in China, describe their role and strategies in changing the social norms of tobacco use, and define the outcomes achieved. Methods Information on the international philanthropic donor China projects, including activities and outcomes, was gathered from multiple sources including organisational websites, key informant interviews and emails with project officers, and published research papers and reports. Results Philanthropic donations to China's tobacco control efforts began in 1986. The donors provided funds to national, city, provincial government organisations, non-government organisations, universities, and healthcare organisations throughout China to establish a tobacco control workforce and effective programmes to reduce the burden of tobacco use. Conclusions International engagement has been an important dimension of tobacco control in China. Recognising the large burden of illness and capitalising on proven effective control measures, philanthropic organisations understandably seized the opportunity to achieve major health gains. Much of the international philanthropic investment has been directed at public information, policy change and building the Chinese research knowledge base. Documenting research and evaluation findings will continue to be important to ensure that promising practices and lessons learned are identified and shared with the China tobacco control practitioners. The ultimate question is whether foreign philanthropy is making a difference in tobacco control and changing social norms in China? The answer is plainly and simply that we do not know; the evidence is not yet available. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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79. Should anti-tobacco media messages be culturally targeted for Indigenous populations? A systematic review and narrative synthesis.
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Gould, Gillian Sandra, McEwen, Andy, Watters, Tracey, Clough, Alan R., and van der Zwan, Rick
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HEALTH promotion ,ASIANS ,CINAHL database ,COGNITION ,CULTURE ,ESKIMOS ,INDIGENOUS peoples of the Americas ,INDIGENOUS peoples ,MEDICAL information storage & retrieval systems ,PSYCHOLOGY information storage & retrieval systems ,INTENTION ,INTERNET ,MAORI (New Zealand people) ,MASS media ,MEDLINE ,HEALTH outcome assessment ,RADIO (Medium) ,RESEARCH funding ,SMOKING cessation ,TELEVISION ,TOBACCO ,WIRELESS communications ,PRINT materials ,HEALTH literacy ,DESCRIPTIVE statistics - Abstract
Objective To summarise published empirical research on culturally targeted anti-tobacco media messages for Indigenous or First Nations people and examine the evidence for the effectiveness of targeted and non-targeted campaigns. Methods Studies were sought describing mass media and new media interventions for tobacco control or smoking cessation in Indigenous or First Nations populations. Studies of any design were included reporting outcomes of media-based interventions including: cognitions, awareness, recall, intention to quit and quit rates. Then, 2 reviewers independently applied inclusion criteria, which were met by 21 (5.8%) of the studies found. One author extracted data with crosschecking by a second. Both independently assessed papers using Scottish Intercollegiate Guidelines Network (SIGN; quantitative studies) and Daly et al (qualitative studies). Results A total of 21 studies were found (4 level 1 randomised controlled trials (RCTs), 11 level 2 studies and 6 qualitative studies) and combined with narrative synthesis. Eight evaluated anti-tobacco TV or radio campaigns; two assessed US websites; three New Zealand studies examined mobile phone interventions; five evaluated print media; three evaluated a CD-ROM, a video and an edutainment intervention. Conclusions Although Indigenous people had good recall of generic anti-tobacco messages, culturally targeted messages were preferred. New Zealand Maori may be less responsive to holistic targeted campaigns, despite their additional benefits, compared to generic fear campaigns. Culturally targeted internet or mobile phone messages appear to be as effective in American Indians and Maori as generic messages in the general population. There is little research comparing the effect of culturally targeted versus generic messages with similar message content in Indigenous people. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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80. A systematic review of the aetiology of tobacco disparities for sexual minorities.
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Blosnich, John, Lee, Joseph G L, and Horn, Kimberly
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SMOKING ,CINAHL database ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,MINORITIES ,RESEARCH funding ,TOBACCO ,SYSTEMATIC reviews ,LGBTQ+ people ,HEALTH equity - Abstract
ObjectiveTo conduct a systematic review of the literature examining risk factors/correlates of cigarette smoking among lesbian, gay and bisexual (ie, sexual minority) populations.MethodsSets of terms relevant to sexual minority populations and cigarette smoking were used in a simultaneous search of 10 databases through EBSCOhost. The search was limited to the peer-reviewed literature up to January 2011, using no geographic or language limits. For inclusion, the paper was required to: (1) have been written in English, (2) have sexual minorities (defined by either attraction, behaviour, or identity) included in the study population and (3) have examined some form of magnitude of association for risk factors/correlates of any definition of cigarette smoking. A total of 386 abstracts were reviewed independently, with 26 papers meeting all inclusion criteria. Abstracts were reviewed and coded independently by authors JB and JGLL using nine codes derived from the inclusion/exclusion criteria.ResultsStudies used various measures of sexual orientation and of smoking. Risk factors that could be considered unique to sexual minorities included internalised homophobia and reactions to disclosure of sexual orientation. Some studies also indicated common smoking risk factors experienced at higher rates among sexual minorities, including stress, depression, alcohol use and victimisation.ConclusionsThis review identified risks that were associated with sexual minority status and common to the general population but experienced at potentially higher rates by sexual minorities. Government and foundation funds should be directed towards research on the origins of this disparity. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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81. Tobacco industry pricing strategies in response to excise tax policies: a systematic review.
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Sheikh, Zaineb Danish, Branston, J. Robert, and Gilmore, Anna B.
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TAX laws ,ONLINE information services ,MEDICAL information storage & retrieval systems ,MIDDLE-income countries ,DEVELOPED countries ,SYSTEMATIC reviews ,INDUSTRIES ,POPULATION geography ,GOVERNMENT policy ,DESCRIPTIVE statistics ,LOW-income countries ,RESEARCH funding ,TOBACCO products ,MEDLINE - Published
- 2023
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82. Structural stigma, sex work and HIV: contradictions and lessons learnt from a community-led structural intervention in southern India.
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Rao Biradavolu, Monica, Blankenship, Kim M., Jena, Asima, and Dhungana, Nimesh
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HIV prevention ,HEALTH services accessibility ,INTERVIEWING ,LONGITUDINAL method ,MEDICAL care use ,POWER (Social sciences) ,SEX work ,RESEARCH funding ,SOCIAL networks ,SOCIAL stigma ,QUALITATIVE research ,DISCLOSURE ,SOCIAL attitudes ,COMMUNITY-based social services ,HUMAN services programs ,REPEATED measures design ,PSYCHOLOGICAL vulnerability - Abstract
Background Recent theorisation has pushed stigma research in new directions, arguing for a need to challenge the unequal power relations that impact groups most at risk for HIV-related stigma rather than locate stigma in the individual. Such a conceptualisation resonates with the growing emphasis on structural interventions for HIV prevention that attempt to alter the social context of risk. Methods The paper predominantly relies on longitudinal interviews conducted three times over a 2-year period with sex workers with varying degrees of involvement with the non-governmental organisation (NGO) and community-based organisation. Results Recognising that stigma is socially constructed and structurally reproduced, the NGO helped mobilise marginalised and hitherto scattered female sex workers to form community-based organisations to challenge their disadvantaged status in society. The authors show how stigma alleviation strategies presented a contradiction: emboldening one group of female sex workers to self-identify as sex workers while making others reluctant to access the intervention-run clinic. Conclusion The paper builds on a growing body of research that acknowledges the struggles in implementing structural interventions, particularly for NGOs working in regions with a diverse population of sex workers with varying needs. The authors argue that intervention goals of reducing stigma and increasing the use of sexually transmitted infection services do not have to conflict and, in fact, must go hand-in-hand for an implementation to be considered a structural intervention. [ABSTRACT FROM AUTHOR]
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- 2012
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83. Tobacco industry attempts to influence and use the German government to undermine the WHO Framework Convention on Tobacco Control.
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Grüning, Thilo, Weishaar, Heide, Collin, Jeff, and Gilmore, Anna B.
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ADVERTISING & economics ,INDUSTRIES & economics ,SMOKING prevention ,DATABASES ,INTERNATIONAL relations ,LOBBYING ,HEALTH policy ,POLITICAL participation ,PRACTICAL politics ,RESEARCH funding ,STATISTICAL sampling ,SMOKING ,TOBACCO ,WORLD health ,QUALITATIVE research ,THEMATIC analysis - Abstract
Background Germany has been identified as one of a few high-income countries that opposed a strong Framework Convention on Tobacco Control (FCTC), the WHO's first global public health treaty. This paper examines whether the tobacco industry had influenced the German position on the FCTC. Methods Analysis of previously confidential tobacco industry documents. Results The tobacco industry has identified Germany as a key target within its global strategy against the FCTC. Building on an already supportive base, the industry appears to have successfully lobbied the German government, influencing Germany's position and argumentation on key aspects of the FCTC. It then used Germany in its efforts to weaken the FCTC. The evidence suggests that the industry enjoyed success in undermining the Federal Health Ministry's position and using Germany to limit the European Union negotiating mandate. The tactics used by the tobacco industry included the creation of controversy between the financial, trade and other ministries on one side and the health ministry on the other side, the use of business associations and other front groups to lobby on the industry's behalf and securing industry access to the FCTC negotiations via the International Standardization Organization. Conclusion The evidence suggests that Germany played a major role in the tobacco industry's efforts to undermine the FCTC. Germany's position consistently served to protect industry interests and was used to influence and constrain other countries. Germany thus contributed significantly to attempts to weaken an international treaty and, in doing so, failed in its responsibility to advance global health. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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84. Assessing housing quality and its impact on health, safety and sustainability.
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Keall, Michael, Baker, Michael G., Howden-Chapman, Philippa, Cunningham, Malcolm, and Ormandy, David
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ECOLOGY ,EXPERIMENTAL design ,HEALTH status indicators ,HOUSING ,RESEARCH methodology ,PATIENT safety ,QUESTIONNAIRES ,RESEARCH funding - Abstract
Background The adverse health and environmental effects of poor housing quality are well established. A central requirement for evidence-based policies and programmes to improve housing standards is a valid, reliable and practical way of measuring housing quality that is supported by policy agencies, the housing sector, researchers and the public. Methods This paper provides guidance on the development of housing quality-assessment tools that link practical measures of housing conditions to their effects on health, safety and sustainability, with particular reference to tools developed in New Zealand and England. Results The authors describe how information on housing quality can support individuals, agencies and the private sector to make worthwhile improvements to the health, safety and sustainability of housing. The information gathered and the resultant tools developed should be guided by the multiple purposes and end users of this information. Other important issues outlined include deciding on the scope, detailed content, practical administration issues and how the information will be analysed and summarised for its intended end users. There are likely to be considerable benefits from increased international collaboration and standardization of approaches to measuring housing hazards. At the same time, these assessment approaches need to consider local factors such as climate, geography, culture, predominating building practices, important housing-related health issues and existing building codes. Conclusions An effective housing quality-assessment tool has a central role in supporting improvements to housing. The issues discussed in this paper are designed to motivate and assist the development of such tools. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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85. De-implementing wisely: developing the evidence base to reduce low-value care.
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Grimshaw, Jeremy M., Patey, Andrea M., Kirkham, Kyle R., Hall, Amanda, Dowling, Shawn K., Rodondi, Nicolas, Ellen, Moriah, Kool, Tijn, Van Dulmen, Simone A., Kerr, Eve A., Linklater, Stefanie, Levinson, Wendy, and Bhatia, R. Sacha
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MEDICAL quality control ,PILOT projects ,PREOPERATIVE care ,SURGERY ,PATIENTS ,UNNECESSARY surgery ,MEDICAL care costs ,HUMAN services programs ,CONCEPTUAL structures ,HEALTH literacy ,QUALITY assurance ,CLINICAL competence ,RESEARCH funding ,HEALTH planning ,BEHAVIOR modification - Abstract
Choosing Wisely (CW) campaigns globally have focused attention on the need to reduce low-value care, which can represent up to 30% of the costs of healthcare. Despite early enthusiasm for the CW initiative, few large-scale changes in rates of low-value care have been reported since the launch of these campaigns. Recent commentaries suggest that the focus of the campaign should be on implementation of evidencebased strategies to effectively reduce low-value care. This paper describes the Choosing Wisely De-Implementation Framework (CWDIF), a novel framework that builds on previous work in the field of implementation science and proposes a comprehensive approach to systematically reduce low-value care in both hospital and community settings and advance the science of de-implementation. The CWDIF consists of five phases: Phase 0, identification of potential areas of low-value healthcare; Phase 1, identification of local priorities for implementation of CW recommendations; Phase 2, identification of barriers to implementing CW recommendations and potential interventions to overcome these; Phase 3, rigorous evaluations of CW implementation programmes; Phase 4, spread of effective CW implementation programmes. We provide a worked example of applying the CWDIF to develop and evaluate an implementation programme to reduce unnecessary preoperative testing in healthy patients undergoing low-risk surgeries and to further develop the evidence base to reduce low-value care. [ABSTRACT FROM AUTHOR]
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- 2020
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86. Promoting convergence and closing gaps: a blueprint for the revision of the European Union Tobacco Tax Directive.
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López-Nicolás, Ángel and Branston, J. Robert
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TAXATION ,GOVERNMENT policy ,COST analysis ,RESEARCH funding ,TOBACCO products ,POLICY sciences ,STATISTICAL models ,LONGITUDINAL method - Published
- 2023
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87. Complex PrEP: the factors requiring consultant-led review of PrEP users.
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Tittle, Victoria, Dalton, Rebecca, Nugent, Diarmuid, Girometti, Nicolo, Whitlock, Gary, Mcowan, Alan, McCormack, Sheena, and Dean Street Collaborative Group
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HIV prevention ,NATIONAL health services ,MEDICAL consultants ,RESEARCH funding ,HIV infections ,RETROSPECTIVE studies ,ANTI-HIV agents ,PREVENTIVE health services - Abstract
Introduction: HIV-1 pre-exposure prophylaxis (PrEP) has been available in England since March 2020 on the National Health Service using generic emtricitabine and tenofovir disoproxil. 56 Dean Street (56DS) provided PrEP through (1) additional private care from September 2015, estimated to be providing 11% of England's PrEP in 2019; and (2) the IMPACT trial, as well as monitoring those self-sourcing PrEP. Providing PrEP at scale through a nurse-led service required a safety net for complex individuals. 56DS introduced a consultant-led PrEP outpatient service, the PrEP review clinic, in January 2018 and we report the outcomes of this service.Methods: We present a retrospective case note review of the PrEP review clinic with descriptive outcomes from 26 January 2018 to 20 December 2019. Reason for referral, demographics, PrEP management and PrEP discontinuations were recorded.Results: 13 980 unique users accessed PrEP from 56DS during the two year evaluation period. 220 individuals were seen in the PrEP review clinic. Majority of patients were referred for renal issues (114 of 220, 51.8%), followed by side effects (59 of 220, 26.8%) and comorbidities (38 of 220, 17.2%). Of those with renal issues, 89 (out of 114, 78.1%) users were referred for an abnormal estimated glomerular filtration rate (eGFR). 35 (out of 114, 30.7%) PrEP users had an eGFR between 45 and 59 mL/min/1.73 m2, of whom 2 (5.7%) discontinued PrEP. Majority of users were advised to stop supplements±switch to event-based dosing (24 of 35, 68.6%). Ten PrEP users were referred with an eGFR between 30 and 44 mL/min/1.73 m2; 4 (40%) stopped or did not start PrEP and 6 (60%) were asked to stop supplements±switch to event-based dosing.Discussion: A small proportion of PrEP users have complex PrEP issues. Methods to manage renal dysfunction with PrEP included stopping supplements and switching to event-based dosing. Those with side effects were managed with an array of options, with only modest effectiveness. Other PrEP options are needed to support those with toxicities or intolerances. [ABSTRACT FROM AUTHOR]- Published
- 2022
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88. The determinants of transitions into sheltered accommodation in later life in England and Wales.
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Vlachantoni, Athina, Maslovskaya, Olga, Evandrou, Maria, and Falkingham, Jane
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AGING ,CHI-squared test ,CONFIDENCE intervals ,DEMOGRAPHY ,HEALTH status indicators ,LONGITUDINAL method ,MATHEMATICAL models ,QUESTIONNAIRES ,RESEARCH funding ,SURVEYS ,LOGISTIC regression analysis ,THEORY ,SOCIOECONOMIC factors ,RESIDENTIAL care ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio - Abstract
Background Population ageing is a global challenge and understanding the dynamics of living arrangements in later life and their implications for the design of appropriate housing and long-term care is a critical policy issue. Existing research has focused on the study of transitions into residential care in the UK. This paper investigates transitions into sheltered accommodation among older people in England and Wales between 1993 and 2008. Methods The study uses longitudinal data constructed from pooled observations across waves 2-18 of the British Household Panel Survey (BHPS) data, focusing on individuals aged 65 and over who lived in private housing at baseline and who were observed for two consecutive time points. A discrete-time logistic regression model was used to examine the association of transitioning into sheltered accommodation with a range of demographic, health and socioeconomic predictors. Results Demographic (age, region), socioeconomic factors (housing tenure, having a washing machine) and contact with health professionals (number of visits to the general practitioner, start in use of health visitor) were significant determinants of an older person's move into sheltered accommodation. Conclusions Transitions into sheltered accommodation are associated with a range of demographic and socioeconomic characteristics as well as service use but not with health. Such results indicate that this type of housing option may be accessible by individuals with relatively good health, but may be limited to those who are referred by gatekeepers. Policymakers could consider making such housing option available to everyone, as well as providing incentives for building lifecourse-sensitive housing in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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89. Investment incentives and the implementation of the Framework Convention on Tobacco Control: evidence from Zambia.
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Lencucha, Raphael, Drope, Jeffrey, Labonte, Ronald, Zulu, Richard, and Goma, Fastone
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PUBLIC administration ,SMOKING prevention ,DOCUMENTATION ,GOAL (Psychology) ,INDUSTRIES ,INTERVIEWING ,RESEARCH methodology ,PUBLIC health ,RESEARCH funding ,TOBACCO ,GOVERNMENT policy ,THEMATIC analysis ,HUMAN services programs ,DATA analysis software ,ECONOMICS - Abstract
Purpose Policy misalignment across different sectors of government serves as one of the pivotal barriers to WHO Framework Convention on Tobacco Control (FCTC) implementation. This paper examines the logic used by government officials to justify investment incentives to increase tobacco processing and manufacturing in the context of FCTC implementation in Zambia. Methods We conducted qualitative semistructured interviews with key informants from government, civil society and intergovernmental economic organisations (n=23). We supplemented the interview data with an analysis of public documents pertaining to the policy of economic development in Zambia. Results We found gross misalignments between the policies of the economic sector and efforts to implement the provisions of the FCTC. Our interviews uncovered the rationale used by officials in the economic sector to justify providing economic incentives to bolster tobacco processing and manufacturing in Zambia: (1) tobacco is not consumed by Zambians/tobacco is an export commodity, (2) economic benefits outweigh health costs and (3) tobacco consumption is a personal choice. Conclusions Much of the struggle Zambia has experienced in implementing the FCTC can be attributed to misalignments between the economic and health sectors. Zambia's development agenda seeks to bolster agricultural processing and manufacturing. Tobacco control proponents must recognise and work within this context in order to foster productive strategies with those working on tobacco supply issues. These findings are broadly applicable to the global context. It is important that the Ministry of Health monitors the tobacco policy of and engages with these sectors to find ways of harmonising FCTC implementation. [ABSTRACT FROM AUTHOR]
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- 2016
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90. Ethnic inequalities in limiting health and self-reported health in later life revisited.
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Evandrou, Maria, Falkingham, Jane, Zhixin Feng, and Vlachantoni, Athina
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AGE distribution ,GERIATRIC psychology ,CONFIDENCE intervals ,ETHNIC groups ,MINORITIES ,RESEARCH funding ,SELF-evaluation ,LOGISTIC regression analysis ,SOCIOECONOMIC factors ,HEALTH equity ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio - Abstract
Background It is well established that there are ethnic inequalities in health in the UK; however, such inequalities in later life remain a relatively under-researched area. This paper explores ethnic inequalities in health among older people in the UK, controlling for social and economic disadvantages. Methods This paper analyses the first wave (2009-2011) of Understanding Society to examine differentials in the health of older persons aged 60 years and over. 2 health outcomes are explored: the extent to which one's health limits the ability to undertake typical activities and self-rated health. Logistic regression models are used to control for a range of other factors, including income and deprivation. Results After controlling for social and economic disadvantage, black and minority ethnic (BME) elders are still more likely than white British elders to report limiting health and poor self-rated health. The 'health disadvantage' appears most marked among BME elders of South Asian origin, with Pakistani elders exhibiting the poorest health outcomes. Length of time resident in the UK does not have a direct impact on health in models for both genders, but is marginally significant for women. Conclusions Older people from ethnic minorities report poorer health outcomes even after controlling for social and economic disadvantages. This result reflects the complexity of health inequalities among different ethnic groups in the UK, and the need to develop health policies which take into account differences in social and economic resources between different ethnic groups. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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91. Development of a cross-cultural deprivation index in five European countries.
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Guillaume, Elodie, Pornet, Carole, Dejardin, Olivier, Launay, Ludivine, Lillini, Roberto, Vercelli, Marina, Marí-Dell'Olmo, Marc, Fernández Fontelo, Amanda, Borrell, Carme, Ribeiro, Ana Isabel, de Pina, Maria Fatima, Mayer, Alexandra, Delpierre, Cyrille, Rachet, Bernard, and Launoy, Guy
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POLICY sciences ,HEALTH services accessibility ,HEALTH status indicators ,NEEDS assessment ,POVERTY ,PROBABILITY theory ,QUESTIONNAIRES ,RESEARCH funding ,PSYCHOLOGY of the sick ,LOGISTIC regression analysis ,SOCIOECONOMIC factors ,HEALTH equity ,RESEARCH methodology evaluation ,PSYCHOLOGY - Abstract
Background Despite a concerted policy effort in Europe, social inequalities in health are a persistent problem. Developing a standardised measure of socioeconomic level across Europe will improve the understanding of the underlying mechanisms and causes of inequalities. This will facilitate developing, implementing and assessing new and more effective policies, and will improve the comparability and reproducibility of health inequality studies among countries. This paper presents the extension of the European Deprivation Index (EDI), a standardised measure first developed in France, to four other European countries--Italy, Portugal, Spain and England, using available 2001 and 1999 national census data. Methods and results The method previously tested and validated to construct the French EDI was used: first, an individual indicator for relative deprivation was constructed, defined by the minimal number of unmet fundamental needs associated with both objective (income) poverty and subjective poverty. Second, variables available at both individual (European survey) and aggregate (census) levels were identified. Third, an ecological deprivation index was constructed by selecting the set of weighted variables from the second step that best correlated with the individual deprivation indicator. Conclusions For each country, the EDI is a weighted combination of aggregated variables from the national census that are most highly correlated with a country-specific individual deprivation indicator. This tool will improve both the historical and international comparability of studies, our understanding of the mechanisms underlying social inequalities in health and implementation of intervention to tackle social inequalities in health. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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92. Harnessing information from injury narratives in the 'big data' era: understanding and applying machine learning for injury surveillance.
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Vallmuur, Kirsten, Marucci-Wellman, Helen R., Taylor, Jennifer A., Lehto, Mark, Corns, Helen L., and Smith, Gordon S.
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PREVENTION of injury ,WOUND & injury classification ,ALGORITHMS ,CHI-squared test ,CONFIDENCE intervals ,DATABASES ,HEALTH ,CASE studies ,PUBLIC health surveillance ,RESEARCH funding ,STATISTICS ,ACCESS to information ,NARRATIVES ,ACQUISITION of data ,MEDICAL coding - Abstract
Objective Vast amounts of injury narratives are collected daily and are available electronically in real time and have great potential for use in injury surveillance and evaluation. Machine learning algorithms have been developed to assist in identifying cases and classifying mechanisms leading to injury in a much timelier manner than is possible when relying on manua coding of narratives. The aim of this paper is to describe the background, growth, value, challenges and future directions of machine learning as applied to injury surveillance. Methods This paper reviews key aspects of machine learning using injury narratives, providing a case study to demonstrate an application to an established human-machine learning approach. Results The range of applications and utility of narrative text has increased greatly with advancements in computing techniques over time. Practical and feasible methods exist for semiautomatic classification of injury narratives which are accurate, efficient and meaningful. The human-machine learning approach described in the case study achieved high sensitivity and PPV and reduced the need for human coding to less than a third of cases in one large occupational injury database. Conclusions The last 20 years have seen a dramatic change in the potential for technological advancements in injury surveillance. Machine learning of 'big injury narrative data' opens up many possibilities for expanded sources of data which can provide more comprehensive, ongoing and timely surveillance to inform future injury prevention policy and practice. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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93. Prevalence and associated harm of engagement in self-asphyxial behaviours ('choking game') in young people: a systematic review.
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Busse, H., Harrop, T., Gunnell, D., and Kipping, R.
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DISEASE prevalence ,CHILD mortality ,HUMAN behavior ,PUBLIC health ,JUVENILE diseases ,RESEARCH funding ,RESPIRATORY obstructions ,RISK-taking behavior ,SELF-injurious behavior ,TEENAGERS' conduct of life ,SYSTEMATIC reviews - Abstract
Objective: To assess the prevalence of engagement in self-asphyxial (risk-taking) behaviour (SAB) ('choking game') and associated morbidity and mortality in children and young people up to age 20.Design: Systematic literature review.Search Strategy: Electronic database search of MEDLINE, Embase, PsycINFO, CINAHL, PubMed, Web of Science Core Collection, BIOSIS citation index and the Cochrane register with no language or date limits applied. References of key papers were reviewed, and experts were contacted to identify additional relevant papers.Eligibility Criteria: Systematic reviews, cross-sectional, cohort and case-control studies, and case reports examining SAB with regard to individuals aged 0-20 years, without explicitly stated autoerotic, suicidal or self-harm intentions were included.Results: Thirty-six relevant studies were identified, and SAB was reported in 10 countries. In North America, France and Colombia, awareness of SAB ranged from 36% to 91% across studies/settings, and the median lifetime prevalence of engagement in SAB was 7.4%. Six studies identified the potential for SAB to be associated with engagement in other risk behaviours. Ninety-nine fatal cases were reported. Of the 24 cases described in detail, most occurred when individuals engaged in SAB alone and used a ligature.Conclusions: The current evidence on SAB among young people is limited, and stems predominantly from North America and France. Awareness of SAB among young people is high, and engagement varies by setting. Further research is needed to understand the level of risk and harm associated with SAB, and to determine the appropriate public health response. [ABSTRACT FROM AUTHOR]- Published
- 2015
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94. Assessing quality of direct-to-consumer telemedicine in China: a cross-sectional study using unannounced standardised patients.
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Zhen Zeng, Xu, Dong (Roman), Yiyuan Cai, and Wenjie Gong
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CROSS-sectional method ,CHINESE medicine ,COLD (Temperature) ,ANGINA pectoris ,DIARRHEA ,URINARY stress incontinence ,HEALTH services accessibility ,MEDICAL protocols ,MEDICAL care use ,MEDICAL quality control ,SKIN inflammation ,MEDICAL personnel ,SATISFACTION ,RESEARCH funding ,MEDICAL care ,LOGISTIC regression analysis ,POSTPARTUM depression ,INTERNET ,EVALUATION of medical care ,DESCRIPTIVE statistics ,TELEMEDICINE ,MEDICAL consultation ,PATIENT-centered care ,SIMULATED patients ,CONCEPTUAL structures ,RESEARCH methodology ,GASTRITIS ,QUALITY assurance ,COUNSELING ,COMPARATIVE studies ,CONFIDENCE intervals ,DATA analysis software ,MEDICAL referrals ,DIABETES ,ASTHMA ,LUMBAR pain ,PSYCHOSOCIAL factors ,SYMPTOMS ,CHILDREN - Abstract
Direct-to-onsumer telemedicine (DTCT) has become popular as an alternative to traditional care. However, uncertainties about the potential risks associated with the lack of comprehensive quality evaluation could influence its long-term development. This study aimed to assess the quality of care provided by DTCT platforms in China using unannounced standardised patients (USP) between July 2021 and January 2022. The study assessed consultation services on both hospital and enterprise-sponsored platforms using the Institute of Medicine quality framework. It employed 10 USP cases, covering conditions such as diabetes, asthma, common cold, gastritis, angina, low back pain, child diarrhoea, child dermatitis, stress urinary incontinence and postpartum depression. Descriptive and regression analyses were employed to examine platform characteristics and compare quality across platform types. The results showed that of 170 USP visits across 107 different telemedicine platforms, enterprise-sponsored platforms achieved a 100% success in access, while hospital-sponsored platforms had a success rate of only 47.5% (56/118). Analysis highlighted a low overall correct diagnosis rate of 45% and inadequate adherence to clinical guidelines across all platforms. Notably, enterprise-sponsored platforms outperformed in accessibility, response time and case management compared with hospital-sponsored platforms. This study highlights the suboptimal quality of DTCT platforms in China, particularly for hospital-sponsored platforms. To further enhance DTCT services, future studies should compare DTCT and in-person care, aiming to identify gaps and potential risks associated with using DTCT as alternatives or supplements to traditional care. The potential of future development in enhancing DTCT services may involve exploring the integration of hospital resources with the technology and market capabilities of enterprise-sponsored platforms. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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95. Patient safety in remote primary care encounters: multimethod qualitative study combining Safety I and Safety II analysis.
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Payne, Rebecca, Clarke, Aileen, Swann, Nadia, van Dael, Jackie, Brenman, Natassia, Rosen, Rebecca, Mackridge, Adam, Moore, Lucy, Kalin, Asli, Ladds, Emma, Hemmings, Nina, Rybczynska-Bunt, Sarah, Faulkner, Stuart, Hanson, Isabel, Spitters, Sophie, Wieringa, Sietse, Dakin, Francesca H., Shaw, Sara E., Wherton, Joseph, and Byng, Richard
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PATIENT safety ,RESEARCH funding ,PRIMARY health care ,INTERVIEWING ,ETHNOLOGY research ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,TELEMEDICINE ,MEDICAL consultation ,LONGITUDINAL method ,THEMATIC analysis ,RESEARCH methodology ,MEDICAL records ,ACQUISITION of data ,LABOR demand ,DELAYED diagnosis ,DATA analysis software ,CASE studies ,MEDICAL referrals - Abstract
Background Triage and clinical consultations increasingly occur remotely. We aimed to learn why safety incidents occur in remote encounters and how to prevent them. Setting and sample UK primary care. 95 safety incidents (complaints, settled indemnity claims and reports) involving remote interactions. Separately, 12 general practices followed 2021-2023. Methods Multimethod qualitative study. We explored causes of real safety incidents retrospectively ('Safety I' analysis). In a prospective longitudinal study, we used interviews and ethnographic observation to produce individual, organisational and system-level explanations for why safety and near-miss incidents (rarely) occurred and why they did not occur more often ('Safety II' analysis). Data were analysed thematically. An interpretive synthesis of why safety incidents occur, and why they do not occur more often, was refined following member checking with safety experts and lived experience experts. Results Safety incidents were characterised by inappropriate modality, poor rapport building, inadequate information gathering, limited clinical assessment, inappropriate pathway (eg, wrong algorithm) and inadequate attention to social circumstances. These resulted in missed, inaccurate or delayed diagnoses, underestimation of severity or urgency, delayed referral, incorrect or delayed treatment, poor safety netting and inadequate follow-up. Patients with complex pre-existing conditions, cardiac or abdominal emergencies, vague or generalised symptoms, safeguarding issues, failure to respond to previous treatment or difficulty communicating seemed especially vulnerable. General practices were facing resource constraints, understaffing and high demand. Triage and care pathways were complex, hard to navigate and involved multiple staff. In this context, patient safety often depended on individual staff taking initiative, speaking up or personalising solutions. Conclusion While safety incidents are extremely rare in remote primary care, deaths and serious harms have resulted. We offer suggestions for patient, staff and system-level mitigations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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96. Calcification is a risk factor for intracranial in-stent restenosis: an optical coherence tomography study.
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Tianhua Li, Ran Xu, Yan Ma, Tao Wang, Bin Yang, and Liqun Jiao
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RISK assessment ,RESEARCH funding ,OPTICAL coherence tomography ,CALCINOSIS ,SURGICAL stents ,DESCRIPTIVE statistics ,COLOR Doppler ultrasonography ,TRANSCRANIAL Doppler ultrasonography ,INTRACRANIAL arterial diseases ,DISEASE relapse ,DISEASE risk factors - Abstract
Background The frequent occurrence of calcification in intracranial artery stenosis increases the risk of ischemic stroke. In previous cases, we have observed a possible relationship between calcification and intracranial in-stent restenosis (ISR) using optical coherence tomography (OCT). Therefore, our study aimed to demonstrate the relationship between intracranial calcification and ISR with a larger sample size. Methods For our study patients who underwent OCT for intracranial artery stenosis before stenting were included from May 2020 to October 2022. Follow-up assessments were performed using transcranial color-coded duplex (TCCD) sonography ultrasonography to detect cases of ISR. Results We recruited 54 patients, 15 of them were excluded as they did not meet the study criteria. Our study included 39 patients, of whom 21 had calcification, and 18 did not. The results of our study revealed a significant association between calcification and intracranial ISR (9 (42.86) vs 2 (11.11), p=0.0375). Notably, patients with macrocalcification were more likely to undergo ISR than patients with spotty calcification (77.78% vs 22.22%, p=0.03). Conclusion OCT imaging demonstrates that calcification is an essential risk factor for intracranial ISR. These findings have important implications for individualized treatment. They provide valuable insights for optimizing stent design and exploring potential mechanisms of intracranial ISR. Trial registration number ClinicalTrials. gov Identifier: NCT05550077. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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97. A novel intrasaccular aneurysm device with high complete occlusion rate: initial results in a rabbit model.
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Zoppo, Christopher T., Kolstad, Josephine W., King, Robert M., Wolfe, Thomas, Kraitem, Afif, Vardar, Zeynep, Badruddin, Aamir, Pereira, Edgard, Guerrero, Boris Pabón, Rosqueta, Arturo S., Ughi, Giovanni J., Gounis, Matthew J., Zaidat, Osama O., and Anagnostakou, Vania
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INTRACRANIAL aneurysm surgery ,INTRACRANIAL aneurysms ,RESEARCH funding ,OPTICAL coherence tomography ,BLOOD vessel prosthesis ,SURGICAL stents ,ENDOVASCULAR surgery ,TREATMENT effectiveness ,DIGITAL subtraction angiography ,DESCRIPTIVE statistics ,ANIMAL experimentation ,PROTEOLYTIC enzymes ,COMPARATIVE studies ,POSTOPERATIVE period ,RABBITS ,EVALUATION - Abstract
Background Intrasaccular flow-disrupting devices are a safe and effective treatment strategy for intracranial aneurysms. We utilized high-frequency optical coherence tomography (HF-OCT) and digital subtraction angiography (DSA) to evaluate SEAL Arc, a new intrasaccular device, and compare the findings with the well-established Woven EndoBridge (WEB) device in an animal model of saccular aneurysms. Methods In a rabbit model, elastase-induced aneurysms were treated with SEAL Arc (n=11) devices. HF-OCT and DSA were performed after implant and repeated after 12 weeks. Device protrusion and malapposition were assessed at implant time and scored on a binary system. Aneurysm occlusion was assessed at 12 weeks with the WEB Occlusion Scale and dichotomized to complete (A and B) or incomplete (C and D) occlusion. The percentage of neointimal coverage after 12 weeks was quantified using HF-OCT. We compared these data to previously published historical controls treated with the gold-standard WEB device (n=24) in the same model. Results Aneurysm size and device placement were not significantly different between the two groups. Complete occlusion was demonstrated in 80% of the SEAL Arc devices, which compared favorably to the 21% of the aneurysms treated with WEB devices (P=0.002). Neointimal coverage across SEAL Arc devices was 86±15% compared with 49±27% for WEB (P=0.001). Protruding devices had significantly less neointimal coverage (P<0.001) as did incompletely occluded aneurysms (P<0.001). Histologically, all aneurysms treated with SEAL Arc devices were completely healed. Conclusion Complete early aneurysm occlusion was frequently observed in the SEAL Arc treated aneurysms, with significant neointimal coverage after 12 weeks. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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98. Universal Credit receipt among working-age patients who are accessing specialist mental health services: results from a novel data linkage study.
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Stevelink, Sharon A. M., Bakolis, Ioannis, Dorrington, Sarah, Downs, Johnny, Leal, Ray, Madan, Ira, Phillips, Ava, Geiger, Ben, Hotopf, Matthew, and Fear, Nicola T.
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MENTAL illness treatment ,SOCIAL security ,HEALTH services accessibility ,MEDICAL care use ,SEMANTIC Web ,MENTAL health services ,MEDICAL specialties & specialists ,RESEARCH funding ,LOGISTIC regression analysis ,SEX distribution ,AGE distribution ,DESCRIPTIVE statistics ,ELECTRONIC health records ,SOCIODEMOGRAPHIC factors ,CONFIDENCE intervals ,EMPLOYMENT ,TIME ,SOCIAL isolation - Published
- 2024
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99. Trends in educational inequalities in smoking-attributable mortality and their impact on changes in general mortality inequalities: evidence from England and Wales, Finland, and Italy (Turin).
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Van Hemelrijck, Wanda Monika Johanna, Kunst, Anton E., Sizer, Alison, Martikainen, Pekka, Zengarini, Nicolas, Costa, Giuseppe, and Janssen, Fanny
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MORTALITY ,RESEARCH funding ,SMOKING ,SOCIOECONOMIC factors ,EDUCATIONAL attainment ,REGRESSION analysis - Published
- 2024
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100. In vitro and in silico assessment of flow modulation after deploying the Contour Neurovascular System in intracranial aneurysm models.
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Korte, Jana, Gaidzik, Franziska, Larsen, Naomi, Schütz, Erik, Damm, Timo, Wodarg, Fritz, Hövener, Jan-Bernd, Jansen, Olav, Janiga, Gábor, Berg, Philipp, and Pravdivtseva, Mariya S.
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INTRACRANIAL aneurysm surgery ,IN vitro studies ,COMPUTER simulation ,RESEARCH funding ,PATIENT safety ,HEMODYNAMICS ,TREATMENT effectiveness ,ENDOVASCULAR surgery ,MAGNETIC resonance imaging ,DESCRIPTIVE statistics ,BLOOD flow measurement ,POSTERIOR cerebral artery ,CEREBRAL circulation ,SURGICAL meshes - Abstract
Background The novel Contour Neurovascular System (Contour) has been reported to be efficient and safe for the treatment of intracranial, wide-necked bifurcation aneurysms. Flow in the aneurysm and posterior cerebral arteries (PCAs) after Contour deployment has not been analyzed in detail yet. However, this information is crucial for predicting aneurysm treatment outcomes. Methods Time-resolved three-dimensional velocity maps in 14 combinations of patient-based basilar tip aneurysm models with and without Contour devices (sizes between 5 and 14 mm) were analyzed using four-dimensionsal (4D) flow MRI and numerical/image-based flow simulations. A complex virtual processing pipeline was developed to mimic the experimental shape and position of the Contour together with the simulations. Results On average, the Contour significantly reduced intra-aneurysmal flow velocity by 67% (mean w/ = 0.03m/s; mean w/o = 0.12m/s; p-value=0.002), and the time-averaged wall shear stress by more than 87% (mean w/ = 0.17Pa; mean w/o = 1.35Pa; pvalue= 0.002), as observed by numerical simulations. Furthermore, a significant reduction in flow (P<0.01) was confirmed by the neck inflow rate, kinetic energy, and inflow concentration index after Contour deployment. Notably, device size has a stronger effect on reducing flow than device positioning. However, positioning affected flow in the PCAs, while being robust in effectively reducing flow. Conclusions This study showed the high efficacy of the Contour device in reducing flow within aneurysms regardless of the exact position. However, we observed an effect on the flow in PCAs, which needs to be investigated further. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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