1. Ibrutinib-induced spinal haematoma in a patient with marginal zone lymphoma.
- Author
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Vojjala N, Roberson F, Yadav SK, and Krishnamoorthy G
- Subjects
- Humans, Female, Magnetic Resonance Imaging, Pyrimidines adverse effects, Pyrimidines therapeutic use, Spinal Cord Compression chemically induced, Spinal Cord Compression diagnostic imaging, Aged, Hematoma, Epidural, Spinal chemically induced, Hematoma, Epidural, Spinal diagnostic imaging, Piperidines adverse effects, Adenine analogs & derivatives, Adenine adverse effects, Lymphoma, B-Cell, Marginal Zone drug therapy, Pyrazoles adverse effects
- Abstract
Bleeding diathesis is an uncommon side effect of ibrutinib use and is seen in less than 5% of the population. We describe a case of an elderly woman with ibrutinib-induced spontaneous major extradural haematoma presenting as acute compressive myelopathy. She is a known case of splenic marginal zone lymphoma with multiple extramedullary relapses and presented to the emergency department with acute-onset low backache, followed by urinary retention. MRI revealed extradural haemorrhage. After possible evaluation, she was diagnosed with ibrutinib-induced extradural haematoma., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
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