1. Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study
- Author
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F. Soscia, F. Gragnani, Franco Giubilei, Francesca Caramia, Marco Fiorelli, A Di Pasquale, V. Ceschin, Stefania Morino, Caterina Mainero, Andrea Romano, and Giovanni Antonini
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Middle temporal gyrus ,Short Report ,Biology ,Grey matter ,Brain mapping ,Atrophy ,Imaging, Three-Dimensional ,Trinucleotide Repeats ,Reference Values ,medicine ,Image Processing, Computer-Assisted ,Humans ,Myotonic Dystrophy ,Mathematical Computing ,Genes, Dominant ,Cerebral atrophy ,Cerebral Cortex ,Chromosome Aberrations ,Neurologic Examination ,Brain Mapping ,Voxel-based morphometry ,Anatomy ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Hyperintensity ,Psychiatry and Mental health ,medicine.anatomical_structure ,Cerebral cortex ,Disease Progression ,Surgery ,Female ,Neurology (clinical) ,Chromosomes, Human, Pair 19 ,Software - Abstract
Brain involvement in myotonic dystrophy type 1 (DM1) is characterised by cortical atrophy and white matter lesions. We compared the magnetic resonance imaging derived grey matter maps of 22 DM1 patients with those of matched, healthy controls using voxel based morphometry to evaluate the extension of global and regional cortical atrophy in DM1, as well as its relationships with clinical and genetic features. Patients had significantly reduced brain tissue volumes. Grey matter volume was inversely correlated with age; this inverse correlation was significantly stronger in DM1 than in controls. Neither the clinical and genetic characteristics nor white matter lesions were correlated with cortical atrophy. Grey matter atrophy was located mainly in the bilateral frontal and parietal lobes, in the bilateral middle temporal gyrus, and in the left superior temporal and occipital gyrus.
- Published
- 2004