1. Electroacupuncture for stress-related urinary incontinence in elderly women: data analysis from two randomised controlled studies
- Author
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Yan Liu, Zhishun Liu, Tongsheng Su, Yuanjie Sun, and Biyun Sun
- Subjects
Data Analysis ,Male ,medicine.medical_specialty ,Electroacupuncture ,Urinary Incontinence, Stress ,medicine.medical_treatment ,Medicine (miscellaneous) ,Urinary incontinence ,030204 cardiovascular system & hematology ,Controlled studies ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Internal medicine ,medicine ,Acupuncture ,Humans ,030212 general & internal medicine ,Adverse effect ,Aged ,Oncology (nursing) ,business.industry ,General Medicine ,Middle Aged ,Pad test ,Medical–Surgical Nursing ,Regimen ,Treatment Outcome ,Urinary Incontinence ,Sample size determination ,Female ,medicine.symptom ,business - Abstract
ObjectiveTo compare the efficacy of electroacupuncture (EA) in elderly and non-elderly women with stress urinary incontinence (SUI) or stress-predominant mixed urinary incontinence (MUI).MethodsThis study was a secondary analysis of two randomised controlled trials involving 252 women with SUI and 132 women with stress-predominant MUI who were treated with the same EA regimen. Elderly women were defined as those aged >60 years. The main outcome measure was the proportion of patients with ≥50% decrease in the mean 72-hour urinary incontinence episode frequency (IEF) from baseline to week 6. Overall, 1004 women were recruited in the SUI and MUI trials. In the EA group, those with urge-predominant or balanced MUI at baseline were excluded from the current study, resulting in a sample size of 384.ResultsOut of 384 patients with SUI or stress-predominant MUI who were treated with EA, 371 completed the study. After 6-week treatment, the proportion of women who achieved ≥50% decrease in mean 72-hour IEF from baseline was 57.3% (51/89) in the elderly group and 60.70% (173/285) in the non-elderly group; the between-group difference was not significant (3.11%, 95% CI −9.83% to 16.05%; p=0.637). Similar outcomes were observed at weeks 4, 16 and 28. Both groups showed reduction in the 72 -hour IEF, amount of urine leakage (assessed by 1-hour pad test) and International Consultation on Incontinence Questionnaire-Short Form score from baseline with no significant between-group difference. No obvious EA-related adverse events were observed during the study.ConclusionEA may be an effective and safe alternative treatment for SUI or stress-predominant MUI in both elderly and non-elderly women. Age may not affect the treatment outcomes of acupuncture.Trial registration numerNCT01784172, NCT02047032.
- Published
- 2020
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