1. Prognostic factors in microinvasive cervical squamous cell cancer: long-term results
- Author
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Francesco Raspagliesi, Antonino Ditto, Marialuisa Carcangiu, Rosanna Fontanelli, Pasquale Quattrone, V. Dousias, S. Kusamura, and Eugenio Solima
- Subjects
Adult ,medicine.medical_specialty ,Time Factors ,Urology ,Conization ,Uterine Cervical Neoplasms ,Cervix Uteri ,Microinvasive carcinoma ,medicine ,Carcinoma ,Humans ,Neoplasm Invasiveness ,Cervix ,Diagnostic Techniques, Obstetrical and Gynecological ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Cervical squamous cell cancer ,Obstetrics and Gynecology ,Retrospective cohort study ,Long term results ,medicine.disease ,Prognosis ,Apex (geometry) ,Surgery ,medicine.anatomical_structure ,Oncology ,Carcinoma, Squamous Cell ,Female ,Neoplasm Recurrence, Local ,business ,Carcinoma in Situ ,Microinvasive Squamous Cell Carcinoma - Abstract
We examined tumor-related pathologic factors and cone-related characteristics to identify parameters related to recurrence in microinvasive squamous cell carcinoma of the cervix treated with conization. This is a retrospective study on 67 consecutive cases of microinvasive carcinoma of the cervix [depth of invasion (DI) P < 0.05). The mean distance between tumor margin and apex of the cone (apical clearance) was 10.6 mm (range 5–22 mm), and the mean distance between lateral border of the cone and tumor margin (lateral clearance) was 6.5 mm (range 1.7–15 mm). We adopted cut-off values of 10 and 8 mm for apical and lateral clearances, respectively. We found a statistically significant difference between apical clearance and recurrence rate (P < 0.02). The LVSI was, other than DI, an important prognostic factor. Apical clearance was significantly correlated with recurrence. The cone-related characteristics, other than tumor-related pathologic factors, could help the decision concerning the definitive therapy for microinvasive carcinoma of the cervix.
- Published
- 2005
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