1. Evidence suggests dabigatran is an effective and safe treatment for patients with VTE requiring early parenteral therapy
- Author
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Alexander T. Cohen and Serena Granziera
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Deep vein ,Hemorrhage ,Gastroenterology ,Antithrombins ,Dabigatran ,Internal medicine ,Humans ,Medicine ,Stroke ,business.industry ,Warfarin ,Anticoagulants ,Venous Thromboembolism ,General Medicine ,Vitamin K antagonist ,medicine.disease ,Thrombosis ,Pulmonary embolism ,Surgery ,medicine.anatomical_structure ,beta-Alanine ,Benzimidazoles ,Female ,business ,Venous thromboembolism ,medicine.drug - Abstract
Commentary on: Schulman S, Kakkar AK, Goldhaber SZ, et al. Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation 2014;129:764–72.[OpenUrl][1][Abstract/FREE Full Text][2] Until recently, an initial course of parenteral anticoagulation followed by vitamin K antagonist (VKA) was the standard of care for the treatment of venous thromboembolism (VTE). In the past few years, direct oral anticoagulants (DOAC) have been found to be non-inferior to VKA.1–3 The RE-COVER study found dabigatran to be non-inferior to warfarin, with a reduced risk for clinically relevant bleeding.4 In order to confirm these findings, the RE-COVER II trial was performed and the results of both studies pooled. Almost identical to the RE-COVER study, RE-COVER II was a randomised, double-blind, double-dummy trial. It enrolled 2589 patients with acute, proximal deep vein thrombosis (DVT) or pulmonary embolism. Exclusion criteria included haemodynamic instability, thrombolytic therapy, recent unstable cardiovascular disease, high bleeding … [1]: {openurl}?query=rft.jtitle%253DCirculation%26rft_id%253Dinfo%253Adoi%252F10.1161%252FCIRCULATIONAHA.113.004450%26rft_id%253Dinfo%253Apmid%252F24344086%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=circulationaha&resid=129/7/764&atom=%2Febmed%2F19%2F5%2F180.atom
- Published
- 2014