Search

Background The main cause of death in RA patients is cardiovascular disease [1]. CD36 is a scavenger receptor has been postulated as a molecule involved in the atherogenic process [2,3]. A soluble fraction, sCD36 has been reported and has been proposed as a marker of atherosclerosis and other metabolic diseases [4,5], however, little is known of the pathways involved in these processes in RA. Objectives The objective of this study was to evaluate the levels of sCD36 and examine the association between clinical characteristics, disease activity and inflammatory markers in patients with RA. Methods The study groups were composed of 59 patients with RA (ACR/EULAR 2010) vs. 79 controls. sCD36, PCR, FR, Anti-CCP, insulin, TC, TG, HDL-C, VLDL-C, LDL-c were measured by ELISA. Index Disease Activity 28 (DAS-28) C-reactive protein (CRP) was calculated. VSG by Wintrobe method. cIMT using a Class B ultrasonography. Data were analyzed using descriptive statistics, Student t test, chi-square and ANOVA, as appropriate, with SPSS V.23 software. Results We found high levels of sCD36 in the control group (1861.10 ±6491.42±29.87 vs. 76.71, P Conclusions High levels of sCD36 were observed in serum from RA patients compared to a control group, as well as a relationship between sCD36 levels and Index Disease Activity 28 by pCr. It could be proposed to sCD36 as a marker of clinical activity of RA, however, more studies are needed to validate our findings and clarify the regulation and the role of sCD36 in RA. References Solomon, D.H., et al., Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation, 2003. 107(9): p. 1303–7. Freeman, M.W., Scavenger receptors in atherosclerosis. Curr Opin Hematol, 1997. 4(1): p. 41–7. Silverstein, R.L., Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36. Cleve Clin J Med, 2009. 76 Suppl 2: p. S27–30. Handberg, A., et al., Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Circulation, 2006. 114(11): p. 1169–76. Liani, R., et al., Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients. Free Radic Biol Med, 2012. 52(8): p. 1318–24. Disclosure of Interest None declared

Background Both sensorineural hearing impairment (SNHI) and conductuve hearing impairment (CHI) have been reported in about 50% of patients with rheumatoid arthritis (RA). Previous reports have related SNHI with advanced age, disease activity, rheumatoid nodules, erythrocyte sedimentation rate (ESR), serum IL-6 and serum matrix metalloproteases. These findings are suggestive that inflammatory activitiy in RA may be related with SNHI development. Notwhitstanding, scarce information about the impairment of tympano-ossicular complex compliance is reported. Objectives The aim of this study is to evaluate hearing impairment (HI) in patients with RA and examined the association between clinical characteristics, disease activity and inflammatory markers in Mexican patients with RA. Methods The study group was comprised of 41 patients with RA. Patients were examined using pure-tone audiometry and tympanometry. The Disease Activity Index 28 (DAS-28) by c reactive protein (cRP) was calculated. Data was analyzed using descriptive statistics, Student9s T test, chi-square and ANOVA, accordingly with SPSS V.18 software. Results We found 58.5% RA patients with SNHI. Of these, 9.7% had superficial, 9.7% mild and 2.4% profound SNHI. Patients with SNHI were older at diagnosis than patients without SNHI (44.5±8.7 vs 32.1±10.1, P 5.1) vs. 17.6% of A tympanogram group (p vs. 0.67±0.33 vs. 0.50±0.18, P =0.01. Conclusions The type and degree most prevalent of HI in our study group was superficial SNHL and was found to be related with aging and older age at diagnosis. These findings suggest that ear involvement in RA, may exacerbate aging related HI Increasing disease activity. Levels of inflammatory markers and the presence of anti-CCP antibodies are related with worse HI in RA. Disclosure of Interest None declared

Background The main causes of death in Rheumatoid Arthritis (RA) are cardiovascular events related to early atherosclerosis, myocardial infarction and congestive heart failure. The risk for cardiovascular disease it it not completely explained by the traditionally accepted cardiovascular risk factors. Inflammatory pathways of RA might be involved in the pathogenesis of subclinical atherosclerosis. Objectives To evaluate the relationship of anti-CCP antibody titers, serum IL-6, TNFa and high sensitivity c-Reactive Protein with increased carotid intima-media thickness (cIMT) in patients with RA without cardiovascular risk factors. Methods Sixty patients with RA, 27 anti-CCP positive and 33 anti-CCP negative, and 62 controls (HC) matched by age and gender. All groups were assessed for comorbidities, demographics, clinical evaluations, and cardiovascular risk calculated by atherogenic index of plasma (AIP). The cIMT was performed by high-resolution B-mode ultrasound by a single operator. Serum titers of anti-CCP, hs-cRP, levels of TNFα and IL-6 were measured by ELISA. Results The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative patients (p Conclusions High levels of anti-CCP and hs-cRP are useful markers of an increased cIMT and cardiovascular risk supporting a clinical role of the preventive measurement of cIMT in RA Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5947