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ObjectiveTo examine risk factors for cardiac-related PASC in community-dwelling adults after acute coronavirus disease 2019 (COVID-19) infection.MethodsWe performed a cross-sectional analysis among adults who tested positive for COVID-19. Outcomes were self-reported cardiac-related PASC. We conducted stepwise multivariable logistic regression to assess association between the risk factors (existing cardiovascular disease, pre-existing conditions, days since positive test, COVID hospitalization, age, sex, education, income) and cardiac-related PASC.ResultsAmong a sample of 442 adults, mean(±SD) age was 45.4 (16.2) years, 71% female, 13% Black; 46% reported pre-existing conditions; 23% had cardiovascular (CV) risk factors; and 4% had cardiovascular diseases (CVD). The prevalence of persistent cardiac-related symptoms and newly diagnosed cardiac conditions was 43% and 27%, respectively. The odds for cardiac-related PASC were 2.01 (95%CI: 1.27-3.17) higher in persons with underlying CV risk factors/CVD than in those without. The odds for cardiac-related PASC were higher among persons with underlying pre-existing conditions (adjusted odds ratio aOR: 2.00, 95% CI:1.28-3.10) and among those who were hospitalized (aOR: 3.03, 95%CI:1.58-5.83).ConclusionsMore than a third of persons with COVID-19 reported cardiac-related PASC symptoms. Risk factors for cardiac-related PASC symptoms include underlying CV risk factors/CVD, pre-existing conditions, increasing age, and COVID-19 hospitalization. COVID-19 may play an important role in worsening the prognosis of existing CV risk factors and increasing risk of complications.Key MessagesWhat is already known on this topicInfection with SARS-CoV-2 virus may lead to persistent cardiac symptoms indicative of cardiac injury. COVID-19 may play an important role in worsening the prognosis of existing CVD and pre-existing conditions.What this study addsLittle is known about characterization of cardiac-related Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and recovery in community-dwelling adults. Hence, this study provides further evidence on the burden of possible cardiac-related PASC symptoms and diagnosed cardiac conditions. The findings also suggest that underlying CVD, pre-existing conditions, older age, and COVID-19 hospitalization, may be risk factors for persistent cardiac-related PASC symptoms.How this study might affect research, practice or policyThese results underscore urgent needs for coordinated efforts directed at resource allocation and optimization of primary care for persons with cardiac PASC and for prevention of resulting CV events and complications