1. CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
- Author
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Gutman G, Morad T, Peleg B, Peretz C, Bar-Am A, Safra T, and Grisaru D
- Subjects
- Adult, Case-Control Studies, Female, Genotype, Humans, Israel, Polymerase Chain Reaction, Prognosis, Cytochrome P-450 CYP1A1 genetics, Cytochrome P-450 CYP2D6 genetics, Jews genetics, Polymorphism, Genetic genetics, Uterine Cervical Neoplasms genetics
- Abstract
Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer., Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method., Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003)., Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.
- Published
- 2009
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