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Your search keyword '"Martínez-Estupiñán, L."' showing total 8 results
Start Over Author "Martínez-Estupiñán, L." Publisher bmj
8 results on '"Martínez-Estupiñán, L."'

1. AB0253 To What Extent is Foot Pain Attributable to Disease Activity in RA Patients?

Author

Hernandez-Flόrez, D., primary, González-Fernández, M.L., additional, Valor, L., additional, Morales Lozano, M.R., additional, Martínez, J., additional, del Río, T., additional, Nieto, J.C., additional, Janta, I., additional, Lopez Longo, F.J., additional, González, C., additional, Monteagudo, I., additional, Martínez-Estupiñán, L., additional, Garrido, J., additional, Naredo, E., additional, and Carreño, L., additional

Published
2015
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2. SAT0615 Comparison Between Full and Tapered Dosages of Biologic Therapies in Psoriatic Arthritis Patients: Clinical and Ultrasound Assessment

Author

Janta, I., primary, Martínez-Estupiñán, L., additional, Valor, L., additional, Montoro, M., additional, Baniandres Rodriguez, O., additional, Hernández Aragüés, I., additional, Bello Vega, N., additional, Hernández-Flόrez, D., additional, Hinojosa Davila, M., additional, Martínez-Barrio, J., additional, Nieto-González, J.C., additional, Ovalles-Bonilla, J.G., additional, González, C.M., additional, Lόpez-Longo, F.J., additional, Monteagudo, I., additional, Naredo, E., additional, and Carreño, L., additional

Published
2015
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3. THU0250 Predictive Value of Doppler Ultrasound-Detected Synovitis in Relation to Successful Tapering of Biology Therapy in Patients with Rheumatoid Arthritis

Author

Naredo, E., primary, Valor, L., additional, De la Torre, I., additional, Montoro, M., additional, Bello, N., additional, Martínez-Barrio, J., additional, Martínez-Estupiñán, L., additional, Nieto, J.C., additional, Ovalles-Bonilla, J.G., additional, Hernández, D., additional, González, C.M., additional, Lόpez-Longo, J., additional, Monteagudo, I., additional, and Carreño, L., additional

Published
2014
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4. AB0677 Late onset systemic lupus erythematosus: Is it actually a milder variant?

Author

Ovalles-Bonilla, J.G., primary, Martínez-Barrio, J., additional, Lόpez-Longo, F., additional, de la Torre, I., additional, González, C., additional, Valor, L., additional, Montoro-Άlvarez, M., additional, Aramburu, F., additional, Marín, C., additional, Martínez-Estupiñán, L., additional, Nieto, J., additional, Hinojosa, M., additional, Bello, N., additional, Monteagudo, I., additional, and Carreño, L., additional

Published
2013
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5. SAT0441 Juvenile Onset Systemic Sclerosis: Clinical and Serological Features, and Mortality in Comparison with Adult Onset Disease

Author

Ovalles-Bonilla, J. G., primary, López-Longo, F. J., additional, Monteagudo, I., additional, Naredo, E., additional, Gonzalez, C. M., additional, de la Torre, I., additional, Montoro, M., additional, Martínez-Estupiñán, L. P., additional, Nieto, J. C., additional, Martínez-Barrio, J., additional, Hinojosa, M., additional, Bello, N., additional, Serrano, B., additional, Mata, C., additional, and Carreño, L., additional

Published
2013
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6. FRI0260 Survival, causes of death and mortality risk factors in systemic sclerosis

Author

Ovalles-Bonilla, J.G., primary, Martínez-Barrio, J., additional, Lόpez-Longo, F., additional, de la Torre, I., additional, González, C., additional, Valor, L., additional, Montoro-Άlvarez, M., additional, Aramburu, F., additional, Marín, C., additional, Martínez-Estupiñán, L., additional, Nieto, J., additional, Hinojosa, M., additional, Bello, N., additional, Monteagudo, I., additional, and Carreño, L., additional

Published
2013
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7. AB0678 Artrhitic patterns in systemic lupus erythematosus

Author

Ovalles-Bonilla, J.G., primary, Martínez-Barrio, J., additional, Lόpez-Longo, F., additional, de la Torre, I., additional, González, C., additional, Valor, L., additional, Montoro-Άlvarez, M., additional, Aramburu, F., additional, Marín, C., additional, Martínez-Estupiñán, L., additional, Nieto, J., additional, Hinojosa, M., additional, Bello, N., additional, Monteagudo, I., additional, and Carreño, L., additional

Published
2013
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8. Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis.

Author

Carmona FD, Gutala R, Simeón CP, Carreira P, Ortego-Centeno N, Vicente-Rabaneda E, García-Hernández FJ, García de la Peña P, Fernández-Castro M, Martínez-Estupiñán L, Egurbide MV, Tsao BP, Gourh P, Agarwal SK, Assassi S, Mayes MD, Arnett FC, Tan FK, and Martín J

Subjects
Antibodies, Antinuclear biosynthesis, Autoimmune Diseases immunology, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Scleroderma, Systemic immunology, Antibodies, Antinuclear blood, Autoimmune Diseases genetics, Interferon Regulatory Factor-7 genetics, Scleroderma, Systemic genetics
Abstract

Objective: Systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are related chronic autoimmune diseases of complex aetiology in which the interferon (IFN) pathway plays a key role. Recent studies have reported an association between IRF7 and SLE which confers a risk to autoantibody production. A study was undertaken to investigate whether the IRF7 genomic region is also involved in susceptibility to SSc and the main clinical features., Methods: Two case-control sets of Caucasian origin from the USA and Spain, comprising a total of 2316 cases of SSc and 2347 healthy controls, were included in the study. Five single nucleotide polymorphisms (SNPs) in the PHRF1-IRF7-CDHR5 locus were genotyped using TaqMan allelic discrimination technology. A meta-analysis was performed to test the overall effect of these genetic variants on SSc., Results: Four out of five analysed SNPs were significantly associated with the presence of anticentromere autoantibodies (ACA) in the patients with SSc in the combined analysis (rs1131665: p(FDR)=6.14 × 10(-4), OR=0.78; rs4963128: p(FDR)=6.14 × 10(-4), OR=0.79; rs702966: p(FDR)=3.83 × 10(-3), OR=0.82; and rs2246614: p(FDR)=3.83 × 10(-3), OR=0.83). Significant p values were also obtained when the disease was tested globally; however, the statistical significance was lost when the ACA-positive patients were excluded from the study, suggesting that these associations rely on ACA positivity. Conditional logistic regression and allelic combination analyses suggested that the functional IRF7 SNP rs1131665 is the most likely causal variant., Conclusions: The results show that variation in the IRF7 genomic region is associated with the presence of ACA in patients with SSc, supporting other evidence that this locus represents a common risk factor for autoantibody production in autoimmune diseases.

Published
2012
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