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11 results on '"Kaniewski, Nadine"'

1. Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe

Author

Pascal Guénel, Franco Merletti, Linda Kaerlev, Giuseppe Gorini, Mikael Eriksson, Cornelia Baumgardt-Elms, Lennart Hardell, Elsebeth Lynge, Sara Villeneuve, Laurent Orsi, Svend Sabroe, Diane Cyr, Wolfgang Ahrens, María Morales-Suárez-Varela, Joelle Fevotte, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Department of Epidemiology, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Epidemiology and Public Health, Environmental and Occupational Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Unit of Public Health and Environmental Care, Université de Valence, Centro de Investigation Biomedica en Red (CB06/02/045), Institute Carlo III, Research Foundation, University Hospital Dr. Peset, Bremen Institute for Prevention Research and Social Medicine, Hamburg Cancer Registry, Center for National Clinical Databases South, Odense University Hospital, Department of Oncology, Lund University Hospital, Örebro University Hospital [Örebro, Sweden], Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité (INRETS), Kaniewski, Nadine, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), and Universitat de València (UV)

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Breast Neoplasms, Endocrine Disruptors, Article, Breast Neoplasms, Male, Occupational medicine, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Breast cancer, Occupational Exposure, Internal medicine, Environmental health, Epidemiology, medicine, Humans, Industry, Occupations, skin and connective tissue diseases, Aged, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Cancer, Middle Aged, medicine.disease, 030210 environmental & occupational health, 3. Good health, Occupational Exposures, Europe, Occupational Diseases, Endocrinology, Endocrine disruptor, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, 030220 oncology & carcinogenesis, Male breast cancer, Educational Status, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Breast disease, Epidemiologic Methods, business
Abstract

Objectives Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. Methods Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement. Results Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens. Conclusion These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer.

Published
2010

2. Do different measures of early life socioeconomic circumstances predict adult mortality? Evidence from the British Whitehall II and French GAZEL studies

Author

Aline Dugravot, Mika Kivimäki, Jane E. Ferrie, Marie Zins, Archana Singh-Manoux, Marcel Goldberg, Silvia Stringhini, Martin J. Shipley, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Kaniewski, Nadine, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

Subjects
Male, Gerontology, Epidemiology, 030204 cardiovascular system & hematology, France/epidemiology, MESH: Proportional Hazards Models, MESH: Cause of Death, Cohort Studies, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Neoplasms, Cause of Death, Medicine, MESH: Neoplasms, 030212 general & internal medicine, MESH: Cohort Studies, Cardiovascular Diseases/mortality, Cause of death, MESH: Aged, MESH: Middle Aged, MESH: Risk, United Kingdom/epidemiology, MESH: Follow-Up Studies, Middle Aged, Early life, 3. Good health, Cardiovascular Diseases, MESH: Great Britain, Female, France, Neoplasms/mortality, Socioeconomic Indicator, Cohort study, Adult, Risk, Social class, Article, MESH: Social Class, 03 medical and health sciences, Humans, Occupations, Socioeconomic status, Aged, Proportional Hazards Models, Cardiovascular mortality, MESH: Occupations, MESH: Humans, Proportional hazards model, business.industry, Public Health, Environmental and Occupational Health, MESH: Cardiovascular Diseases, MESH: Adult, United Kingdom, MESH: Male, MESH: France, Social Class, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Follow-Up Studies, Demography
Abstract

International audience; BACKGROUND: Father's occupational position, education and height have all been used to examine the effects of adverse early life socioeconomic circumstances on health, but it remains unknown whether they predict mortality equally well. METHODS: We used pooled data on 18,393 men and 7060 women from the Whitehall II and GAZEL cohorts to examine associations between early life socioeconomic circumstances and all-cause and cause-specific mortality. RESULTS: During the 20-y follow-up period, 1487 participants died. Education had a monotonic association with all mortality outcomes; the age, sex and cohort-adjusted HR for the lowest versus the highest educational group was 1.45 (95% CI 1.24 to 1.69) for all-cause mortality. There was evidence of a U-shaped association between height and all-cause, cancer and cardiovascular mortality robust to adjustment for the other indicators (HR 1.41, 95% CI 1.03 to 1.93 for those shorter than average and HR 1.36, 95% CI 0.98 to 1.88 for those taller than average for cardiovascular mortality). Greater all-cause and cancer mortality was observed in participants whose father's occupational position was manual rather than non-manual (HR 1.11, 95% CI 1.00 to 1.23 for all-cause mortality), but the risks were attenuated after adjusting for education and height. CONCLUSIONS: The association between early life socioeconomic circumstances and mortality depends on the socioeconomic indicator used and the cause of death examined. Height is not a straightforward measure of early life socioeconomic circumstances as taller people do not have a health advantage for all mortality outcomes.

Published
2010

3. Work disability following major organisational change: the Whitehall II study

Author

Mika Kivimäki, Archana Singh-Manoux, Tasnime N. Akbaraly, Marianna Virtanen, Martin J. Shipley, Jussi Vahtera, David Gimeno, Jane E. Ferrie, Michael Marmot, Finnish Institute of Occupational Health, Department of Epidemiology and Public Health, University College of London [London] (UCL), Faculty of Behavioral Sciences, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Division of Environmental and Occupational Health Sciences, The University of Texas Health Science Center at Houston (UTHealth), The Institute for Work and Health, Department of Public Health, University of Turku-Finnish Institute of Occupational Health-Turku University Hospital (TYKS), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Turku University Hospital (TYKS)-University of Turku-Finnish Institute of Occupational Health, and Kaniewski, Nadine

Subjects
Adult, Employment, Male, Gerontology, medicine.medical_specialty, Epidemiology, Article, Cohort Studies, Occupational medicine, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Work Schedule Tolerance, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Workplace, Finland, Pension, Public Sector, business.industry, Public health, Public sector, Administrative Personnel, Public Health, Environmental and Occupational Health, Middle Aged, Private sector, 030210 environmental & occupational health, Mental health, Organizational Innovation, Occupational Diseases, Work (electrical), [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 8. Economic growth, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Stress, Psychological, Follow-Up Studies, Cohort study
Abstract

International audience; BACKGROUND: Privatisation and private sector practices have been increasingly applied to the public sector in many industrialised countries. Over the same period, long-term work disability has risen substantially. We examined whether a major organisational change--the transfer of public sector work to executive agencies run on private sector lines--was associated with an increased risk of work disability. METHODS: The study uses self-reported data from the prospective Whitehall II cohort study. Associations between transfer to an executive agency assessed at baseline (1991-1994) and work disability ascertained over a period of approximately 8 years at three follow-up surveys (1995-1996, 1997-1999 and 2001) were examined using Cox proportional hazard models. RESULTS: In age- and sex-adjusted models, risk of work disability was higher among the 1263 employees who were transferred to an executive agency (HR 1.90, 95% CI 1.46 to 2.48) compared with the 3419 employees whose job was not transferred. These findings were robust to additional adjustment for physical and mental health and health behaviours at baseline. CONCLUSIONS: Increased work disability was observed among employees exposed to the transfer of public sector work to executive agencies run on private sector lines. This may highlight an unintentional cost for employees, employers and society.

Published
2010

4. Investigating the spatial variability in incidence of coronary heart disease in the Gazel Cohort: the impact of area socioeconomic position and mediating role of risk factors

Author

Romain Silhol, Marie Zins, Basile Chaix, Pierre Chauvin, Kaniewski, Nadine, ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

Subjects
Male, Gerontology, Epidemiology, 030204 cardiovascular system & hematology, Overweight, Cohort Studies, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, MESH: Demography, Surveys and Questionnaires, Health Status Indicators, MESH: Incidence, 030212 general & internal medicine, MESH: Cohort Studies, MESH: Middle Aged, Incidence, Incidence (epidemiology), MESH: Life Style, Middle Aged, Cardiovascular Diseases, Social Conditions, Epidemiological Monitoring, Cohort, Female, France, medicine.symptom, MESH: Environmental Monitoring, Environmental Monitoring, Cohort study, Adult, MESH: Socioeconomic Factors, Article, MESH: Multivariate Analysis, MESH: Social Class, 03 medical and health sciences, MESH: Health Status Indicators, Environmental health, MESH: Cities, medicine, Humans, MESH: Social Conditions, cardiovascular diseases, Cities, Occupations, Risk factor, Life Style, Socioeconomic status, Demography, MESH: Occupations, MESH: Humans, business.industry, Proportional hazards model, MESH: Questionnaires, Public Health, Environmental and Occupational Health, MESH: Cardiovascular Diseases, MESH: Adult, medicine.disease, Obesity, MESH: Male, MESH: France, Social Class, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract

International audience; STUDY OBJECTIVE: The aim of the study was to improve understanding of the relationships between contextual socioeconomic characteristics and coronary heart disease (CHD) incidence in France. Several authors have suggested that CHD risk factors (diabetes, hypertension, cholesterol, overweight, tobacco consumption) may partly mediate associations between socioeconomic environmental variables and CHD. Studies have assessed the overall mediating role of CHD risk factors, but have never investigated the specific mediating role of each risk factor, not allowing their specific contribution to the area socioeconomic position-CHD association to be disentangled. DESIGN: After assessing geographical variations in CHD incidence and socioeconomic environmental effects on CHD using a multilevel Cox model, the extent to which this contextual effect was mediated by each of the CHD risk factors was assessed. PARTICIPANTS: Data of the French GAZEL cohort (n=19,808) were used. MAIN RESULTS: After adjustment for several individual socioeconomic indicators, it was found, in men from highly urbanised environments, that CHD incidence increased with decreasing socioeconomic position of the residential environment. After individual-level adjustment, a higher risk of obesity, smoking and cholesterol was observed in the most deprived residential environments. When risk factors were introduced into the model, a modest decrease was observed in the magnitude of the association between the socioeconomic contextual variable and CHD. Risk factors that contributed most to the decrease of the association were smoking and cholesterol. CONCLUSIONS: Classic risk factors, although some of them more than others, mediated a modest part of the association between area socioeconomic position and CHD.

Published
2009

5. All-cause and diagnosis-specific sickness absence as a predictor of sustained suboptimal health: a 14-year follow-up in the GAZEL cohort

Author

Jane E. Ferrie, Jussi Vahtera, Maria Melchior, Kristina Alexanderson, Hugo Westerlund, Mika Kivimäki, Marie Zins, Marcel Goldberg, Archana Singh-Manoux, Jenny Head, Kaniewski, Nadine, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Department of Public Health, Turku University Hospital (TYKS)-University of Turku, Stress Research Institute, Stockholm University, Department of Epidemiology and Public Health, University College of London [London] (UCL), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département santé travail (DST-InVS), Institut de Veille Sanitaire (INVS), Section of Personal Injury Prevention, Karolinska Institutet [Stockholm], Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and University of Turku-Turku University Hospital (TYKS)

Subjects
Adult, Male, medicine.medical_specialty, longitudinal, Epidemiology, Health Status, Disease, Logistic regression, Article, self-rated health, Sickness absence, Cohort Studies, Diagnostic Self Evaluation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Absenteeism, Diagnosis, medicine, Humans, occupational, 030212 general & internal medicine, Psychiatry, Self-rated health, business.industry, Public health, Public Health, Environmental and Occupational Health, Middle Aged, 030210 environmental & occupational health, multi-level, 3. Good health, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, Sick leave, Regression Analysis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Sick Leave, business, Follow-Up Studies, Cohort study
Abstract

International audience; background: Previous studies show that sickness absence predicts health, but it is unclear whether this association is persistent over time and whether specific diseases underlie long-term associations. The aim of this study was to investigate overall and diagnosis-specific sickness absences as predictors of sustained suboptimal health. METHODS: Prospective occupational cohort study of 15 320 employees (73% men) aged 37-51. Sickness absence records in 1990-1992, including 13 diagnostic categories, were examined in relation to self-rated health measured annually for the years 1993-2006. RESULTS: 3385 employees (22%) had >30 days of sickness absence and 5564 (36%) 1-30 days during the 3-year exposure window. Repeated-measures logistic regression analysis adjusted for age, sex, occupational status and chronic diseases show that employees with >30 absence days, compared with those with no absences, had 2.14 (95% CI 2.00 to 2.29) times higher odds for suboptimal health over the 14 years of follow-up. Retirement did not dilute this association. Nine sickness absence diagnostic categories, such as diseases of the nervous, circulatory, metabolic, musculoskeletal, sensory and gastrointestinal systems, cancer, mental disorders and external causes, independently predicted increased risk of sustained suboptimal health. CONCLUSIONS: There is a remarkably persistent association between sickness absence and future long-term self-rated health status for the majority of diagnostic categories for sickness absence. This suggests that the association between sickness absence and health is ubiquitous and not driven by a limited number of rare and severe diseases.

Published
2009

6. Socioeconomic position and cognitive decline using data from two waves: what is the role of the wave 1 cognitive measure?

Author

Aline Dugravot, Jussi Vahtera, Mika Kivimäki, Alice Guéguen, Archana Singh-Manoux, Martin J. Shipley, Michael Marmot, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Epidemiology and Public Health, University College of London [London] (UCL), Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Kaniewski, Nadine, and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, Gerontology, Aging, medicine.medical_specialty, Epidemiology, Social class, behavioral disciplines and activities, Article, 050105 experimental psychology, 03 medical and health sciences, Cognition, 0302 clinical medicine, Bias, medicine, Humans, 0501 psychology and cognitive sciences, 030212 general & internal medicine, Cognitive decline, skin and connective tissue diseases, Baseline (configuration management), Socioeconomic status, Analysis of covariance, Analysis of Variance, business.industry, Public health, 05 social sciences, Cognitive disorder, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Social Class, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, sense organs, Cognition Disorders, business, Demography
Abstract

International audience; BACKGROUND: Analysis of change in health status using data from two waves can be examined either adjusted or unadjusted for baseline health status. The effect of socioeconomic position (SEP) on cognitive change was assessed using both these strategies and the implications of the analyses are discussed. METHODS: Data from 1261 men and 483 women of the Whitehall II cohort study, aged 50-55 years at wave 1, were used. Cognition was assessed at both waves using a test of verbal memory, and two tests of verbal fluency. Analysis of variance (ANOVA) was used to estimate the effect of SEP on change score and analysis of covariance (ANCOVA) was used to estimate this effect adjusted for the baseline cognitive score. The ANCOVA estimates were corrected for bias due to measurement error (estimated based on 3-month test-retest). Finally, ANCOVA estimates were examined for increasing levels of measurement error. RESULTS: The results of the ANOVA suggest no effect of SEP on cognitive decline. In contrast, the ANCOVA suggests significantly greater cognitive decline in the lower SEP groups. However, the ANCOVA estimates for the effect of wave 1 cognition show evidence for regression to the mean due to the presence of measurement error. The corrected ANCOVA estimates show no association between SEP and cognitive decline. CONCLUSIONS: Results from analysis of change using two waves of observational data, when adjusted for baseline, should be interpreted with caution.

Published
2009

7. Social inequalities in mortality by cause among men and women in France

Author

Saurel-Cubizolles, Marie-Josèphe, Chastang, Jean-François, Menvielle, Gwenn, Leclerc, Anette, Luce, Daniele, Group, Edisc, Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé, CCTIRS, Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Kaniewski, Nadine

Subjects
Adult, Male, Gerontology, medicine.medical_specialty, Epidemiology, Poison control, Article, Occupational safety and health, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Cause of Death, Neoplasms, Injury prevention, medicine, Humans, Social inequality, 030212 general & internal medicine, Social determinants of health, Mortality, Aged, 030505 public health, business.industry, Public health, Relative index of inequality, Public Health, Environmental and Occupational Health, Health Status Disparities, Middle Aged, 3. Good health, Social Class, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cardiovascular Diseases, Educational Status, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, 0305 other medical science, business, Demography
Abstract

International audience; BACKGROUND: The aim of this study was to compare inequalities in mortality (all causes and by cause) by occupational group and educational level between men and women living in France in the 1990s. METHODS: Data were analysed from a permanent demographic sample currently including about one million people. The French Institute of Statistics (INSEE) follows the subjects and collects demographic, social and occupational information from the census schedules and vital status forms. Causes of death were obtained from the national file of the French Institute of Health and Medical Research (INSERM). A relative index of inequality (RII) was calculated to quantify inequalities as a function of educational level and occupational group. Overall all-cause mortality, mortality due to cancer, mortality due to cardiovascular disease and mortality due to external causes (accident, suicide, violence) were considered. RESULTS: Overall, social inequalities were found to be wider among men than among women, for all-cause mortality, cancer mortality and external-cause mortality. However, this trend was not observed for cardiovascular mortality, for which the social inequalities were greater for women than for men, particularly for mortality due to ischaemic cardiac diseases. CONCLUSIONS: This study provides evidence for persistent social inequalities in mortality in France, in both men and women. These findings highlight the need for greater attention to social determinants of health. The reduction of cardiovascular disease mortality in low educational level groups should be treated as a major public health priority.

Published
2009

8. Household exposure to pesticides and risk of childhood acute leukaemia

Author

Brigitte Nelken, Florence Menegaux, André Baruchel, Brigitte Lescoeur, Yves Bertrand, Denis Hémon, Danièle Sommelet, Guy Leverger, Jacqueline Clavel, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie pédiatrique, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service pédiatrique d'hématologie, Hospices Civils de Lyon (HCL)-Hôpital Debrousse, Hospices Civils de Lyon (HCL), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service pédiatrique d'hématologie-oncologie, Hôpital Jeanne de Flandre [Lille], Service d'Hématologie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Kaniewski, Nadine

Subjects
Male, Insecticides, Pediculosis, Ethnic origin, 010501 environmental sciences, MESH: Epidemiologic Methods, 01 natural sciences, MESH: Pregnancy, 0302 clinical medicine, Pregnancy, MESH: Child, Epidemiology, MESH: Maternal Exposure, Child, Acute leukemia, Leukemia, MESH: Infant, Newborn, Environmental exposure, Lice Infestations, MESH: Prena, MESH: Infant, 3. Good health, Maternal Exposure, Child, Preschool, Prenatal Exposure Delayed Effects, 030220 oncology & carcinogenesis, Acute Disease, Paternal Exposure, MESH: Acute Disease, Female, Original Article, medicine.medical_specialty, Adolescent, MESH: Environmental Exposure, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Environmental health, MESH: Leukemia, medicine, Humans, MESH: Pesticides, Pesticides, Risk factor, 0105 earth and related environmental sciences, MESH: Adolescent, MESH: Paternal Exposure, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, MESH: Lice Infestations, Public Health, Environmental and Occupational Health, Infant, Environmental Exposure, Odds ratio, medicine.disease, MESH: Male, MESH: Insecticides, Surgery, Scalp Dermatoses, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Epidemiologic Methods, business, MESH: Female
Abstract

International audience; OBJECTIVES: To investigate the relation between childhood acute leukaemia and household exposure to pesticides. METHODS: The study included 280 incident cases of acute leukaemia and 288 controls frequency matched on gender, age, hospital, and ethnic origin. The data were obtained from standardised face to face interviews of the mothers with detailed questions on parental occupational history, home and garden insecticide use, and insecticidal treatment of pediculosis. Odds ratios were estimated using unconditional regression models including the stratification variables parental socioeconomic status and housing characteristics. RESULTS: Acute leukaemia was observed to be significantly associated with maternal home insecticide use during pregnancy (OR = 1.8, 95% CI 1.2 to 2.8) and during childhood (OR = 1.7, 95% CI 1.1 to 2.4), with garden insecticide use (OR = 2.4, 95% CI 1.3 to 4.3), and fungicide use (OR = 2.5, 95% CI 1.0 to 6.2) during childhood. Insecticidal shampoo treatment of pediculosis was also associated with childhood acute leukaemia (OR = 1.9, 95% CI 1.2 to 3.3). CONCLUSION: The results reported herein support the hypothesis that various types of insecticide exposure may be a risk factor for childhood acute leukaemia. The observed association with insecticidal shampoo treatment of pediculosis, which has never been investigated before, requires further study.

Published
2006

9. Routine testing to reduce late HIV diagnosis in France

Author

Cyrille Delpierre, Lise Cuzin, France Lert, Kaniewski, Nadine, Epidémiologie et Analyses en Santé Publique : risques, maladies chroniques et handicap (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM), Service Maladies infectieuses et tropicales [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Maladies Infectieuses et Tropicales, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

Subjects
Counseling, medicine.medical_specialty, Routine testing, Population, HIV Infections, Disease, 030312 virology, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), MESH: Early Diagnosis, medicine, Humans, Mass Screening, MESH: Mass Screening, 030212 general & internal medicine, education, ComputingMilieux_MISCELLANEOUS, Health policy, Mass screening, General Environmental Science, 0303 health sciences, education.field_of_study, MESH: Humans, business.industry, MESH: Counseling, Health Policy, Public health, Editorials, General Engineering, MESH: HIV Infections, General Medicine, medicine.disease, 3. Good health, MESH: France, Early Diagnosis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Family medicine, Immunology, General Earth and Planetary Sciences, MESH: Health Policy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Viral disease, business, Analysis
Abstract

Although around half the French population has had an HIV test, many people are still not diagnosed until the disease is advanced. Cyrille Delpierre and colleagues believe the answer is to expand routine testing

Published
2007

10. Work, a prognosis factor for upper extremity musculoskeletal disorders?

Author

Yves Roquelaure, Bradley A. Evanoff, Annette Leclerc, Jean-François Chastang, Alexis Descatha, Diane Cyr, Kaniewski, Nadine, Unité de pathologie professionnelle, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Poincaré, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Ergonomie et d'Épidémiologie en Santé au Travail (LEEST), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Institut de Veille Sanitaire (INVS), Division of General Medical Sciences, Washington University School of Medicine, and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

Subjects
Adult, Employment, Male, medicine.medical_specialty, Article, Upper Extremity, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, Musculoskeletal Diseases, ComputingMilieux_MISCELLANEOUS, 030222 orthopedics, business.industry, Work (physics), Public Health, Environmental and Occupational Health, Repetitive task, Middle Aged, 030210 environmental & occupational health, Occupational Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Physical therapy, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

Upper extremity musculoskeletal (UEMS) disorders are a significant problem in industrial countries.1 There is strong evidence for an association between biomechanical exposures and UEMS disorders.2–4 However, little is known about the occupational factors associated with recovery from these disorders.5–7 To determine if occupational factors were associated with outcome in workers with UEMS symptoms or disorders, we used data from a repetitive task survey performed in 1993–1994 and again in 1996–1997. The design has been described in earlier publications.8 9 Each worker had a standardised medical examination at baseline and again in 1996–1997. The self-administered questionnaire filled out at baseline included data on personal variables, a psychological variable, postures and biomechanical constraints at work (self-assessed, but checked with the …

Published
2009

11. Positive and negative affect and risk of coronary heart disease: Whitehall II prospective cohort study

Author

Archana Singh-Manoux, Roberto De Vogli, Michael Marmot, Mika Kivimäki, Hermann Nabi, Department of Epidemiology and Public Health, University College of London [London] (UCL), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Kaniewski, Nadine, and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, Gerontology, medicine.medical_specialty, Coronary Disease, 030204 cardiovascular system & hematology, MESH: Epidemiologic Methods, Angina, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Internal medicine, London, mental disorders, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Sex Distribution, Risk factor, Prospective cohort study, MESH: Age Distribution, General Environmental Science, 2. Zero hunger, MESH: Humans, MESH: Middle Aged, Framingham Risk Score, Proportional hazards model, business.industry, Research, MESH: Sex Distribution, Hazard ratio, General Engineering, MESH: Adult, General Medicine, Middle Aged, MESH: London, Epidemiologic Methods, Female, medicine.disease, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, General Earth and Planetary Sciences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Coronary Disease, business, MESH: Female, Cohort study
Abstract

International audience; OBJECTIVE: To examine the associations between positive and negative affect and subsequent coronary heart disease events independently of established risk factors. DESIGN: Prospective cohort study with follow-up over 12 years. SETTING: 20 civil service departments originally located in London. PARTICIPANTS: 10,308 civil servants aged 35-55 years at entry into Whitehall II study in 1985. MAIN OUTCOME MEASURES: Fatal coronary heart disease, clinically verified incident non-fatal myocardial infarction, and definite angina (n=619, mean follow-up 12.5 years). RESULTS: In Cox regression analysis adjusted for age, sex, ethnicity, and socioeconomic position, positive affect (hazard ratio=1.01, 95% confidence interval 0.82 to 1.24) and the balance between positive and negative affect, referred to as the affect balance score (hazard ratio=0.89, 0.73 to 1.09), were not associated with coronary heart disease. Further adjustment for behaviour related risk factors (smoking, alcohol consumption, daily fruit and vegetable intake, exercise, body mass index), biological risk factors (hypertension, blood cholesterol, diabetes), and psychological stress at work did not change these results. However, participants in the highest third of negative affect had an increased incidence of coronary events (hazard ratio=1.32, 1.09 to 1.60), and this association remained unchanged after adjustment for multiple confounders. CONCLUSIONS: Positive affect and affect balance did not seem to be predictive of future coronary heart disease in men and women who were free of diagnosed coronary heart disease at recruitment to the study. A weak positive association between negative affect and coronary heart disease was found and needs to be confirmed in further studies.

Published
2008

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