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Objective To study the correlation between renal function (GFR and mAlb) and arterial elasticity indices (baPWV, cfPWV, C1, C2 and ABI) in hypertensive patients. Methods One hundred and forty subjects (38 normotensive subjects (NS group) and 102 essential hypertensive patients (EH group)) were enrolled. baPWV, cfPWV and ABI were measured by BP-203RPE II (VP-1000) device, and C1, C2 were measured by CVProfilor DO-2020 device. Glomerular filtration rate (GFR) and microalbuminuria (mAlb) were used as the indexes of renal function. Results (1) baPWV, cfPWV and ABI were significantly higher in EH group than that in NS group. C1, C2 and GFR were significantly lower in EH group than that in NS group. (2) baPWV and cfPWV increased progressively with decreasing GFR (p

Objective To investigate the association between BMI and the incidence of ischaemic stroke in essential hypertensive (EH) patients. Methods A total of 2158 EH patients were divided into EH without ischaemic stroke group and EH with ischaemic stroke group. Four BMI quartiles were defined based on BMI level (The first quartile: BMI ≤22.68 kg/m 2 , n=540; The second quartile: BMI 22.69–24.82 kg/m 2 , n=538; The third quartile: BMI 24.83–26.84 kg/m 2 , n=541; The fourth quartile: BMI ≥26.85 kg/m 2 , n=539). The incidence of ischaemic stroke in four BMI levels was evaluated by multivariable logistic regression analyses. Results (1) The average BMI in EH with ischaemic stroke group is lower than that in EH without ischaemic stroke group (24.36±3.21 vs 25.15±3.31kg/m 2 , p 2 increase of BMI. (3) Compared with the lowest BMI group, the adjusted OR (aOR) for ischaemic stroke in the highest BMI group was significantly lower (aOR: 0.800, 95% CI: 0.730 to 0.875, p Conclusion Lower BMI was associated with increased incidence of ischaemic stroke in EH patients.

Objective To study the correlation between pulse wave velocity (PWV) with C1, C2, ABI in hypertensive patients. Methods One hundred and forty subjects (38 normotensive subjects (NS group) and 102 essential hypertensive patients (EH group)) were enrolled. Different segments of PWV (baPWV, cfPWV, cbPWV, faPWV) and ABI were measured by BP-203RPE II (VP-1000) device. C1, C2 were measured by CVProfilor DO-2020 device. The correlation between cfPWV and other indexes of arterial elasticity function was analysed. Results (1) Each segment of PWV and ABI were significantly higher in EH group than that in NS group (p Conclusions baPWV is a simple and sensitive method of measuring PWV. Age, SBP and DBP are risk factors of the elevated stiffness in both central and peripheral arteries.

Aims To compare the effectiveness of transient prehypertensive treatment with losartan vs amlodipine in spontaneously hypertensive rats (SHR) on long-term blood pressure and cardiac protection Main methods SHR were prehypertensively (weeks 4–10 of age) treated with losartan (SHR-Los: 20 mg/kg/day), amlodipine (SHR-Aml: 10 mg/kg/day) or saline (n=24 each group). Rats were followed up until week 46. Systolic blood pressure (SBP) was measured by tail-cuff method. Cardiac parameters including Left ventricular (LV) mass index (LVMI), collagen volume fraction (CVF) and LV function were assessed by histomorphometry and echocardiography. Plasma and myocardium Angiotensin II (Ang II) and aldosterone (Aldo) were measured by radioimmunoassay. Cardiac angiotensin II type 1 and type 2 receptor (AT1R and AT2R) protein were determined by immunoblotting and brain natriuretic peptide (BNP) mRNA was semi-quantified by reverse transcription-PCR (RT-PCR). Key findings The SBP in SHR-Los was reduced until age 46 weeks, but returned to untreated SHR levels in SHR-Aml from 30 weeks onwards. Compared to untreated SHR, the LVMI and CVF in SHR-Los were markedly decreased until week 46, and the LV ejection fraction (LVEF) (SHR-Los vs SHR: 83.1±2.3% vs 79.5±1.9%, p

Objective To investigate the relationship between red cell distribution width (RDW) level and risk of complication in acute myocardial infarction (AMI) patients; to compare the correlation of RDW with NT-proBNP, cTnI and hs-CRP. Methods From January 2006 to December 2009, 200 consecutive AMI patients admitted in cardiology department of affiliated hospital of putian university were enrolled. Patients were classified into complication group (n=145) or complication-free group (n=55) according to the presence or absence of new-onset symptomatic heart failure, arrhythmia or cardiac shock. Patients were divided into quartiles based on RDW value (≤12.8%, 12.9%–13.8%, 13.9%–14.7%, ≥14.8%, n=50 in each quartile), and OR of incident complication was calculated by using logistic regression. Correlation of RDW with NT-proBNP, cTnI and hs-CRP was compared by spearman rank correlation analysis. Results RDW levels in complication group was significantly higher than that in Complication-free group (14.5±0.97 % vs 12.9±0.85%, p hs-CRP (rs=0.31, 0.29 and 0.21 respectively, all p Conclusion Higher RDW is closely associated with increased risk of AMI complication and elevated plasma NT-proBNP and cTnI level.