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We describe the case of a 55-year-old woman presenting with a recent onset of mild cough and no other specific cardiovascular symptoms, and with a normal examination. Salient past medical history included BRAF-positive melanoma resected from the small bowel with abdominal, left inguinal and pulmonary metastases, 2 years prior. Following immunotherapy with combined dabrafenib and trametinib for 6 months and subsequently, ipilimumab, complete remission was achieved. The only other significant history was of type 2 diabetes mellitus with metformin therapy. Plain radiographs of the chest were unremarkable, and a subsequent fluorodeoxyglucose positron emission tomography (FDG PET) demonstrated focal uptake in the anterior left ventricle (figure 1). Transoesophageal echocardiography (TOE) demonstrated a large, voluminous intracavitary left ventricular mass (45×25 mm) attached to the mid anterior wall without evidence of obstruction (figure 2, video 1). Cardiac MRI confirmed a mass with increased signal intensity on T1-weighted imaging suggestive of metastatic melanoma in …

A 55-year-old woman presented with chest pain following a high-speed motor vehicle accident. ECG revealed sinus rhythm with anterior lead ST depression. High-sensitivity troponin increased from baseline 58 to peak of 477 ng/L (normal