1. Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C
- Author
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Francesco Vizzutti, Massimo Pinzani, Jaime Bosch, E. Lorefice, A. Petrarca, Fabio Marra, Cristina Stasi, Giampaolo Corti, Roberto Giulio Romanelli, Juan G. Abraldes, Giacomo Laffi, Stefano Milani, Umberto Arena, S. Moscarella, and Universitat de Barcelona
- Subjects
Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Cirrhosis ,Biopsy ,Chronic liver disease ,Severity of Illness Index ,Gastroenterology ,Fetge ,Fibrosis ,Internal medicine ,medicine ,Humans ,Ultrasonography, Interventional ,Aged ,Hepatitis ,medicine.diagnostic_test ,Ultrasonic imaging ,business.industry ,Hepatitis C ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Elasticity ,Fatty Liver ,Diagnòstic per la imatge ,Liver ,Ecografia ,Liver biopsy ,Disease Progression ,Elasticity Imaging Techniques ,Diagnostic imaging ,Female ,Steatosis ,business ,Transient elastography - Abstract
Background: Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease. Aim: To assess the value of TE for predicting the stage of fibrosis. Methods: Liver biopsy and TE were performed in 150 consecutive patients with chronic hepatitis C-related hepatitis (92 men and 58 women, age 50.6 (SD 12.5) years on the same day. Necro-inflammatory activity and the degree of steatosis at biopsy were also evaluated. Results: The areas under the curve for the prediction of significant fibrosis (⩾F2), advanced fibrosis (⩾F3) or cirrhosis were 0.91, 0.99 and 0.98, respectively. Calculation of multilevel likelihood ratios showed that values of TE
- Published
- 2008
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