1. Safety, efficacy and impact on frailty of mini-invasive radial balloon aortic valvuloplasty
- Author
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Caterina Cavazza, Fabio Tarantino, Tommaso Piva, Matteo Serenelli, Marco Balducelli, Andrea Picchi, Enrico Cerrato, Tiziana Attisano, Gerlando Preti, Massimo Di Marco, Gianluca Campo, Carlo Penzo, Giacomo Mantovani, Giuseppe Colonna, Francesco Saia, Annamaria Di Cesare, Matteo Tebaldi, Gianni Dall'Ara, Luca Fileti, Benedetta Govoni, Simone Biscaglia, Cristina Rolfo, Giuseppe De Iaco, Andrea Santarelli, Guido Parodi, Simona Pierini, and Carlo Tumscitz
- Subjects
Balloon Valvuloplasty ,Male ,medicine.medical_specialty ,Transcatheter aortic ,medicine.medical_treatment ,aortic valve stenosis ,Balloon ,NO ,Mini invasive surgery ,Quality of life ,Internal medicine ,Clinical endpoint ,medicine ,Humans ,Prospective Studies ,Mortality ,Aged, 80 and over ,Frailty ,business.industry ,Prognosis ,medicine.disease ,transcatheter aortic valve replacement ,Aortic valvuloplasty ,Aortic valve stenosis ,Radial Artery ,Quality of Life ,Cardiology ,Feasibility Studies ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
ObjectiveThe study was designed to: (1) confirm safety and feasibility of mini-invasive radial balloon aortic valvuloplasty (BAV); (2) assess its impact in terms of quality of life and frailty; and (3) evaluate whether changes in frailty after BAV are associated with death in patients undergoing transcatheter aortic valve implantation (TAVI).Methods330 patients undergoing BAV in 16 Italian centres were prospectively included. The primary endpoint was the occurrence of major and minor Valve Academic Research Consortium (VARC)-2 bleeding. Secondary endpoints were scales of quality of life, frailty, evaluated at baseline and 30 days, and their relationship with the occurrence of all-cause death.ResultsBAV was performed by radial access in 314 (95%) patients. No VARC-2 major and six (1.8%) VARC-2 minor bleedings occurred in the study population. Quality of life, as well as frailty status, significantly improved 30 days after BAV. At 1 year, patients undergoing TAVI with baseline essential frailty toolset (EFT) ConclusionsMini-invasive radial BAV is safe, feasible and associated with a low rate of vascular complications. Patients improving EFT 30 days after BAV showed a favourable outcome after TAVI.Trial registration numberNCT03087552.
- Published
- 2021