1. Mortality from cancer and other causes among Italian chrysotile asbestos miners
- Author
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Enrico Pira, Canzio Romano, Carlo La Vecchia, Claudio Pelucchi, Francesca De' Donato, Paolo Boffetta, and Pira, E. and Romano, C. and Donato, F. and Pelucchi, C. and Vecchia, C.L. and Boffetta, P.
- Subjects
Male ,Mesothelioma ,Lung Neoplasms ,very elderly, chrysotile, Aged ,groups by age ,pleural cancer ,peritoneum cancer ,pharynx cancer ,Cumulative Exposure ,asbestosi ,medicine.disease_cause ,lung tumor ,Cohort Studies ,Toxicology ,violence ,0302 clinical medicine ,Cause of Death ,Neoplasms ,cancer mortality ,Chrysotile ,80 and over ,Poisson Distribution ,030212 general & internal medicine ,Pleural Neoplasm ,Aged, 80 and over ,sensitivity analysi ,Middle Aged ,030210 environmental & occupational health ,cerebrovascular disease ,Occupational Diseases ,esophagus cancer ,priority journal ,Italy ,employment ,Cohort ,Pleural Cancer ,epidemiology ,Public Health ,Asbestos ,chrysotile ,lung cancer ,mining ,Aged ,Asbestos, Serpentine ,Chronic Disease ,Environmental Monitoring ,Humans ,Mining ,Mortality ,Occupational Exposure ,Pleural Neoplasms ,Public Health, Environmental and Occupational Health ,Human ,cohort analysi ,miner ,Article ,smoking ,pleura tumor ,03 medical and health sciences ,adverse effect ,medicine ,follow up ,tuberculosi ,Lung cancer ,liver cirrhosi ,business.industry ,Serpentine ,Environmental and Occupational Health ,Mesothelioma, Malignant ,pleura cancer ,larynx cancer ,Cancer ,accident ,mouth cancer ,medicine.disease ,ischemic heart disease ,major clinical study ,chrysotile asbestos miner ,Lung Neoplasm ,Occupational Disease ,Standardized mortality ratio ,Neoplasm ,Cohort Studie ,business ,chronic obstructive lung disease ,Demography - Abstract
Objective To investigate the long-term mortality of a cohort of Italian asbestos miners. Methods The cohort included 1056 men employed in a chrysotile mine between 1930 and 1990, who were followed up during 1946-2014, for a total of 37 471 person-years of observation. Expected deaths and SMRs were computed using national and local (after 1980, when available) reference. Results A total of 294 (27.8%) subjects were alive and at the end of follow-up, 722 (68.4%) were dead and 40 (3.8%) were lost to follow-up. The SMR for overall mortality was 1.35 (95%CI 1.25 to 1.45). The SMR for pleural cancer, based on seven observed deaths, was 5.54 (95% CI 2.22 to 11.4) and related to time since first exposure, but not to duration of employment, cumulative exposure or time since last exposure. The SMR for lung cancer was 1.16 (95% CI 0.87 to 1.52; 53 observed deaths), with no excess among workers with cumulative exposure below 100 fibre/mL-years (SMR 0.82; 95% CI 0.44 to 1.40). Conclusions The update of the follow-up of this cohort confirmed an increased mortality from pleural cancer mortality in miners exposed to chrysotile and a lack of significant increase in lung cancer mortality. © Article author(s) 2017 (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. No commercial use is permitted unless otherwise expressly granted.
- Published
- 2017