1. Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation
- Author
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Carmine M. Pariante, Katrina A. S. Davis, Alexandru Dregan, David Armstrong, Lisa Harber-Aschan, Lauren Rayner, Robert Stewart, Matthew Hotopf, Anamaria Brailean, Stephani L. Hatch, and Faith Matcham
- Subjects
Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Epidemiology ,Autoimmune diseases ,Immunology ,Context (language use) ,Anxiety ,General Biochemistry, Genetics and Molecular Biology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Quality of life ,Rheumatic Diseases ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,Prospective cohort study ,Depression (differential diagnoses) ,Aged ,Inflammation ,030203 arthritis & rheumatology ,Primary Health Care ,Depression ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,Middle Aged ,medicine.disease ,Primary care ,Mental health ,Chronic Disease ,Female ,medicine.symptom ,business ,Systemic vasculitis - Abstract
Background: There is inconsistent evidence about the association between inflammatory disorders with depression and anxiety onset in a primary care context. The study aimed evaluate the risk of depression and anxiety within multisystem and organ-specific inflammatory disorders. Methods: Prospective cohort study with primary care patients from the UK Clinical Practice Research Datalink diagnosed with an inflammatory disorder between 1st of January 2001 and 31st of December 2016. These patients were matched on age, gender, practice, and index date with patients without an inflammatory disorder. The study exposures were seven chronic inflammatory disorders. Clinical diagnosis of depression and anxiety represented the outcome measures of interest. Findings: Among 538,707 participants, the incidence of depression ranged from 14 per 1000 person-years (severe psoriasis) to 9 per 1000 person-years (systemic vasculitis), substantively higher compared to their comparison group (5 to 7 per 1000 person-years). Hazard ratios (HR) of multiple depression and anxiety events were 16% higher within inflammatory disorders (HR, 1·16, 95%CI 1·12-1·21, p
- Published
- 2019