1. ECG non-specific ST-T and QTc abnormalities in patients with systemic lupus erythematosus compared with rheumatoid arthritis
- Author
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Joan M. Bathon, Paloma Pina, Anca Askanase, Jon T. Giles, Afshin Zartoshti, Yevgeniya Gartshteyn, Marina Cerrone, and Laura Geraldino-Pardilla
- Subjects
medicine.medical_specialty ,Immunology ,Population ,Disease ,030204 cardiovascular system & hematology ,QT interval ,03 medical and health sciences ,0302 clinical medicine ,Non specific ,Internal medicine ,Medicine ,In patient ,cardiovascular diseases ,skin and connective tissue diseases ,education ,Cause of death ,030203 arthritis & rheumatology ,education.field_of_study ,biology ,business.industry ,C-reactive protein ,General Medicine ,medicine.disease ,Surgery ,Rheumatoid arthritis ,biology.protein ,business - Abstract
Objectives Cardiovascular disease (CVD) is a leading cause of death in systemic lupus erythematosus (SLE) and in rheumatoid arthritis (RA). Although only explored in one study, ECG non-specific ST-T abnormalities, in addition to corrected QT-interval (QTc) prolongation, were recently reported in an SLE inception cohort. Importantly, these ECG abnormalities are known predictors of CVD mortality in the general population, yet their prevalence in patients with established SLE has not been evaluated. Methods We cross-sectionally investigated the presence of non-specific ST-T and QTc abnormalities in 50 patients with SLE, predominantly Hispanic and black, without CVD or SLE-related cardiac involvement and compared them with 139 patients with RA without CVD. Demographics, disease-specific characteristics and CVD risk factors were ascertained and adjusted for. Results Patients with SLE (mean age 36±13 years, 92% women, 6 years median disease duration, 96% Hispanics and blacks) had a 3.3-fold higher adjusted prevalence of non-specific ST-T abnormalities (56% vs 17%; p
- Published
- 2016