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Abstract Despite advancements in occupational health and safety (OHS) management, high-risk industries in China continue to report a significant number of fatal accidents, underscoring systemic challenges in protecting the well-being of workers while supporting economic development. This study analyzed 22 years of historical data on OHS incidents, labor dynamics, and economic growth in China’s high-risk industries via multiple regression and network analysis methods. The findings reveal hierarchical influence relationships, with coal mine fatalities emerging as critical upstream factors and transportation fatalities and national labor force dynamics emerging as key downstream factors. Notably, the study reveals a negative correlation between GDP and fatal workplace incidents: for every 0.461 trillion CNY increase in GDP, production safety accident deaths decrease by one. Conversely, each safety accident resulted in 1.052 coal mine fatalities and 0.153 cases of occupational disease. These results offer a novel quantitative perspective on the interplay between economic growth and workplace safety. The study’s models provide practical guidance for enhancing the effectiveness of OHS prevention and control efforts, contributing to sustainable economic and public health outcomes.

Abstract Background Planarians reliably regenerate all body parts after injury, including a fully functional head and central nervous system. But until now, the expression dynamics and functional role of miRNAs and other small RNAs during the process of head regeneration are not well understood. Furthermore, little is known about the evolutionary conservation of the relevant small RNAs pathways, rendering it difficult to assess whether insights from planarians will apply to other taxa. Results In this study, we applied high throughput sequencing to identify miRNAs, tRNA fragments and piRNAs that are dynamically expressed during head regeneration in Dugesia japonica. We further show that knockdown of selected small RNAs, including three novel Dugesia-specific miRNAs, during head regeneration induces severe defects including abnormally small-sized eyes, cyclopia and complete absence of eyes. Conclusions Our findings suggest that a complex pool of small RNAs takes part in the process of head regeneration in Dugesia japonica and provide novel insights into global small RNA expression profiles and expression changes in response to head amputation. Our study reveals the evolutionary conserved role of miR-124 and brings further promising candidate small RNAs into play that might unveil new avenues for inducing restorative programs in non-regenerative organisms via small RNA mimics based therapies.