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1 results on '"Shu-Xin Lu"'

1. Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case–control study

Author

Tzu-Wei Wu, Chao-Liang Chou, Chun-Fang Cheng, Shu-Xin Lu, Yih-Jer Wu, and Li-Yu Wang

Subjects
Carotid atherosclerosis, Case–control study, Community-based study, Diabetes mellitus, FTO gene, Genetic association study, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Diabetes mellitus (DM) is a well-established determinant of atherosclerosis and cardiovascular diseases (CVD). Recently, genome-wide association studies (GWAS) identified several single nucleotide polymorphism (SNP) significantly correlated with DM. The study aimed to explore the relationships of the top significant DM SNPs with carotid atherosclerosis (CA). Methods We used a case–control design and randomly selected 309 cases and 439 controls with and without, respectively, carotid plaque (CP) from a community-based cohort. Eight recent GWAS on DM in East Asians reported hundreds of SNPs with genome-wide significance. The study used the top significant DM SNPs, with a p-value

Published
2023
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