1. A retrospective study on the influence of siblings’ relatedness in Bolivian patients with chronic Chagas disease
- Author
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Espinosa-Pereiro, Juan, Sánchez-Montalvá, Adrián, Salvador, Fernando, Sao-Avilés, Augusto, Sulleiro, Elena, Molina Romero, Israel, Universitat Autònoma de Barcelona. Departament de Medicina, Institut Català de la Salut, [Espinosa-Pereiro J] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de Salut Internacional de l'Institut Català de la Salut (PROSICS), Barcelona, Spain. [Sánchez-Montalvá A, Salvador F, Molina I] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de Salut Internacional de l'Institut Català de la Salut (PROSICS), Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. [Sao-Avilés A] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de Salut Internacional de l'Institut Català de la Salut (PROSICS), Barcelona, Spain. Unitat d'ecocardiografia i imatge cardíaca, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sulleiro E] Servei de Microbiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona Barcelona, Spain., and Vall d'Hebron Barcelona Hospital Campus
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0301 basic medicine ,Chagas Cardiomyopathy ,Male ,Chagas disease ,Gastrointestinal Diseases ,Disease ,enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas [ENFERMEDADES] ,0302 clinical medicine ,Risk Factors ,Reacció en cadena de la polimerasa ,personas::hermanos [DENOMINACIONES DE GRUPOS] ,técnicas de investigación::técnicas genéticas::técnicas de amplificación de ácidos nucleicos::reacción en cadena de la polimerasa [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Sang - Anàlisi ,Gastrointestinal disease ,Trypanocidal Agents ,Delayed type hypersensitivity ,Infectious Diseases ,Benznidazole ,Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Female ,Brotherhood ,Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease [DISEASES] ,medicine.drug ,Adult ,medicine.medical_specialty ,Bolivia ,Persons::Siblings [NAMED GROUPS] ,Chagas, Malaltia de ,Cardiomyopathy ,Concordance ,Trypanosoma cruzi ,030231 tropical medicine ,Biology ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Internal medicine ,Protozoan infection ,medicine ,Humans ,Other subheadings::Other subheadings::/blood [Other subheadings] ,lcsh:RC109-216 ,Sibling ,Retrospective Studies ,Research ,Siblings ,Retrospective cohort study ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,Chronic Disease ,Parasitology ,Otros calificadores::Otros calificadores::/sangre [Otros calificadores] ,Germans i germanes - Malalties - Estudi de casos - Abstract
Background Chagas disease is a protozoan infection caused by Trypanosoma cruzi. The disease has a chronic course in which 20–30% of the patients would develop progressive damage to the cardiovascular system and the gastrointestinal tube. We are still unable to predict who will develop end-organ damage but there are some acquired and genetic risk factors already known. Results We reviewed data from 833 patients with serologically confirmed Chagas disease in this retrospective study. Patients were classified as siblings or non-siblings (controls) and the results of pre-treatment blood PCR assay, end-organ damage (cardiac and/or gastrointestinal), and the presence of delayed type hypersensitivity (DTH) skin involvement in patients treated with benznidazole were analyzed. Siblings were grouped by family and we randomly generated groups of 2 or 3 persons with the remaining controls. We classified the results of each variable as concordant or discordant and compared the concordance in these results among the sibling groups with that among control groups. We identified 71 groups of siblings and randomly generated 299 groups of non-related patients. Pre-treatment blood PCR concordance was significantly higher (19%) among siblings compared to controls (P = 0.02), probably due to a higher frequency in pre-treatment positive results. No other statistically significant differences were found. Conclusions A significant difference was found in the concordance of pre-treatment blood PCR for T. cruzi among siblings compared to non-related controls. Electronic supplementary material The online version of this article (10.1186/s13071-019-3518-4) contains supplementary material, which is available to authorized users.
- Published
- 2019
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