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Abstract Background Septoria tritici blotch (STB) is one of the most damaging wheat diseases worldwide, and the development of resistant cultivars is of paramount importance for sustainable crop management. However, the genetic basis of the resistance present in elite wheat cultivars remains largely unknown, which limits the implementation of this strategy. A collection of 285 wheat cultivars originating mostly from France was challenged with ten Zymoseptoria tritici isolates at the seedling stage. The collection was further evaluated in seven field trials across France using artificial inoculation. Results Genome-wide association study resulted in the detection of 57 wheat QTL, among which 40 were detected at the seedling stage. Three quarters of these QTL were in genomic regions previously reported for to confer resistance to Z. tritici, but 10 QTL are novel and may be of special interest as new sources of resistance. Some QTL colocalise with major Stb resistance genes, suggesting their presence in the French elite winter wheat germplasm. Among them, the three QTL with the strongest effect colocalize with Stb6, Stb9 and Stb18. There was minimal overlap between the QTL detected at the seedling and adult plant stages, with only 1 out of 20 seedling QTL also being detected in field trials inoculated with the same isolate. This suggests that different resistance genes are involved at the seedling and adult plant stages. Conclusion This work reveals the highly complex genetic architecture of French wheat resistance to STB and provides relatively small QTL intervals, which will be valuable for identifying the underlying causative genes and for marker-assisted selection.

Abstract Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients according to their disease subgroup and predicted response to treatment. The EULAR Synovitis Study Group and the OMERACT synovial tissue biopsy (STB) Special Interests Group have undertaken a consensus exercise to identify factors that are important for the standardisation of STB handling and analytical procedures in two situations—clinical practice and translational research.