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Start Over Descriptor "Reproductive impairment" Publisher bmc
1 results on '"Reproductive impairment"'

1. Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain

Author

Yu-Xiang Zheng, Xiu-Xiang Zhang, Jorge A. Hernandez, Yasser S. Mahmmod, Wan-Yi Huang, Gui-Feng Li, Ya-Pei Wang, Xue Zhou, Xiu-Ming Li, and Zi-Guo Yuan

Subjects
Toxoplasma gondii, Chronic infection, Reproductive impairment, DEGs, RNA-seq, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Some researchers have reported that Toxoplasma gondii can cause serious reproductive impairment in male animals. Specifically, T. gondii destroy the quality of sperm in the epididymis, which affects their sexual ability. However, among such studies, none have investigated the male reproductive transcriptome. Therefore, to investigate the relationship between T. gondii and sperm maturation, we infected mice with T. gondii prugniaud (PRU) strain and performed transcriptome sequencing of the epididymis. Results Compared with the control group, 431 upregulated and 229 downregulated differentially expressed genes (DEGs) were found (P-value

Published
2019
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