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1. SIVΔnef vaccination mobilizes systemic and mucosal natural killer cells in Mamu A*01+ macaques

Author

Michelle Connole, Roger Keith Reeves, Fay E. Wong, Yi Yu, R P Johnson, Jacqueline Gillis, and Tristan I. Evans

Subjects
Vaccination, lcsh:Immunologic diseases. Allergy, Innate immune system, Immune system, Infectious Diseases, animal diseases, Virology, biology.protein, Oral Presentation, Biology, Antibody, lcsh:RC581-607
Abstract

Background Although vaccination with live attenuated SIV is the most effective means of inducing protection against lentiviruses, the immunologic mechanisms responsible remain unclear. Previous studies have yielded conflicting data regarding the role of adaptive immune responses in mediating protection, suggesting that innate immune responses, including natural killer (NK) cells, may play a role.

Published
2012

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