1. HHV-8 reduces dendritic cell migration through down-regulation of cell-surface CCR6 and CCR7 and cytoskeleton reorganization
- Author
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Pankaj Trivedi, Sandro Valia, Marisa Granato, Mara Cirone, Antonella Farina, Roberta Santarelli, Alberto Faggioni, Valeria Conte, Luigi Frati, Department of Experimental Medicine [Roma], Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], and This work was partially supported by grants from MIUR, Associazione Italiana per la ricerca sul Cancro (AIRC), progetto strategico ISS 9ACF/1 of Ministero della salute and Pasteur Cenci-Bolognetti foundation.
- Subjects
CCR1 ,viruses ,C-C chemokine receptor type 6 ,MESH: Receptors, CCR6 ,MESH: Receptors, CCR7 ,MESH: Down-Regulation ,Chemokine receptor ,0302 clinical medicine ,Cell Movement ,Dendritic cells ,MESH: Immune Evasion ,MESH: Cell Movement ,Cytoskeleton ,0303 health sciences ,MESH: Dendritic Cells ,virus diseases ,Cell biology ,Infectious Diseases ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Herpesvirus 8, Human ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Chemokines ,Receptors, CCR6 ,Receptors, CCR7 ,Short Report ,Down-Regulation ,chemical and pharmacologic phenomena ,Biology ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Virology ,MESH: Cytoskeleton ,Humans ,lcsh:RC109-216 ,Dendritic cell migration ,CXCL16 ,HHV-8 ,030304 developmental biology ,Immune Evasion ,MESH: Herpesvirus 8, Human ,MESH: Humans ,Chemokine receptors ,Dendritic Cells ,biochemical phenomena, metabolism, and nutrition ,dendritic cells ,hhv-8 ,chemokine receptors ,chemokines ,CCL25 ,CC chemokine receptors ,030215 immunology ,CCL21 - Abstract
Background For an efficient immune response against viral infection, dendritic cells (DCs) must express a coordinate repertoire of receptors that allow their recruitment to the sites of inflammation and subsequently to the secondary lymphoid organs in response to chemokine gradients. Several pathogens are able to subvert the chemokine receptor expression and alter the migration properties of DCs as strategy to escape from the immune control. Findings Here we report the inhibitory effect of Human Herpesvirus 8 (HHV-8) on the migratory behavior of immature and mature DCs. We found that the virus altered the DC chemokine receptor expression and chemokine induced migration. Moreover HHV-8 was also able to interfere with basal motility of DCs by inducing cytoskeleton modifications. Conclusion Based on our findings, we suggest that HHV-8 is able to subvert the DC migration capacity and this represents an additional mechanism which interferes with their immune-functions.
- Published
- 2012
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