1. Post-COVID-19 illness and associations with sex and gender
- Author
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Kenneth Mangion, Andrew J. Morrow, Robert Sykes, Anna Kamdar, Catherine Bagot, George Bruce, Paul Connelly, Christian Delles, Vivienne B. Gibson, Lynsey Gillespie, Pauline Hall Barrientos, Vera Lennie, Giles Roditi, Naveed Sattar, David Stobo, Sarah Allwood-Spiers, Alex McConnachie, Colin Berry, and CISCO-19 investigators
- Subjects
COVID-19 ,Severe acute respiratory syndrome coronavirus-19 ,SARS CoV-2 ,Female sex ,Male sex ,Myocarditis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain. Aim There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection. Design This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence. Methods Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28–60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization. Results Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p
- Published
- 2023
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