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1. Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020

Author

Xiaoshan Xu, Liuhong Luo, Chang Song, Jianjun Li, Huanhuan Chen, Qiuying Zhu, Guanghua Lan, Shujia Liang, Zhiyong Shen, Zhiqiang Cao, Yi Feng, Lingjie Liao, Hui Xing, Yiming Shao, and Yuhua Ruan

Subjects
HIV, Pretreatment drug resistance (PDR), Antiretroviral therapy (ART), Drug resistance mutations (DRMs), Genetic transmission networks, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Pretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-positive individuals that initiated antiretroviral therapy in 2014–2020 in southwestern China. Methods Consecutive cross-sectional surveys were conducted in Qinzhou, Guangxi. We obtained blood samples from individuals who were newly diagnosed with HIV in 2014–2020. PDR and genetic networks analyses were performed by HIV-1 pol sequences using the Stanford HIV-database algorithm and HIV-TRACE, respectively. Univariate and multivariate logistic regression models were used to explore the potential factors associated with PDR. Results In total, 3236 eligible HIV-positive individuals were included. The overall prevalence of PDR was 6.0% (194/3236). The PDR frequency to NNRTI (3.3%) was much higher than that of NRTI (1.7%, p

Published
2021
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2. Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020

Author

Zhiqiang Cao, Chang Song, Guanghua Lan, Qiuying Zhu, Liuhong Luo, Zhiyong Shen, Xiaoshan Xu, Yi Feng, Huanhuan Chen, Yuhua Ruan, Yiming Shao, Lingjie Liao, Jianjun Li, Shujia Liang, and Hui Xing

Subjects
China, medicine.medical_specialty, Genotype, Anti-HIV Agents, Genetic transmission networks, HIV Infections, Drug resistance, Infectious and parasitic diseases, RC109-216, Logistic regression, law.invention, Antiretroviral therapy (ART), Medical microbiology, law, Internal medicine, Drug Resistance, Viral, Prevalence, Humans, Medicine, Drug resistance mutations (DRMs), business.industry, Research, Pretreatment drug resistance (PDR), HIV, Odds ratio, Cross-Sectional Studies, Infectious Diseases, Transmission (mechanics), Parasitology, Mutation, Tropical medicine, business, HIV drug resistance
Abstract

BackgroundPretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-positive individuals that initiated antiretroviral therapy in 2014–2020 in southwestern China.MethodsConsecutive cross-sectional surveys were conducted in Qinzhou, Guangxi. We obtained blood samples from individuals who were newly diagnosed with HIV in 2014–2020. PDR and genetic networks analyses were performed by HIV-1 pol sequences using the Stanford HIV-database algorithm and HIV-TRACE, respectively. Univariate and multivariate logistic regression models were used to explore the potential factors associated with PDR.ResultsIn total, 3236 eligible HIV-positive individuals were included. The overall prevalence of PDR was 6.0% (194/3236). The PDR frequency to NNRTI (3.3%) was much higher than that of NRTI (1.7%, p ConclusionsThe overall prevalence of PDR was medium, numerous cases of the same DRMs among genetically linked individuals in networks further illustrated the importance of surveillance studies for mitigating PDR.

Published
2021

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