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1. Tolerability of a new amino acid-based formula for children with IgE-mediated cow’s milk allergy

Author

Rita Nocerino, Carmen Di Scala, Serena Coppola, Veronica Giglio, Laura Carucci, Linda Cosenza, Luana Voto, Anna Maria Iannicelli, Anna Luzzetti, and Roberto Berni Canani

Subjects
Infant formula, Hypoallergenic formula, Food allergy, Diet therapy, Pediatrics, RJ1-570
Abstract

Abstract Background Amino acid-based formula (AAF) is a relevant dietary strategy for paediatric patients affected by cow’s milk allergy (CMA). The present study was designed to evaluate the hypoallergenicity of a new AAF in children with immunoglobulin (Ig)E-mediated CMA. Methods According to the criteria provided by the American Academy of Pediatrics Subcommittee on Nutrition and Allergic Diseases, we designed a prospective trial in CMA children (aged 1–36 months) aimed to demonstrate the hypoallergenicity of the new AAF in 90% of subjects with 95% confidence during the double-blind, placebo-controlled challenge (DBPCFC). A skin prick test (SPT) with the new AAF was also performed. Results Twenty-nine children [all Caucasian, 55.2% male, mean age (±SD) 16.9 ± 5.7 months] were enrolled. The SPT and the DBPCFC with the new AAF were negative in all study subjects. Conclusions The study results support the hypoallergenicity of the new AAF. This formula could be considered an additional dietary option for non-breastfed children affected by CMA. Trial registration The trial was registered in the ClinicalTrials.gov Protocol Registration System (ID number: NCT03909113 ).

Published
2021
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2. Tolerability of a new amino acid-based formula for children with IgE-mediated cow’s milk allergy

Author

Laura Carucci, Roberto Berni Canani, Rita Nocerino, Carmen Di Scala, Anna Maria Iannicelli, Veronica Giglio, Serena Coppola, Luana Voto, Linda Cosenza, Anna Luzzetti, Nocerino, Rita, Di Scala, Carmen, Coppola, Serena, Giglio, Veronica, Carucci, Laura, Cosenza, Linda, Voto, Luana, Iannicelli, Anna Maria, Luzzetti, Anna, and Berni Canani, Roberto

Subjects
Male, medicine.medical_specialty, Diet therapy, Milk allergy, Pediatrics, RJ1-570, 03 medical and health sciences, 0302 clinical medicine, Ige mediated, Double-Blind Method, Cow's milk allergy, Food allergy, Internal medicine, medicine, polycyclic compounds, Animals, Humans, Prospective Studies, Amino Acids, Skin Tests, biology, business.industry, Research, Infant, Immunoglobulin E, medicine.disease, Hypoallergenic formula, 030228 respiratory system, Tolerability, Infant formula, Child, Preschool, biology.protein, Cattle, Female, Milk Hypersensitivity, Antibody, business, 030215 immunology
Abstract

Background Amino acid-based formula (AAF) is a relevant dietary strategy for paediatric patients affected by cow’s milk allergy (CMA). The present study was designed to evaluate the hypoallergenicity of a new AAF in children with immunoglobulin (Ig)E-mediated CMA. Methods According to the criteria provided by the American Academy of Pediatrics Subcommittee on Nutrition and Allergic Diseases, we designed a prospective trial in CMA children (aged 1–36 months) aimed to demonstrate the hypoallergenicity of the new AAF in 90% of subjects with 95% confidence during the double-blind, placebo-controlled challenge (DBPCFC). A skin prick test (SPT) with the new AAF was also performed. Results Twenty-nine children [all Caucasian, 55.2% male, mean age (±SD) 16.9 ± 5.7 months] were enrolled. The SPT and the DBPCFC with the new AAF were negative in all study subjects. Conclusions The study results support the hypoallergenicity of the new AAF. This formula could be considered an additional dietary option for non-breastfed children affected by CMA. Trial registration The trial was registered in the ClinicalTrials.gov Protocol Registration System (ID number: NCT03909113).

Published
2021

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