1. Frailty and pre-frailty in cardiac surgery: a systematic review and meta-analysis of 66,448 patients
- Author
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Jessica Avery Lee, Bobby Yanagawa, Kevin R. An, Rakesh C. Arora, Subodh Verma, Jan O. Friedrich, and on behalf of the Canadian Cardiovascular Surgery Meta-Analysis Working Group
- Subjects
Frailty ,Coronary artery bypass graft ,Valve surgery ,Surgery ,RD1-811 ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Background The burden of frailty on cardiac surgical outcomes is incompletely understood. Here we perform a systematic review and meta-analysis of studies comparing frail versus pre-frail versus non-frail patients following cardiac surgery. Methods We searched MEDLINE and EMBASE databases until July 2018 for studies comparing cardiac surgery outcomes in “frail”, “pre-frail” and “non-frail” patients. Data was extracted in duplicate. Primary outcome was operative mortality. Results There were 19 observational studies with 66,448 patients. Frail patients were more likely female (risk ratio [RR]1.7; 95%CI:1.5–1.9), older (mean difference: 2.4; 95%CI:1.3–3.5 years older) with greater comorbidities and higher STS-PROM. Frailty (RR2.35; 95%CI:1.57–3.51; p
- Published
- 2021
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