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2 results on '"Iris Erlund"'

1. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial

Author

Siv K. Bøhn, Mari C. W. Myhrstad, Magne Thoresen, Iris Erlund, Ann Kristin Vasstrand, Anne Marciuch, Monica H. Carlsen, Nasser E. Bastani, Knut Engedal, Kjell M. Flekkøy, and Rune Blomhoff

Subjects
Bilberry, blueberry, blueberries, Grape, Cytokines, Memory, Inflammation, Aged men, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456, Medicine (General), R5-920
Abstract

Abstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment. Methods Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention. Results Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]). Conclusions The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established. Trial registration Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.

Published
2021
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2. Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers

Author

C A Drevon, Harald Arnesen, Anette Karlsen, Siv Kjølsrud Bøhn, Magne Thoresen, Marit Holden, Siv H. Tunheim, Jan Ø Moskaug, Mari C. W. Myhrstad, Ingebjørg Seljeflot, Iris Erlund, Asim K. Duttaroy, Andrew Collins, Petter Laake, Serena Tonstad, Mette Svendsen, and Rune Blomhoff

Subjects
Male, Aryl hydrocarbon receptor nuclear translocator, DNA repair, Gene Expression, lcsh:Medicine, Pharmacology, Biology, medicine.disease_cause, Antioxidants, Beverages, Blood cell, Vegetables, Gene expression, medicine, Humans, Nuts, Gene, Medicine(all), Genetics, Analysis of Variance, Blood Cells, Tea, Gene Expression Profiling, Smoking, lcsh:R, General Medicine, Middle Aged, Aryl hydrocarbon receptor, Diet, Gene expression profiling, Oxidative Stress, medicine.anatomical_structure, Food, Fruit, Seeds, biology.protein, Oxidative stress, Research Article
Abstract

Background Plant-based diets rich in fruit and vegetables can prevent development of several chronic age-related diseases. However, the mechanisms behind this protective effect are not elucidated. We have tested the hypothesis that intake of antioxidant-rich foods can affect groups of genes associated with cellular stress defence in human blood cells. Trial registration number: NCT00520819 http://clinicaltrials.gov. Methods In an 8-week dietary intervention study, 102 healthy male smokers were randomised to either a diet rich in various antioxidant-rich foods, a kiwifruit diet (three kiwifruits/d added to the regular diet) or a control group. Blood cell gene expression profiles were obtained from 10 randomly selected individuals of each group. Diet-induced changes on gene expression were compared to controls using a novel application of the gene set enrichment analysis (GSEA) on transcription profiles obtained using Affymetrix HG-U133-Plus 2.0 whole genome arrays. Results Changes were observed in the blood cell gene expression profiles in both intervention groups when compared to the control group. Groups of genes involved in regulation of cellular stress defence, such as DNA repair, apoptosis and hypoxia, were significantly upregulated (GSEA, FDR q-values < 5%) by both diets compared to the control group. Genes with common regulatory motifs for aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (AhR/ARNT) were upregulated by both interventions (FDR q-values < 5%). Plasma antioxidant biomarkers (polyphenols/carotenoids) increased in both groups. Conclusions The observed changes in the blood cell gene expression profiles suggest that the beneficial effects of a plant-based diet on human health may be mediated through optimization of defence processes.

Published
2010

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