1. Thyroid function spectrum in Cushing’s syndrome
- Author
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Peng Yu, Haoyue Yuan, Hong Chen, and Xiaomu Li
- Subjects
Cushing’s syndrome ,Thyroid dysfunction ,Diagnosis ,Endocrine pathophysiology ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Purpose Thyroid disorders have been reported in hypercortisolism patients. Endogenous Cushing’s syndrome (CS) potentially complicates its metabolic sequelae. We investigated thyroid function in CS patients to determine this relationship. Methods In this cross-sectional study, we screened CS patients from 2016 to 2019 at our hospital. Patient demographic, medical history, and laboratory data were collected. Additionally, we performed a meta-analysis to demonstrate the prevalence of thyroid dysfunction in patients with CS. Results Among 129 CS patients, 48.6% had triiodothyronine (TT3), 27.9% had thyroxine (TT4), 24.6% had free T3 (FT3), 27.7% had free T4 (FT4), and 6.2% had thyroid-stimulating hormone (TSH) levels below the reference values. Those with clinical CS showed more pronounced thyroid suppression than did those with subclinical CS. Cortisol levels were markedly greater in patients with pituitary hypothyroidism (P
- Published
- 2024
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