1. Anti-leishmanial effects of resveratrol and resveratrol nanoemulsion on Leishmania major
- Author
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Parisa Mousavi, Bahman Rahimi Esboei, Maryam Pourhajibagher, Mahdi Fakhar, Zabihollah Shahmoradi, Seyed Hossein Hejazi, Hadi Hassannia, Ayatollah Nasrollahi Omran, and Hamid Hasanpour
- Subjects
Anti-leishmanial activity ,Leishmania major ,Resveratrol ,Resveratrol nanoemulsion ,Microbiology ,QR1-502 - Abstract
Abstract Background Leishmaniasis is a vector-borne disease that is endemic in the tropical and sub-tropical areas of the world. Low efficacy and high cytotoxicity of the current treatment regimens for leishmaniasis is one of the most important health problems. In this experimental study, anti-leishmanial effects of different concentrations of resveratrol and resveratrol nano-emulsion (RNE) were assessed. Methods RNE was prepared using the probe ultra-sonication method. The cytotoxicity was evaluated using the MTT technique on the L929 cell line. The anti-leishmanial activities on promastigotes of leishmania were assessed using vital staining and infected BALB/c mice were used to assess the in vivo anti-leishmanial effects. Results In vitro and in vivo assays revealed that all concentrations of resveratrol and RNE had valuable inhibitory effects against Leishmania major in comparison to the control group (P
- Published
- 2022
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