1. Usual interstitial pneumonia coexisted with nonspecific interstitial pneumonia, What’s the diagnosis?
- Author
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Gelin Jiang, Yu Zeng, Xia Fang, Fang Liu, Huiping Li, Benfang Luo, Suxia Zhang, Xuyou Zhu, Pan Gu, and Xianghua Yi
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Histology ,Biopsy ,medicine.medical_treatment ,Case Report ,Autopsy ,Severity of Illness Index ,Pathology and Forensic Medicine ,Idiopathic pulmonary fibrosis ,Pneumonectomy ,Fatal Outcome ,Idiopathic nonspecific interstitial pneumonia ,Usual interstitial pneumonia ,Metaplasia ,Diagnosis ,medicine ,lcsh:Pathology ,Humans ,Lung ,medicine.diagnostic_test ,business.industry ,Nonspecific interstitial pneumonia ,General Medicine ,Fibroblasts ,Middle Aged ,respiratory system ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,respiratory tract diseases ,Treatment Outcome ,medicine.anatomical_structure ,medicine.symptom ,Differential diagnosis ,Lung Diseases, Interstitial ,Tomography, X-Ray Computed ,business ,lcsh:RB1-214 - Abstract
The differential diagnosis between idiopathic nonspecific interstitial pneumonia(INSIP) and idiopathic pulmonary fibrosis(IPF)/usual interstitial pneumonia(UIP)is tough in both clinicians and pathologists. In this study, we analyzed the lesions of right lung removed from a 58-year-old patient by gross and microscopy. The results showed that the pathological appearance of nonspecific interstitial pneumonia (NSIP) and UIP coexisted in his upper lobe. Besides, because of severe fibrosis in middle and lower lobes, it was hard to distinguish the lesions of NSIP fibrotic pattern (NSIP-F) or UIP. Based on clinic-radiologic-pathological data, the diagnosis of INSIP-F was made for this patient finally. Our study suggests that UIP is not always an accurate diagnosis when the NSIP and UIP coexist, and NSIP can have regions of UIP. Virtual slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2573531681608730
- Published
- 2012