1. Sheng Mai San protects H9C2 cells against hyperglycemia-induced apoptosis
- Author
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Bing Pang, Li-Wei Shi, Li-juan Du, Yun-Chu Li, Mei-Zhen Zhang, and Qing Ni
- Subjects
Sheng Mai San ,H9C2 cells ,Apoptosis ,Bcl-2/Bax signaling way ,Fas/FasL signaling way ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Sheng Mai San (SMS) has been proven to exhibit cardio-protective effects. This study aimed to explore the molecular mechanisms of SMS on hyperglycaemia (HG)-induced apoptosis in H9C2 cells. Methods HG-induced H9C2 cells were established as the experimental model, and then treated with SMS at 25, 50, and 100 μg/mL. H9C2 cell viability and apoptosis were quantified using MTT and Annexin V-FITC assays, respectively. Furthermore, Bcl-2/Bax signalling pathway protein expression and Fas and FasL gene expression levels were quantified using western blotting and RT-PCR, respectively. Results SMS treatments at 25, 50, 100 μg/mL significantly improved H9C2 cell viability and inhibited H9C2 cell apoptosis (p
- Published
- 2019
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