1. Oestrogen receptor assay of breast cancer by immunocytochemistry of fine needle aspirates.
- Author
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Kitchen PR, Stillwell RG, Henderson MA, Bennett RC, Rennie GC, Kou SJ, Georgiou T, and Ayberk H
- Subjects
- Adenocarcinoma, Mucinous metabolism, Adenocarcinoma, Mucinous pathology, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Female, Humans, Immunohistochemistry standards, Radioligand Assay standards, Sensitivity and Specificity, Biopsy, Needle, Breast pathology, Breast Neoplasms metabolism, Carcinoma, Intraductal, Noninfiltrating metabolism, Receptors, Estrogen analysis
- Abstract
Sixty-five patients with operable breast cancer were studied to assess the reliability of immunocytochemical analysis of oestrogen receptor (ER-ICA) in specimens obtained by percutaneous fine needle aspiration. Results obtained with the commercially available ER-ICA kit were compared with those obtained by the routine biochemical radioligand assay of oestrogen receptor (ER) on excised tumour specimens. Fifty-two of 65 percutaneous aspirates were evaluable. Of these, thirty-five (67%) were ER positive by the radioligand method. ER-ICA was found to be a reliable method for oestrogen receptor assay, with a high concordance (90.4%) between it and the radioligand essay. The ER-ICA assay had a sensitivity of 89%, specificity of 94%, positive predictive value of 97% and negative predictive value of 80%. ER-ICA assay performed on material obtained by fine-needle aspiration is a reliable method of ER assay. It can replace formal biopsy for patients with inoperable primary tumours or accessible metastases.
- Published
- 1991
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