1. Increased survival by feeding tetradecylthioacetic acid during a natural outbreak of heart and skeletal muscle inflammation in S0 Atlantic salmon, Salmo salar L.
- Author
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Alne H, Thomassen MS, Takle H, Terjesen BF, Grammes F, Oehme M, Refstie S, Sigholt T, Berge RK, and Rørvik KA
- Subjects
- Administration, Oral, Animals, Body Weight drug effects, Fish Diseases mortality, Gene Expression Regulation drug effects, Heart drug effects, Lipid Metabolism drug effects, Muscle, Skeletal drug effects, Muscle, Skeletal pathology, Myocarditis drug therapy, Myocarditis mortality, Myocardium pathology, Myositis drug therapy, Myositis mortality, Random Allocation, Sulfides pharmacology, Survival Analysis, Urea blood, Fatty Acids therapeutic use, Fish Diseases drug therapy, Myocarditis veterinary, Myositis veterinary, Salmo salar physiology, Sulfides therapeutic use
- Abstract
We have previously documented increased survival by feeding tetradecylthioacetic acid (TTA) during a natural outbreak of infectious pancreatic necrosis in post-smolt S1 Atlantic salmon. The aim of the present study was to test the effects of dietary TTA in S0 smolt at a location where fish often experience natural outbreaks of heart and skeletal muscle inflammation (HSMI) during their first spring at sea. The experimental groups were fed a diet supplemented with 0.25% TTA for a 6-week period prior to a natural outbreak of HSMI in May 2007. Relative percent survival for the groups fed TTA was 45% compared with control diets, reducing mortality from 4.7% to 2.5%. Expression of genes related to lipid oxidation was higher in cardiac ventricles from salmon fed TTA compared with controls. In addition, salmon fed TTA had periodically reduced levels of plasma urea, and increased cardiosomatic index and growth. Reduced mortality and increased growth after administration of TTA may be related to a combination of anti-inflammatory effects, and an altered metabolic balance with better protein conservation because of increased lipid degradation.
- Published
- 2009
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