1. Evolution of the MIP family of integral membrane transport proteins.
- Author
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Pao GM, Wu LF, Johnson KD, Höfte H, Chrispeels MJ, Sweet G, Sandal NN, and Saier MH Jr
- Subjects
- Amino Acid Sequence, Animals, Bacterial Proteins chemistry, Molecular Sequence Data, Phylogeny, Plant Proteins chemistry, Sequence Alignment, Sequence Homology, Nucleic Acid, Biological Evolution, Carrier Proteins chemistry, Membrane Proteins chemistry
- Abstract
Six integral membrane proteins of bacterial, animal, and plant origin, which are believed to function in solute transport, share sequence identity and are grouped together as members of the MIP family. These include the Escherichia coli glycerol facilitator, the major intrinsic protein from bovine lens fibre junction membranes, a plant tonoplast membrane protein, a soybean protein from the peribacteroid membrane, and a Drosophila neurogenic protein. These proteins, each of which appears to consist of six transmembrane helical segments per subunit, apparently arose by internal duplication of a three-transmembrane segment. Phylogenetic 'trees' interrelating these proteins and segments are presented.
- Published
- 1991
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