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1. Itraconazole treatment of experimental systemic candidiasis in male rats.

Author

Yozwiak ML and Galgiani JN

Subjects
Animals, Antifungal Agents administration & dosage, Dose-Response Relationship, Drug, Itraconazole, Ketoconazole administration & dosage, Ketoconazole therapeutic use, Male, Rats, Rats, Inbred Strains, Antifungal Agents therapeutic use, Candidiasis drug therapy, Ketoconazole analogs & derivatives
Abstract

After intravenous infection with Candida albicans, rats received daily doses of itraconazole for 3 days. All rats receiving 2.5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. With subsequent reduction of the itraconazole dose to 0.63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group.

Published
1987
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