1. Utility of positive core number on MRI-ultrasound fusion targeted biopsy in combination with PI-RADS scores for predicting unexpected extracapsular extension of clinically localized prostate cancer.
- Author
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Kobayashi M, Matsuoka Y, Uehara S, Tanaka H, Fujiwara M, Nakamura Y, Ishikawa Y, Fukuda S, Waseda Y, Tanaka H, Yoshida S, and Fujii Y
- Subjects
- Humans, Male, Aged, Middle Aged, Magnetic Resonance Imaging methods, Ultrasonography, Interventional, Retrospective Studies, Biopsy, Large-Core Needle methods, Extranodal Extension diagnostic imaging, Extranodal Extension pathology, Predictive Value of Tests, Prostatic Neoplasms pathology, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms surgery, Image-Guided Biopsy methods, Prostatectomy methods, Prostate pathology, Prostate diagnostic imaging, Prostate surgery
- Abstract
Objectives: To evaluate the utility of magnetic resonance imaging (MRI) and MRI-ultrasound fusion targeted biopsy (TB) for predicting unexpected extracapsular extension (ECE) in clinically localized prostate cancer (CLPC)., Methods: This study enrolled 89 prostate cancer patients with one or more lesions showing a Prostate Imaging-Reporting and Data System (PI-RADS) score ≥3 but without morphological abnormality in the prostatic capsule on pre-biopsy MRI. All patients underwent TB and systematic biopsy followed by radical prostatectomy (RP). Each lesion was examined by 3-core TB, taking cores from each third of the lesion. The preoperative variables predictive of ECE were explored by referring to RP specimens in the lesion-based analysis., Results: Overall, 186 lesions, including 81 (43.5%), 73 (39.2%), and 32 (17.2%) with PI-RADS 3, 4, and 5, respectively, were analyzed. One hundred and twenty-two lesions (65.6%) were diagnosed as cancer on TB, and ECE was identified in 33 (17.7%) on the RP specimens. The positive TB core number was ≤2 in 129 lesions (69.4%) and three in 57 lesions (30.6%). On the multivariate analysis, PI-RADS ≥4 (p = 0.049, odds ratio [OR] = 2.39) and three positive cores on TB (p = 0.005, OR = 3.07) were independent predictors of ECE. Lesions with PI-RADS ≥4 and a positive TB core number of 3 had a significantly higher rate of ECE than those with PI-RADS 3 and a positive TB core number ≤2 (37.5% vs. 7.8%, p < 0.001)., Conclusions: Positive TB core number in combination with PI-RADS scores is helpful to predict unexpected ECE in CLPC., (© 2024 The Japanese Urological Association.)
- Published
- 2024
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