1. CD8(+)/perforin/granzyme B(+) effector cells infiltrating cerebellum and inferior olives in gluten ataxia.
- Author
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Mittelbronn M, Schittenhelm J, Bakos G, de Vos RA, Wehrmann M, Meyermann R, and Bürk K
- Subjects
- Aged, Astrocytes pathology, Astrocytes ultrastructure, Ataxia diet therapy, Ataxia pathology, Brain pathology, Brain ultrastructure, CD8 Antigens metabolism, Celiac Disease diet therapy, Celiac Disease pathology, Cell Death, Cerebellum metabolism, Cerebellum pathology, Cerebellum ultrastructure, Fatal Outcome, Gliosis metabolism, Gliosis pathology, Granzymes metabolism, Humans, Killer Cells, Natural metabolism, Killer Cells, Natural pathology, Killer Cells, Natural ultrastructure, Lymphocytes pathology, Lymphocytes ultrastructure, Male, Microglia pathology, Microglia physiology, Microglia ultrastructure, Neurons pathology, Neurons ultrastructure, Olivary Nucleus metabolism, Olivary Nucleus pathology, Olivary Nucleus ultrastructure, Perforin metabolism, T-Lymphocytes metabolism, T-Lymphocytes pathology, T-Lymphocytes ultrastructure, Ataxia metabolism, Brain metabolism, Celiac Disease metabolism, Lymphocytes metabolism
- Abstract
Up to 8% of patients with gluten sensitivity (GS) develop neurological symptoms such as ataxia, dementia, seizures or peripheral neuropathy. The underlying immunological mechanisms still remain to be elucidated. We here report the case of a 68-year-old male patient suffering from progressive ataxia and dementia associated with chronic diarrhea and both elevated IgG and IgA antigliadin-antibodies. At autopsy, frequent argyrophilic glial and neuronal inclusions within the basal nucleus of Meynert were considered as the structural correlative for the cognitive decline. Significant neuronal loss in the cerebellar cortex and the inferior olives was accompanied by infiltrating CD8(+)/perforin(+)/granzyme B(+) cells as well as reactive astrogliosis and microglial activation. These CD8(+) cytotoxic T and NK cells are likely to act as effector cells responsible for neuronal cell death in patients with gluten sensitivity and neurological disease and might therefore at least partly be responsible for cerebellar symptoms in gluten ataxia. In conclusion, our results, showing an absence of B- or plasma cells but multiple CD8(+) as well as granzyme B and perforin expressing cells in ataxia-associated brain areas, suggest that there are also prominent cytotoxic effects in neuropathogenesis of GS.
- Published
- 2010
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