1. Cocaine-associated atypical haemolytic uraemic syndrome in a genetically susceptible individual.
- Author
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Bongetti E, Kavanagh D, Martin K, Bendall A, Hill P, Steinberg A, Rajaram Y, and Ierino F
- Subjects
- Biopsy methods, Humans, Kidney pathology, Kidney physiopathology, Kidney Function Tests methods, Male, Middle Aged, Mutation, Prognosis, Renal Dialysis methods, Thrombotic Microangiopathies etiology, Thrombotic Microangiopathies pathology, Treatment Outcome, Antibodies, Monoclonal, Humanized administration & dosage, Atypical Hemolytic Uremic Syndrome genetics, Atypical Hemolytic Uremic Syndrome physiopathology, Atypical Hemolytic Uremic Syndrome therapy, Cocaine Smoking adverse effects, Cocaine Smoking prevention & control, Complement Factor I genetics, Renal Insufficiency diagnosis, Renal Insufficiency therapy, Thrombocytopenia diagnosis, Thrombocytopenia etiology, Thrombocytopenia therapy
- Abstract
Atypical haemolytic uraemic syndrome (aHUS) is a severe, life-threatening condition that requires early recognition and urgent treatment. In aHUS rare genetic variants in CFH, CFI, CD46, C3 and CFB predispose to complement over activation. This case describes a case of aHUS in which there was a strong temporal association between disease onset and the use of smoked cocaine. The patient was found to have a rare genetic variant in the CFI gene which may have been unmasked by first-time exposure to cocaine. The patient stabilized and improved with early administration of eculizumab, supporting the notion of an underlying immunological pathogenesis and the importance of early intervention., (© 2020 Asian Pacific Society of Nephrology.)
- Published
- 2020
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