1. Transfusion of plasma from a blood donor induced hepatitis E in Rhesus monkey.
- Author
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Xia NS, Zhang J, Zheng YJ, Ge SX, Ye XZ, and Ou SH
- Subjects
- Animals, Humans, Macaca mulatta, Transplantation, Heterologous, Viremia transmission, Blood Donors, Hepatitis E transmission, Transfusion Reaction
- Abstract
Background and Objectives: Hepatitis E virus (HEV) infection is normally transmitted via the faeco-oral route. The possibility that the infection might be transmissible by blood has been suggested. Direct evidence of blood-borne transmission of hepatitis E infection is, however, absent., Materials and Methods: In this report, 10 ml of plasma obtained from a healthy, but hepatitis E viraemic, blood donor was transfused to a Rhesus monkey., Results: Acute hepatitis E developed following transfusion of blood from the hepatitis E viraemic donor. This was confirmed by virological, immunological, biochemical and histopathological data., Conclusions: These results, combined with other epidemiological findings previously reported, indicate that transfusion-associated hepatitis E can occur. The risk of transfusion-associated HEV infection in endemic areas should be assessed and strategies developed to reduce it.
- Published
- 2004
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