1. CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study.
- Author
-
Lima SC, Gomes da Silva IIF, Nascimento DQ, de Moura RR, Mesquita MDS, Asano NMJ, Fernandes GV, Valente LM, Rushansky E, Mariano MHQA, Xavier RM, Chies JAB, Crovella S, and Sandrin-Garcia P
- Subjects
- Case-Control Studies, Cohort Studies, Genetic Predisposition to Disease, Genotype, Humans, Polymorphism, Single Nucleotide, Arthritis, Rheumatoid genetics, Lupus Erythematosus, Systemic genetics, Nuclear Proteins genetics, Trans-Activators genetics
- Abstract
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator of the HLA transcriptional complex; the single nucleotide variant (SNV) rs3087456 localized in the gene promoter region (-168 A/G) has been reported as able to modify its transcription level. In our study, we assessed CIITA rs3087456 SNV in 1,044 Brazilians from two Brazilian regions (Northeast and South) to verify the association with susceptibility and clinical manifestations of (SLE) and (RA) using TaqMan SNP Genotyping Assays System. We observed a protection for a recessive model (GG x AA+AG) for RA susceptibility and increased risk for erosion development in AG genotype patients. No significant association was observed for SLE susceptibility; however, we observed significant increased risk for Class IV and V nephritis development in G allele and GG genotype patients. In conclusion, we showed the contribution of CIITA rs3087456 to SLE or RA clinical features and RA susceptibility in the studied populations., (© 2021 John Wiley & Sons Ltd.)
- Published
- 2021
- Full Text
- View/download PDF