1. Novel chlorinated tropanes derived from the treatment of cocaine with sodium hypochlorite.
- Author
-
Casale JF, Moore JM, and Cooper DA
- Subjects
- Chlorine chemistry, Flame Ionization, Gas Chromatography-Mass Spectrometry, Isomerism, Mass Spectrometry, Molecular Structure, Oxidation-Reduction, Tropanes chemistry, Cocaine chemistry, Criminology methods, Sodium Hypochlorite chemistry, Tropanes chemical synthesis
- Abstract
Several novel chlorinated tropanes were produced when cocaine was treated with aqueous sodium hypochlorite. Two of these, 2'- and 3'-chlorobenzoyloxy-2-carbomethoxypseudotropine (that is, ortho- and meta-chlorococaine), were characterized by synthesis and gas chromatography/mass spectrometry. Four other new chlorinated tropanes (endo-6- and 7-chlorococaine, exo-6- or 7-chlorococaine and N-chlorobenzoylnorecgonine methyl ester) were also tentatively identified via their gas chromatography retention data and mass spectra. The results are of potential use in cocaine signature and comparative analysis.
- Published
- 1995