1. Effects of immunosuppressant FK-506 on tooth movement.
- Author
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Santos RL, de Farias ML, de Mendonça LM, Gonçalves RT, Martins MA, and de Souza MM
- Subjects
- Alveolar Process cytology, Animals, Apoptosis, Bone Density drug effects, Bone Resorption, Dental Stress Analysis, Leukocyte Count, Male, Osteoclasts drug effects, Random Allocation, Rats, Rats, Wistar, Bone Remodeling drug effects, Immunosuppressive Agents pharmacology, Tacrolimus pharmacology, Tooth Movement Techniques
- Abstract
Objective: To test the hypothesis that immunosuppressant tacrolimus treatment can interfere with bone turnover and rate of tooth movement., Material and Methods: One-hundred twenty Wistar male rats were divided into four groups: Group 1 (rats subjected to orthodontic movement plus treatment with saline solution vehicle), Group 2 (rats subjected to orthodontic movement plus treatment with FK506), Group 3 (rats treated with FK506 only), and Group 4 (rats treated with saline solution vehicle). The maxillary incisors were laterally moved with a reciprocal load of 35 cN. The dosage of FK506 was 2 mg/kg/day. Howship's lacunae, osteoclasts, and macrophages were counted., Results: Tooth movement was found to be greater in Group 1 than in Group 2 for all time periods (on days 3, 7, and 14), although a significant difference was observed only on days 7 and 14 (p < 0.05). The number of osteoclasts was smaller in Group 1 than in Group 2, whereas the number of Howship's lacunae was greater., Conclusion: FK506 has the capacity of promoting osteoclasts inhibition with probable osteoclastic apoptosis of alveolar bone following tooth movement.
- Published
- 2010
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