1. Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome.
- Author
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Gutiérrez A, Solano C, Ferrández A, Marugán I, Terol MJ, Benet I, Tormo M, Bea MD, and Rodríguez J
- Subjects
- Biopsy, Bone Marrow Cells metabolism, CD3 Complex biosynthesis, CD8 Antigens biosynthesis, Dose-Response Relationship, Drug, Female, Granulocyte-Macrophage Colony-Stimulating Factor blood, Humans, Interleukin-5 biosynthesis, Interleukin-5 metabolism, Lymphoma, Middle Aged, Phenotype, Th1 Cells immunology, Th2 Cells immunology, Histiocytosis, Non-Langerhans-Cell pathology, Hypereosinophilic Syndrome pathology, Lymphoma, T-Cell, Peripheral complications
- Abstract
Both hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome have been associated with hematologic neoplasms and are respectively related to an overproduction of the cytokines Thelper 1 (Th1) and Th2 by tumor cells or reactive cells. To our knowledge, this is the first time a case of a peripheral T-cell lymphoma consecutively associated with both paraneoplastic conditions has been reported. Importantly, in this case when the lymphoma exclusively involved the bone marrow, severe paraneoplastic systemic damage, a CD8+ suppressor/cytotoxic phenotype and a hypereosinophilia not related to high levels of interleukin (IL)-5 was found. Interestingly, progression of the lymphoma coincided with an increase in the serum levels of several Th2 cytokines and IL-2, a decrease in tumor necrosis factor and granulocyte-macrophage colony-stimulating factor levels and the onset of a hypereosinophilic syndrome.
- Published
- 2003
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