1. Immunoradiometric Assay of Total PSA, Free PSA and PSA Ratio Calculation in Prostatic Cancer (PCa) Diagnosis
- Author
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Paola Erba, L Ceriani, Luca Giovanella, S Garancini, and Patrizia Vio
- Subjects
medicine.medical_specialty ,Immunoradiometric assay ,Receiver operating characteristic ,business.industry ,Histological diagnosis ,Free psa ,Urology ,medicine ,Cancer ,urologic and male genital diseases ,medicine.disease ,business ,Total psa - Abstract
Total PSA assay is a well established procedure for biochemical evaluation and management of PCa which usefulness in its diagnosis is limited by its weak specificity with regard to BPH. Recently the assay of Free-PSA and the calculation of Free/Total-PSA Ratio has been suggested to improve the specificity of PSA in the range of concentrations between 2.5 and 20 ng/mL. We evaluated the diagnostic performance of PSA-Ratio among untreated patients with PSA levels ranging from 2.5 to 20 ng/mL and histological diagnosis of PCa or BPH. As the ROC curves analysis showed PSA-Ratio is the better parameter to discriminate between PCa and BPH: PSA-Ratio could be employed to enhance the diagnostic performance of PSA alone in PCa diagnosis.
- Published
- 1999
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