1. Predicting outcome in hematological stem cell transplantation.
- Author
-
Dickinson AM, Cavet J, Cullup H, Wang XN, Jarvis M, Sviland L, and Middleton PG
- Subjects
- Cytokines genetics, Graft vs Host Disease etiology, Humans, Polymorphism, Genetic, Transplantation, Homologous, Treatment Outcome, Hematopoietic Stem Cell Transplantation
- Abstract
This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-alpha, IFN-gamma, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell transplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.
- Published
- 2002